Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
1'-hydroxy-2'-oxopropyltetrahydropterin + NADP+
L-erythro-tetrahydrobiopterin + NADPH
-
-
-
?
1'-hydroxy-2'-oxopropyltetrahydropterin + NADPH
L-erythrotetrahydrobiopterin + NADP+
-
-
-
-
?
1'-oxo-2'-D-hydroxypropyl-tetrahydropterin + NADP+
D-sepiapterin + NADPH
1'-oxo-2'-D-hydroxypropyl-tetrahydropterin + NADPH
tetrahydrodictyopterin + NADP+
1'-oxo-2'-hydroxypropyl-tetrahydropterin + NADPH + H+
tetrahydrobiopterin + NADP+
-
-
-
?
1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADP+
L-sepiapterin + NADPH
1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADPH
L-erythro-tetrahydrobiopterin + NADP+
1,2-cyclohexadione + NADPH
?
-
-
-
-
?
1,2-naphthoquinone + NADPH
?
-
-
-
-
?
1,4-naphthoquinone + NADPH + H+
?
-
-
-
-
?
1-phenyl-1,2-propanedione + NADPH
?
-
-
-
-
?
2,3-butanediol + NADP+
?
-
-
-
-
?
2,3-dimethoxynaphthalene-1,4-dione + NADPH
?
-
-
-
-
?
2,4-pentanedione + NADPH
?
-
-
-
-
?
2-amino-6-(2-hydroxypropanoyl)pteridin-4(1H)-one + NADPH + H+
?
-
-
-
-
r
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
6-pyruvoyl tetrahydropterin + 2 NADPH + 2 H+
L-threo-(6R,1'S,2'S)-5,6,7,8-tetrahydrobiopterin + NADP+
6-pyruvoyl tetrahydropterin + 2 NADPH + 2 H+
tetrahydrobiopterin + NADP+
6-pyruvoyl tetrahydropterin + NADPH + H+
1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADP+
6-pyruvoyl-5,6,7,8-tetrahydropterin + NADPH
tetrahydrobiopterin + NADP+
6-pyruvoyltetrahydropterin + 2 NADPH + 2 H+
L-erythro-tetrahydrobiopterin + 2 NADP+
6-pyruvoyltetrahydropterin + 2 NADPH + 2 H+
L-threo-tetrahydrobiopterin + 2 NADP+
6-pyruvoyltetrahydropterin + NADPH
1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADP+
-
-
no synthesis of the D-isomer
-
?
9,10-phenanthrenequinone + NADP+
?
-
-
-
-
?
9,10-phenanthrenequinone + NADPH
?
-
-
-
-
?
acetohexamide + NADPH
?
-
-
-
-
?
acetophenone + NADPH
?
-
-
-
-
?
benzylacetone + NADPH
?
-
-
-
-
?
diacetyl + NADPH
acetoin + NADP+
-
NADPH-dependent dicarbonyl reductase activity
-
-
?
dihydrotepidopterin + NADP+
?
-
15% relative activity
-
-
?
isosepiapterin + NADPH
6-(1-hydroxypropyl)-dihydropterin + NADP+
-
-
-
?
isosepiapterin + NADPH
? + NADP+
-
-
-
-
r
L-erythro-dihydrobiopterin + NADP+
?
-
-
-
-
?
L-erythro-dihydroneopterin + NADP+
?
L-threo-dihydrobiopterin + NADP+
?
-
D-isomer 45% relative activity
-
-
r
L-threo-dihydroneopterin + NADP+
?
lactoyltetrahydropterin + NADPH
L-erythrotetrahydrobiopterin + NADP+
-
-
-
-
?
lactoyltetrahydropterin + NADPH + H+
L-erythro-tetrahydrobiopterin + NADP+
-
-
-
?
p-nitrobenzaldehyde + NADPH
p-nitrobenzyl alcohol + NADP+
p-quinone + NADPH
?
-
-
-
-
?
phenylpropanedione + NADPH
phenylpropan-2,3-diol + NADP+
-
NADPH-dependent dicarbonyl reductase activity
-
-
?
propiophenone + NADPH
?
-
-
-
-
?
pyruvoyltetrahydropterin + NADPH
L-erythrotetrahydrobiopterin + NADP+
-
-
-
-
?
sepiapterin + NADPH + H+
7,8-dihydrobiopterin + NADP+
sepiapterin + NADPH + H+
dihydrobiopterin + NADP+
-
best substrate
-
-
?
sepiapterin + NADPH + H+
L-erythro-7,8-dihydrobiopterin + NADP+
-
-
-
?
sepiapterin + NADPH + H+
tetrahydrobiopterin + NADP+
xanthopterin B2 + NADPH
6-(1',2'-dihydroxypropyl)-dihydrolumazine + NADP+
-
-
-
?
xanthopterin-B2 + NADPH
? + NADP+
-
-
-
-
r
additional information
?
-
1'-oxo-2'-D-hydroxypropyl-tetrahydropterin + NADP+
D-sepiapterin + NADPH
-
-
i.e. 1'-oxo-2'-D-hydroxypropyl-dihydropterin
-
?
1'-oxo-2'-D-hydroxypropyl-tetrahydropterin + NADP+
D-sepiapterin + NADPH
-
-
i.e. 1'-oxo-2'-D-hydroxypropyl-dihydropterin
-
?
1'-oxo-2'-D-hydroxypropyl-tetrahydropterin + NADPH
tetrahydrodictyopterin + NADP+
-
-
-
-
?
1'-oxo-2'-D-hydroxypropyl-tetrahydropterin + NADPH
tetrahydrodictyopterin + NADP+
-
preferred substrate
-
-
?
1'-oxo-2'-D-hydroxypropyl-tetrahydropterin + NADPH
tetrahydrodictyopterin + NADP+
-
-
-
-
?
1'-oxo-2'-D-hydroxypropyl-tetrahydropterin + NADPH
tetrahydrodictyopterin + NADP+
-
preferred substrate
-
-
?
1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADP+
L-sepiapterin + NADPH
-
-
i.e. 1'-oxo-2'-L-hydroxypropyl-dihydropterin
-
?
1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADP+
L-sepiapterin + NADPH
-
-
i.e. 1'-oxo-2'-L-hydroxypropyl-dihydropterin
-
?
1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADPH
L-erythro-tetrahydrobiopterin + NADP+
-
-
-
-
?
1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADPH
L-erythro-tetrahydrobiopterin + NADP+
-
-
-
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
-
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
-
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
-
-
r
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
-
-
r
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
-
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
-
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
-
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
-
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
-
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
-
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
-
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
-
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
in the reverse reaction, L-erythro and L-threo-dihydroneopterin are also oxidized, the corresponding L-isomers are inactive
-
r
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
equilibrium lies much in favor of dihydrobiopterin formation
-
r
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
reverse reaction, L-erythro and L-threo-dihydroneopterin are also oxidized, the corresponding D-isomers are inactive
-
r
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
-
-
r
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
-
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
-
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
-
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
-
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
terminal step in the biosynthetic pathway for tetrahydrobiopterin
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
terminal step in the biosynthetic pathway for tetrahydrobiopterin
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
terminal step in the biosynthetic pathway for tetrahydrobiopterin
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
-
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
-
-
r
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
terminal step in the biosynthetic pathway for tetrahydrobiopterin
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
-
-
r
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
-
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
-
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
-
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
-
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
-
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
-
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
-
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
-
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
-
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
-
-
r
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
in the reverse reaction, L-erythro and L-threo-dihydroneopterin are also oxidized, the corresponding L-isomers are inactive
-
r
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
equilibrium lies much in favor of dihydrobiopterin formation
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
equilibrium lies much in favor of dihydrobiopterin formation
-
r
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
terminal step in the biosynthetic pathway for tetrahydrobiopterin
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
terminal step in the biosynthetic pathway for tetrahydrobiopterin
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
terminal step in the biosynthetic pathway for tetrahydrobiopterin
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
terminal step in the biosynthetic pathway for tetrahydrobiopterin
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
reverse reaction, L-erythro and L-threo-dihydroneopterin are also oxidized, the corresponding D-isomers are inactive
-
r
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
catalyzes the complete reduction of pyrovoyltetrahydropterin to tetrahydrobiopterin
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
-
-
r
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
-
-
r
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
-
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
terminal step in the biosynthetic pathway for tetrahydrobiopterin
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
-
-
r
6-pyruvoyl tetrahydropterin + 2 NADPH + 2 H+
L-threo-(6R,1'S,2'S)-5,6,7,8-tetrahydrobiopterin + NADP+
-
-
-
-
?
6-pyruvoyl tetrahydropterin + 2 NADPH + 2 H+
L-threo-(6R,1'S,2'S)-5,6,7,8-tetrahydrobiopterin + NADP+
-
last step of the de novo tetrahydrobiopterin biosynthesis initiating from GTP
-
-
?
6-pyruvoyl tetrahydropterin + 2 NADPH + 2 H+
L-threo-(6R,1'S,2'S)-5,6,7,8-tetrahydrobiopterin + NADP+
-
last step of the tetrahydrobiopterin biosynthesis
-
-
?
6-pyruvoyl tetrahydropterin + 2 NADPH + 2 H+
L-threo-(6R,1'S,2'S)-5,6,7,8-tetrahydrobiopterin + NADP+
-
substrate binding mode for stereospecific production of L-threo-tetrahydrobiopterin, structure-function relationship
-
-
?
6-pyruvoyl tetrahydropterin + 2 NADPH + 2 H+
L-threo-(6R,1'S,2'S)-5,6,7,8-tetrahydrobiopterin + NADP+
-
two reductive steps oxidizing NADPH
-
-
?
6-pyruvoyl tetrahydropterin + 2 NADPH + 2 H+
tetrahydrobiopterin + NADP+
-
-
-
-
?
6-pyruvoyl tetrahydropterin + 2 NADPH + 2 H+
tetrahydrobiopterin + NADP+
-
final step in the synthesis of tetrahydrobiopterin, role in detoxification of exogenous carbonyl compounds suggested
-
-
?
6-pyruvoyl tetrahydropterin + NADPH + H+
1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADP+
-
-
-
-
?
6-pyruvoyl tetrahydropterin + NADPH + H+
1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADP+
-
1'-oxo-2'-D-hydroxypropyl-tetrahydropterin is formed by an aldose reductase-like enzyme activity, not by SR
-
-
?
6-pyruvoyl tetrahydropterin + NADPH + H+
1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADP+
-
-
-
-
?
6-pyruvoyl tetrahydropterin + NADPH + H+
1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADP+
-
-
-
-
?
6-pyruvoyl-5,6,7,8-tetrahydropterin + NADPH
tetrahydrobiopterin + NADP+
-
-
-
-
r
6-pyruvoyl-5,6,7,8-tetrahydropterin + NADPH
tetrahydrobiopterin + NADP+
-
-
-
-
r
6-pyruvoyl-5,6,7,8-tetrahydropterin + NADPH
tetrahydrobiopterin + NADP+
-
-
the cofactor for aromatic amino acid hydrolases in the biosynthesis of aromatc amino acids and dopamine
-
r
6-pyruvoyl-5,6,7,8-tetrahydropterin + NADPH
tetrahydrobiopterin + NADP+
-
-
-
-
r
6-pyruvoyltetrahydropterin + 2 NADPH + 2 H+
L-erythro-tetrahydrobiopterin + 2 NADP+
-
-
-
?
6-pyruvoyltetrahydropterin + 2 NADPH + 2 H+
L-erythro-tetrahydrobiopterin + 2 NADP+
-
-
-
?
6-pyruvoyltetrahydropterin + 2 NADPH + 2 H+
L-erythro-tetrahydrobiopterin + 2 NADP+
-
-
-
-
?
6-pyruvoyltetrahydropterin + 2 NADPH + 2 H+
L-threo-tetrahydrobiopterin + 2 NADP+
-
-
no formation of the L-erythro isomer
-
?
6-pyruvoyltetrahydropterin + 2 NADPH + 2 H+
L-threo-tetrahydrobiopterin + 2 NADP+
-
final step in the synthesis of tetrahydrobiopterin
no formation of the L-erythro isomer
-
?
6-pyruvoyltetrahydropterin + 2 NADPH + 2 H+
L-threo-tetrahydrobiopterin + 2 NADP+
-
no formation of the L-erythro isomer
-
?
6-pyruvoyltetrahydropterin + 2 NADPH + 2 H+
L-threo-tetrahydrobiopterin + 2 NADP+
final step in the synthesis of tetrahydrobiopterin
no formation of the L-erythro isomer
-
?
acetoin + NADPH
?
-
-
-
-
?
acetoin + NADPH
?
-
0.003 mM NADPH oxidised per 30 min
-
-
?
benzil + NADPH
?
-
-
-
-
?
benzil + NADPH
?
-
NADPH-dependent dicarbonyl reductase activity
-
-
?
diacetyl + NADPH
?
-
-
-
-
?
diacetyl + NADPH
?
-
-
-
-
?
diacetyl + NADPH
?
-
-
-
-
?
diacetyl + NADPH
?
-
-
-
-
?
L-erythro-dihydroneopterin + NADP+
?
-
D-isomer completely inactive
-
-
r
L-erythro-dihydroneopterin + NADP+
?
-
very slow activity, no activity with the D-isomer
-
-
r
L-threo-dihydroneopterin + NADP+
?
-
-
-
-
?
L-threo-dihydroneopterin + NADP+
?
-
D-isomer completely inactive
-
-
r
L-threo-dihydroneopterin + NADP+
?
-
very slow activity, no activity with the D-isomer
-
-
r
menadione + NADPH
?
-
-
-
-
?
menadione + NADPH
?
-
-
-
-
?
menadione + NADPH
?
-
-
-
-
?
menadione + NADPH
?
-
-
-
-
?
methylglyoxal + NADPH
?
-
-
-
-
?
methylglyoxal + NADPH
?
-
-
-
-
?
methylglyoxal + NADPH
?
-
-
-
-
?
p-nitrobenzaldehyde + NADPH
p-nitrobenzyl alcohol + NADP+
-
-
-
-
?
p-nitrobenzaldehyde + NADPH
p-nitrobenzyl alcohol + NADP+
-
-
-
-
?
phenylglyoxal + NADPH
?
-
-
-
-
?
phenylglyoxal + NADPH
?
-
-
-
-
?
phenylglyoxal + NADPH
?
-
-
-
-
?
phenylglyoxal + NADPH
?
-
-
-
-
?
sepiapterin + NADPH + H+
7,8-dihydrobiopterin + NADP+
-
-
-
-
?
sepiapterin + NADPH + H+
7,8-dihydrobiopterin + NADP+
-
-
-
?
sepiapterin + NADPH + H+
7,8-dihydrobiopterin + NADP+
-
-
-
-
?
sepiapterin + NADPH + H+
7,8-dihydrobiopterin + NADP+
-
-
-
?
sepiapterin + NADPH + H+
7,8-dihydrobiopterin + NADP+
-
-
-
-
r
sepiapterin + NADPH + H+
7,8-dihydrobiopterin + NADP+
-
-
-
-
r
sepiapterin + NADPH + H+
7,8-dihydrobiopterin + NADP+
-
-
-
-
?
sepiapterin + NADPH + H+
7,8-dihydrobiopterin + NADP+
-
-
-
-
r
sepiapterin + NADPH + H+
7,8-dihydrobiopterin + NADP+
-
-
-
?
sepiapterin + NADPH + H+
7,8-dihydrobiopterin + NADP+
-
-
-
-
?
sepiapterin + NADPH + H+
7,8-dihydrobiopterin + NADP+
-
cellular uptake of sepiapterin across the cell membrane results in an efficient accumulation of tetrahydrobiopterin, sepiapterin relocates across the plasma membrane via two distinct paths, the slower path connects to the cytosolic compartment, overview
-
-
r
sepiapterin + NADPH + H+
7,8-dihydrobiopterin + NADP+
no stereochemic specification in the publication
-
-
?
sepiapterin + NADPH + H+
7,8-dihydrobiopterin + NADP+
-
-
-
-
?
sepiapterin + NADPH + H+
7,8-dihydrobiopterin + NADP+
-
-
-
-
r
sepiapterin + NADPH + H+
7,8-dihydrobiopterin + NADP+
-
-
-
?
sepiapterin + NADPH + H+
7,8-dihydrobiopterin + NADP+
-
-
-
-
?
sepiapterin + NADPH + H+
7,8-dihydrobiopterin + NADP+
-
-
-
-
r
sepiapterin + NADPH + H+
7,8-dihydrobiopterin + NADP+
-
-
detailed product determination and analysis using fluorescent substrates, 7,8-dihydrobiopterin can be oxidized nonenzymatically to biopterin
-
?
sepiapterin + NADPH + H+
7,8-dihydrobiopterin + NADP+
-
i.e. 2-amino-4-hydroxy-6-lactyl-7,8-dihydropteridine, biosynthesis pathway, overview
i.e. 2-amino-4-hydroxy-6-(1',2'-dihydroxypropyl-)7,8-dihydropteridine, which is a substrate for biosynthesis of tetrahydrobiopterin, i.e. 6R-L-erythro-1',2'-dihydroxy-propyl-2-amino-4-hydroxy-5,6,7,8-tetrahydropteridine, an important component for controling the concentration of catecholamines or indoleamines in the brain and other nerve tissues
-
?
sepiapterin + NADPH + H+
7,8-dihydrobiopterin + NADP+
-
sepiapterin reductase activity
-
-
?
sepiapterin + NADPH + H+
7,8-dihydrobiopterin + NADP+
no stereochemic specification in the publication
-
-
?
sepiapterin + NADPH + H+
7,8-dihydrobiopterin + NADP+
-
-
-
-
?
sepiapterin + NADPH + H+
tetrahydrobiopterin + NADP+
-
no stereochemic specification in the publication
-
?
sepiapterin + NADPH + H+
tetrahydrobiopterin + NADP+
-
-
no stereochemic specification in the publication
-
?
sepiapterin + NADPH + H+
tetrahydrobiopterin + NADP+
-
no stereochemic specification of the substrate in the publication
-
?
sepiapterin + NADPH + H+
tetrahydrobiopterin + NADP+
-
no stereochemic specification in the publication
-
?
additional information
?
-
-
not: methylglyoxal, menadione
-
-
?
additional information
?
-
-
product determination
-
-
?
additional information
?
-
-
D-threo-tetrahydrobiopterin is synthesized via 1'-oxo-2'-D-hydroxypropyl-tetrahydropterin in Dictyostelium discoideum strain Ax2
-
-
?
additional information
?
-
-
quantitative in vivo assay and product determination
-
-
?
additional information
?
-
-
tetrahydropteridines in Dictyostelium are associated with mitochondrial function, probably via direct protection against oxidative stress, tetrahydropteridine deficiency impairs mitochondrial function in Dictyostelium discoideum Ax2
-
-
?
additional information
?
-
-
the enzyme catalyzes the final step in the tetrahydrobiopterin biosynthesis
-
-
?
additional information
?
-
-
product determination
-
-
?
additional information
?
-
-
quantitative in vivo assay and product determination
-
-
?
additional information
?
-
-
D-threo-tetrahydrobiopterin is synthesized via 1'-oxo-2'-D-hydroxypropyl-tetrahydropterin in Dictyostelium discoideum strain Ax2
-
-
?
additional information
?
-
-
not: 6-acetyl-7-methyldihydropterin
-
-
?
additional information
?
-
-
no activity with 6-acetyl-7-methyl-7,8-dihydropterin
-
-
?
additional information
?
-
-
final step in the synthesis of tetrahydrobiopterin
-
-
?
additional information
?
-
-
the enzyme is involved in the tetrahydrobiopterin biosynthesis
-
-
?
additional information
?
-
-
sepiapterin or dihydrobiopterin are the precursors of the tetrahydrobiopterin-salvage pathway, enzyme activity and pathway regulation in vivo, overview
-
-
?
additional information
?
-
-
the enzyme catalyzes the final step in the tetrahydrobiopterin biosynthesis
-
-
?
additional information
?
-
-
the enzyme catalyzes the final step in the tetrahydrobiopterin biosynthesis, sepiapterin reductase expression is increased in Parkinsons disease brain tissue
-
-
?
additional information
?
-
native ornithine decarboxylase, EC 4.1.1.17, and sepiapterin reductase physically interact, in silico protein-protein docking simulations
-
-
?
additional information
?
-
-
native ornithine decarboxylase, EC 4.1.1.17, and sepiapterin reductase physically interact, in silico protein-protein docking simulations
-
-
?
additional information
?
-
physical interaction between key polyamines biosynthesis enzyme ornithine decarboxylase (ODC) and sepiapterin reductase (SPR)
-
-
?
additional information
?
-
-
physical interaction between key polyamines biosynthesis enzyme ornithine decarboxylase (ODC) and sepiapterin reductase (SPR)
-
-
?
additional information
?
-
the enzyme's one-electron reduction of redox cycling chemicals, such as menadione, generates radical cations. The rapid reaction of these cations with molecular oxygen regenerates the redox active chemical, and in the process superoxide anion is formed. Sepiapterin reduction is catalyzed by NADPH, whereas chemical redox cycling is catalyzed by NADPH and/or NADH, overview
-
-
?
additional information
?
-
-
the enzyme's one-electron reduction of redox cycling chemicals, such as menadione, generates radical cations. The rapid reaction of these cations with molecular oxygen regenerates the redox active chemical, and in the process superoxide anion is formed. Sepiapterin reduction is catalyzed by NADPH, whereas chemical redox cycling is catalyzed by NADPH and/or NADH, overview
-
-
?
additional information
?
-
-
final step in the synthesis of tetrahydrobiopterin
-
-
?
additional information
?
-
-
important in the metabolism of tetrahydrobiopterin and sepiapterin
-
-
?
additional information
?
-
-
enzyme is quite similar to general aldo-keto reductases, especially to carbonyl reductase
-
-
?
additional information
?
-
-
some monoketotestosterones show slight activity
-
-
?
additional information
?
-
-
not: 6-acetyl-7-methyldihydropterin
-
-
?
additional information
?
-
-
enzyme also catalyzes the isomerization of 6-1'-oxo-2'-hydroxypropyl tetrahydropterin (6-lactoyltetrahydropterin) to 6-1'-hydroxy-2'-oxopropyltetrahydropterin
-
-
?
additional information
?
-
-
final step in the synthesis of tetrahydrobiopterin
-
-
?
additional information
?
-
-
the enzyme might be involved in regulation of biosynthesis of catecholamines, indoleamines, and tetrahydrobiopterins
-
-
?
additional information
?
-
-
descending substrate preference: sepiapterin, lactoyltetrahydropterin, pyruvoyltetrahydropterin, 1'-hydroxy-2'-oxopropyltetrahydropterin
-
-
?
additional information
?
-
-
substrate specificity, the enzyme also exhibits non-specific NADPH-dependent dicarbonyl reductase activity, overview
-
-
?
additional information
?
-
the enzyme's one-electron reduction of redox cycling chemicals, such as menadione, generates radical cations. The rapid reaction of these cations with molecular oxygen regenerates the redox active chemical, and in the process superoxide anion is formed. Sepiapterin reduction is catalyzed by NADPH, whereas chemical redox cycling is catalyzed by NADPH and/or NADH, overview
-
-
?
additional information
?
-
-
the enzyme might be involved in regulation of biosynthesis of catecholamines, indoleamines, and tetrahydrobiopterins
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
1'-oxo-2'-D-hydroxypropyl-tetrahydropterin + NADP+
D-sepiapterin + NADPH
1'-oxo-2'-D-hydroxypropyl-tetrahydropterin + NADPH
tetrahydrodictyopterin + NADP+
1'-oxo-2'-hydroxypropyl-tetrahydropterin + NADPH + H+
tetrahydrobiopterin + NADP+
-
-
-
?
1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADP+
L-sepiapterin + NADPH
1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADPH
L-erythro-tetrahydrobiopterin + NADP+
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
6-pyruvoyl tetrahydropterin + 2 NADPH + 2 H+
L-threo-(6R,1'S,2'S)-5,6,7,8-tetrahydrobiopterin + NADP+
6-pyruvoyl tetrahydropterin + 2 NADPH + 2 H+
tetrahydrobiopterin + NADP+
-
final step in the synthesis of tetrahydrobiopterin, role in detoxification of exogenous carbonyl compounds suggested
-
-
?
6-pyruvoyl tetrahydropterin + NADPH + H+
1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADP+
-
-
-
-
?
6-pyruvoyl-5,6,7,8-tetrahydropterin + NADPH
tetrahydrobiopterin + NADP+
6-pyruvoyltetrahydropterin + 2 NADPH + 2 H+
L-threo-tetrahydrobiopterin + 2 NADP+
6-pyruvoyltetrahydropterin + NADPH
1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADP+
-
-
no synthesis of the D-isomer
-
?
sepiapterin + NADPH + H+
7,8-dihydrobiopterin + NADP+
sepiapterin + NADPH + H+
L-erythro-7,8-dihydrobiopterin + NADP+
-
-
-
?
sepiapterin + NADPH + H+
tetrahydrobiopterin + NADP+
additional information
?
-
1'-oxo-2'-D-hydroxypropyl-tetrahydropterin + NADP+
D-sepiapterin + NADPH
-
-
-
-
?
1'-oxo-2'-D-hydroxypropyl-tetrahydropterin + NADP+
D-sepiapterin + NADPH
-
-
-
-
?
1'-oxo-2'-D-hydroxypropyl-tetrahydropterin + NADPH
tetrahydrodictyopterin + NADP+
-
-
-
-
?
1'-oxo-2'-D-hydroxypropyl-tetrahydropterin + NADPH
tetrahydrodictyopterin + NADP+
-
-
-
-
?
1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADP+
L-sepiapterin + NADPH
-
-
-
-
?
1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADP+
L-sepiapterin + NADPH
-
-
-
-
?
1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADPH
L-erythro-tetrahydrobiopterin + NADP+
-
-
-
-
?
1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADPH
L-erythro-tetrahydrobiopterin + NADP+
-
-
-
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
-
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
-
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
-
-
r
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
-
-
r
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
-
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
-
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
-
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
-
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
-
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
-
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
-
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
-
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
equilibrium lies much in favor of dihydrobiopterin formation
-
r
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
reverse reaction, L-erythro and L-threo-dihydroneopterin are also oxidized, the corresponding D-isomers are inactive
-
r
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
-
-
r
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
-
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
terminal step in the biosynthetic pathway for tetrahydrobiopterin
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
terminal step in the biosynthetic pathway for tetrahydrobiopterin
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
terminal step in the biosynthetic pathway for tetrahydrobiopterin
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
-
-
r
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
terminal step in the biosynthetic pathway for tetrahydrobiopterin
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
-
-
r
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
-
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
-
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
-
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
-
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
-
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
-
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
-
-
r
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
equilibrium lies much in favor of dihydrobiopterin formation
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
equilibrium lies much in favor of dihydrobiopterin formation
-
r
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
terminal step in the biosynthetic pathway for tetrahydrobiopterin
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
terminal step in the biosynthetic pathway for tetrahydrobiopterin
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
terminal step in the biosynthetic pathway for tetrahydrobiopterin
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
terminal step in the biosynthetic pathway for tetrahydrobiopterin
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
reverse reaction, L-erythro and L-threo-dihydroneopterin are also oxidized, the corresponding D-isomers are inactive
-
r
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
catalyzes the complete reduction of pyrovoyltetrahydropterin to tetrahydrobiopterin
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
-
-
r
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
-
-
r
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
terminal step in the biosynthetic pathway for tetrahydrobiopterin
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
-
-
r
6-pyruvoyl tetrahydropterin + 2 NADPH + 2 H+
L-threo-(6R,1'S,2'S)-5,6,7,8-tetrahydrobiopterin + NADP+
-
last step of the de novo tetrahydrobiopterin biosynthesis initiating from GTP
-
-
?
6-pyruvoyl tetrahydropterin + 2 NADPH + 2 H+
L-threo-(6R,1'S,2'S)-5,6,7,8-tetrahydrobiopterin + NADP+
-
last step of the tetrahydrobiopterin biosynthesis
-
-
?
6-pyruvoyl-5,6,7,8-tetrahydropterin + NADPH
tetrahydrobiopterin + NADP+
-
-
-
-
r
6-pyruvoyl-5,6,7,8-tetrahydropterin + NADPH
tetrahydrobiopterin + NADP+
-
-
-
-
r
6-pyruvoyl-5,6,7,8-tetrahydropterin + NADPH
tetrahydrobiopterin + NADP+
-
-
the cofactor for aromatic amino acid hydrolases in the biosynthesis of aromatc amino acids and dopamine
-
r
6-pyruvoyl-5,6,7,8-tetrahydropterin + NADPH
tetrahydrobiopterin + NADP+
-
-
-
-
r
6-pyruvoyltetrahydropterin + 2 NADPH + 2 H+
L-threo-tetrahydrobiopterin + 2 NADP+
-
final step in the synthesis of tetrahydrobiopterin
no formation of the L-erythro isomer
-
?
6-pyruvoyltetrahydropterin + 2 NADPH + 2 H+
L-threo-tetrahydrobiopterin + 2 NADP+
final step in the synthesis of tetrahydrobiopterin
no formation of the L-erythro isomer
-
?
sepiapterin + NADPH + H+
7,8-dihydrobiopterin + NADP+
-
-
-
-
r
sepiapterin + NADPH + H+
7,8-dihydrobiopterin + NADP+
-
-
-
-
r
sepiapterin + NADPH + H+
7,8-dihydrobiopterin + NADP+
-
-
-
-
r
sepiapterin + NADPH + H+
7,8-dihydrobiopterin + NADP+
-
-
-
?
sepiapterin + NADPH + H+
7,8-dihydrobiopterin + NADP+
-
-
-
-
?
sepiapterin + NADPH + H+
7,8-dihydrobiopterin + NADP+
-
cellular uptake of sepiapterin across the cell membrane results in an efficient accumulation of tetrahydrobiopterin, sepiapterin relocates across the plasma membrane via two distinct paths, the slower path connects to the cytosolic compartment, overview
-
-
r
sepiapterin + NADPH + H+
7,8-dihydrobiopterin + NADP+
no stereochemic specification in the publication
-
-
?
sepiapterin + NADPH + H+
7,8-dihydrobiopterin + NADP+
-
-
-
-
r
sepiapterin + NADPH + H+
7,8-dihydrobiopterin + NADP+
-
-
-
?
sepiapterin + NADPH + H+
7,8-dihydrobiopterin + NADP+
-
-
-
-
?
sepiapterin + NADPH + H+
7,8-dihydrobiopterin + NADP+
-
i.e. 2-amino-4-hydroxy-6-lactyl-7,8-dihydropteridine, biosynthesis pathway, overview
i.e. 2-amino-4-hydroxy-6-(1',2'-dihydroxypropyl-)7,8-dihydropteridine, which is a substrate for biosynthesis of tetrahydrobiopterin, i.e. 6R-L-erythro-1',2'-dihydroxy-propyl-2-amino-4-hydroxy-5,6,7,8-tetrahydropteridine, an important component for controling the concentration of catecholamines or indoleamines in the brain and other nerve tissues
-
?
sepiapterin + NADPH + H+
7,8-dihydrobiopterin + NADP+
no stereochemic specification in the publication
-
-
?
sepiapterin + NADPH + H+
7,8-dihydrobiopterin + NADP+
-
-
-
-
?
sepiapterin + NADPH + H+
tetrahydrobiopterin + NADP+
-
no stereochemic specification in the publication
-
?
sepiapterin + NADPH + H+
tetrahydrobiopterin + NADP+
-
-
no stereochemic specification in the publication
-
?
additional information
?
-
-
D-threo-tetrahydrobiopterin is synthesized via 1'-oxo-2'-D-hydroxypropyl-tetrahydropterin in Dictyostelium discoideum strain Ax2
-
-
?
additional information
?
-
-
quantitative in vivo assay and product determination
-
-
?
additional information
?
-
-
tetrahydropteridines in Dictyostelium are associated with mitochondrial function, probably via direct protection against oxidative stress, tetrahydropteridine deficiency impairs mitochondrial function in Dictyostelium discoideum Ax2
-
-
?
additional information
?
-
-
quantitative in vivo assay and product determination
-
-
?
additional information
?
-
-
D-threo-tetrahydrobiopterin is synthesized via 1'-oxo-2'-D-hydroxypropyl-tetrahydropterin in Dictyostelium discoideum strain Ax2
-
-
?
additional information
?
-
-
final step in the synthesis of tetrahydrobiopterin
-
-
?
additional information
?
-
-
the enzyme is involved in the tetrahydrobiopterin biosynthesis
-
-
?
additional information
?
-
-
sepiapterin or dihydrobiopterin are the precursors of the tetrahydrobiopterin-salvage pathway, enzyme activity and pathway regulation in vivo, overview
-
-
?
additional information
?
-
-
the enzyme catalyzes the final step in the tetrahydrobiopterin biosynthesis
-
-
?
additional information
?
-
-
the enzyme catalyzes the final step in the tetrahydrobiopterin biosynthesis, sepiapterin reductase expression is increased in Parkinsons disease brain tissue
-
-
?
additional information
?
-
native ornithine decarboxylase, EC 4.1.1.17, and sepiapterin reductase physically interact, in silico protein-protein docking simulations
-
-
?
additional information
?
-
-
native ornithine decarboxylase, EC 4.1.1.17, and sepiapterin reductase physically interact, in silico protein-protein docking simulations
-
-
?
additional information
?
-
physical interaction between key polyamines biosynthesis enzyme ornithine decarboxylase (ODC) and sepiapterin reductase (SPR)
-
-
?
additional information
?
-
-
physical interaction between key polyamines biosynthesis enzyme ornithine decarboxylase (ODC) and sepiapterin reductase (SPR)
-
-
?
additional information
?
-
-
final step in the synthesis of tetrahydrobiopterin
-
-
?
additional information
?
-
-
important in the metabolism of tetrahydrobiopterin and sepiapterin
-
-
?
additional information
?
-
-
final step in the synthesis of tetrahydrobiopterin
-
-
?
additional information
?
-
-
the enzyme might be involved in regulation of biosynthesis of catecholamines, indoleamines, and tetrahydrobiopterins
-
-
?
additional information
?
-
-
the enzyme might be involved in regulation of biosynthesis of catecholamines, indoleamines, and tetrahydrobiopterins
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
(1s,4s)-4-[(2E)-2-[(4-fluorobenzoyl)imino]-6-[(piperidin-1-yl)methyl]-2,3-dihydro-1H-benzimidazol-1-yl]cyclohexane-1-carboxylic acid
-
(2,4-dichloro-6-hydroxyphenyl)(1,3-dihydro-2H-isoindol-2-yl)methanone
-
(2,4-dichloro-6-hydroxyphenyl)(2,3-dihydro-1H-indol-1-yl)methanone
-
(2,4-dichloro-6-hydroxyphenyl)(2-methyl-2,3-dihydro-1H-indol-1-yl)methanone
-
(2,4-dichloro-6-hydroxyphenyl)(2-methyl-2,6-diazaspiro[3.4]octan-6-yl)methanone
-
(2,4-dichloro-6-hydroxyphenyl)(2-oxa-6-azaspiro[3.4]octan-6-yl)methanone
-
(2,4-dichloro-6-hydroxyphenyl)(3,3-dimethylpyrrolidin-1-yl)methanone
-
(2,4-dichloro-6-hydroxyphenyl)(3,4-dihydroisoquinolin-2(1H)-yl)methanone
-
(2,4-dichloro-6-hydroxyphenyl)(3,4-dihydroquinolin-1(2H)-yl)methanone
-
(2,4-dichloro-6-hydroxyphenyl)(3-fluoro-3-methylpyrrolidin-1-yl)methanone
-
(2,4-dichloro-6-hydroxyphenyl)(3-phenylpyrrolidin-1-yl)methanone
-
(2,4-dichloro-6-hydroxyphenyl)(4-phenylpiperidin-1-yl)methanone
-
(2,4-dichloro-6-hydroxyphenyl)(pyrrolidin-1-yl)methanone
-
(2,4-dichloro-6-hydroxyphenyl)[3-(1-methyl-1H-pyrazol-4-yl)pyrrolidin-1-yl]methanone
-
(2,4-dichloro-6-hydroxyphenyl)[3-(2-phenylethyl)pyrrolidin-1-yl]methanone
-
(2,4-dichloro-6-hydroxyphenyl)[3-(pyridin-2-yl)pyrrolidin-1-yl]methanone
-
(2,4-dichloro-6-hydroxyphenyl)[3-(pyridin-3-yl)pyrrolidin-1-yl]methanone
-
(2,4-dichloro-6-hydroxyphenyl)[3-(pyridin-4-yl)pyrrolidin-1-yl]methanone
-
(2,4-dichloro-6-hydroxyphenyl)[3-(trifluoromethyl)pyrrolidin-1-yl]methanone
-
(2,4-dichloro-6-hydroxyphenyl)[3-[(pyridin-3-yl)methyl]pyrrolidin-1-yl]methanone
-
(2,4-dichloro-6-hydroxyphenyl)[3-[(pyridin-3-yl)oxy]pyrrolidin-1-yl]methanone
-
(2,4-dichloro-6-hydroxyphenyl)[3-[(pyridin-4-yl)methyl]pyrrolidin-1-yl]methanone
-
(2-azaspiro[3.4]octan-2-yl)(2,4-dichloro-6-hydroxyphenyl)methanone
-
(2-azaspiro[4.4]nonan-2-yl)(2,4-dichloro-6-hydroxyphenyl)methanone
-
(2-azaspiro[4.5]decan-2-yl)(2,4-dichloro-6-hydroxyphenyl)methanone
-
(2-hydroxy-6-methylpyridin-3-yl)(2-hydroxyphenyl)methanone
-
(2-hydroxyphenyl)[3-methyl-1-(pyridin-2-yl)-1H-pyrazolo[3,4-b]pyridin-5-yl]methanone
-
(3-anilinopyrrolidin-1-yl)(2,4-dichloro-6-hydroxyphenyl)methanone
-
(3-benzylpyrrolidin-1-yl)(2,4-dichloro-6-hydroxyphenyl)methanone
-
(4-benzylpiperidin-1-yl)(2,4-dichloro-6-hydroxyphenyl)methanone
-
(4S)-4-(8-hydroxyquinolin-2-yl)-1-methyl-3-(pyridin-3-yl)-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-b]pyridin-6-one
-
(5-azaspiro[2.4]heptan-5-yl)(2,4-dichloro-6-hydroxyphenyl)methanone
-
(6-aza-spiro[3.4]oct-6-yl)-(2,4-difluoro-6-hydroxyphenyl)methanone
-
(6-azaspiro[3.4]octan-6-yl)(2,3-dichloro-6-hydroxyphenyl)methanone
-
(6-azaspiro[3.4]octan-6-yl)(2,4-dichloro-3-fluoro-6-hydroxyphenyl)methanone
-
(6-azaspiro[3.4]octan-6-yl)(2,4-dichloro-6-hydroxyphenyl)methanone
-
(6-azaspiro[3.4]octan-6-yl)(2,4-dichloro-6-methoxyphenyl)methanone
-
(6-azaspiro[3.4]octan-6-yl)(2-chloro-4-fluoro-6-hydroxyphenyl)methanone
-
(6-azaspiro[3.4]octan-6-yl)(2-chloro-6-hydroxy-4-methoxyphenyl)methanone
-
(6-azaspiro[3.4]octan-6-yl)(2-chloro-6-hydroxy-4-methylphenyl)methanone
-
(6-azaspiro[3.4]octan-6-yl)(2-chloro-6-hydroxyphenyl)methanone
-
(6-azaspiro[3.4]octan-6-yl)(2-fluoro-6-hydroxy-4-methylphenyl)methanone
-
(6-azaspiro[3.4]octan-6-yl)(2-fluoro-6-hydroxyphenyl)methanone
-
(6-azaspiro[3.4]octan-6-yl)(2-hydroxypyridin-3-yl)methanone
-
(6-azaspiro[3.4]octan-6-yl)(3,4-dichloro-2-hydroxyphenyl)methanone
-
(6-azaspiro[3.4]octan-6-yl)(3,6-dichloro-2-hydroxyphenyl)methanone
-
(6-azaspiro[3.4]octan-6-yl)(3-chloro-5-hydroxypyridin-4-yl)methanone
-
(6-azaspiro[3.4]octan-6-yl)(3-hydroxypyridin-2-yl)methanone
-
(6-azaspiro[3.4]octan-6-yl)(3-hydroxypyridin-4-yl)methanone
-
(6-azaspiro[3.4]octan-6-yl)(4,5-dichloro-2-hydroxyphenyl)methanone
-
(6-azaspiro[3.4]octan-6-yl)(4-chloro-2-fluoro-6-hydroxyphenyl)methanone
-
(6-azaspiro[3.4]octan-6-yl)(4-chloro-2-hydroxy-6-methylphenyl)methanone
-
(6-azaspiro[3.4]octan-6-yl)(4-chloro-2-hydroxyphenyl)methanone
-
(6-azaspiro[3.4]octan-6-yl)(4-fluoro-2-hydroxyphenyl)methanone
-
(6-azaspiro[3.4]octan-6-yl)(4-hydroxypyridin-3-yl)methanone
-
(6-azaspiro[3.4]octan-6-yl)(5-chloro-3-hydroxypyridin-2-yl)methanone
-
(6-azaspiro[3.4]octan-6-yl)(5-fluoro-3-hydroxypyridin-2-yl)methanone
-
(6-azaspiro[3.4]octan-6-yl)(5-hydroxypyrimidin-4-yl)methanone
-
(6-azaspiro[3.4]octan-6-yl)[2-chloro-4-(dimethylamino)-6-hydroxyphenyl]methanone
-
(6-azaspiro[3.4]octan-6-yl)[2-chloro-6-hydroxy-4-(trifluoromethyl)phenyl]methanone
-
(6-azaspiro[3.5]nonan-6-yl)(2,4-dichloro-6-hydroxyphenyl)methanone
-
1-norepinephrine
-
3 mM: 30% inhibition
2,7,10-trimethyl-9-(4-methyl-2,6-dioxocyclohexane-1-carbonyl)-4,5-dihydro-6lambda6-[1]benzothiepino[5,4-c]pyrazole-6,6(2H)-dione
-
2-(6-azaspiro[3.4]octane-6-sulfonyl)-3,5-dichlorophenol
-
2-(6-azaspiro[3.4]octane-6-sulfonyl)-3,5-difluorophenol
-
2-(6-azaspiro[3.4]octane-6-sulfonyl)-3-fluorophenol
-
2-(6-azaspiro[3.4]octane-6-sulfonyl)-5-fluorophenol
-
3,3'-[(2,4-dichlorophenyl)methylene]di(1H-indole-6-carboxylic acid)
-
3-chloro-1-[2-methoxy-4-(trifluoromethyl)phenyl]-N-(1,3-thiazol-2-yl)isoquinoline-6-sulfonamide
-
3-hydroxy-4,4-dimethyl-1-oxo-N7-(2-phenylethyl)-1,4-dihydronaphthalene-2,7-dicarboxamide
-
3-[1-(3-propyl-1H-pyrazole-5-carbonyl)piperidin-4-yl]-3,4-dihydro-1lambda6,2,4-benzothiadiazine-1,1(2H)-dione
-
4-(4-[4-[4-(trifluoromethoxy)phenyl]-4H-1,2,4-triazol-3-yl]piperazin-1-yl)-6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidine
-
4-(6-azaspiro[3.4]octane-6-carbonyl)-3-chloro-5-hydroxybenzamide
-
4-(6-azaspiro[3.4]octane-6-carbonyl)-3-chloro-5-hydroxybenzonitrile
-
4-fluoro-N-[(2E)-1-[4-[(propan-2-yl)carbamoyl]cyclohexyl]-6-[(1H-1,2,4-triazol-1-yl)methyl]-1,3-dihydro-2H-benzimidazol-2-ylidene]benzamide
-
4-[(1,3-thiazol-2-yl)sulfamoyl]-N-[3-(trifluoromethyl)phenyl]piperidine-1-carboxamide
-
4-[2-(pyridin-4-yl)ethyl]-N-(1,3-thiazol-2-yl)-3,4-dihydro-2H-1,4-benzoxazine-7-sulfonamide
-
6,7-dimethyldihydropterin
-
0.05 mM: 70% inhibition
6,7-dimethyllumazine
-
slight
6,7-dimethylpterin
-
0.05 mM: 46% inhibition; 46% inhibition of the reductive reaction at 0.05 mM
6,7-dimethylpterin-H2
-
70% inhibition of the reductive reaction at 0.05 mM
6-Hydroxymethylpterin
-
0.05 mM: 23% inhibition; 23% inhibition of the reductive reaction at 0.05 mM
6-methyldihydropterin
-
0.05 mM: 59% inhibition
6-methylpterin
-
10% inhibition of the reductive reaction at 0.05 mM; slight
6-Methylpterin-H2
-
59% inhibition of the reductive reaction at 0.05 mM
7-(3,4-dihydroxyphenyl)-5-hydroxy-10-(2-hydroxyethyl)-2,2-dimethyl-2H,6H-benzo[1,2-b:5,4-b']dipyran-6-one
-
7-Methylpterin
-
0.05 mM: 18% inhibition; 18% inhibition of the reductive reaction at 0.05 mM
9,10-phenanthrenequinone
-
-
alpha-difluoromethylornithine
DFMO, IC50 value of 4.07 mM for SK-N-Be(2)c and 5.79 mM for LAN-5 cells
alpha-difluoromethylornitine
the combination of sulfasalazine with alpha-difluoromethylornitine produces synergistic antiproliferative effects on neuroblastoma cells in vitro
alpha-ketoglutarate
-
slight, IC50 5 mM
benzoic acid
-
0.03 mM: 40% inhibition; 40% inhibition of the reductive reaction at 0.03 mM
biopterin
-
0.05 mM: 24% inhibition; 24% inhibition of the reductive reaction at 0.05 mM
biopterin-H2
-
31% inhibition of the reductive reaction at 0.05 mM
Cibacron Blue 3G-A
-
IC50 0.01 mM
D,L-Lactic acid
-
0.03 mM, 20% inhibition
D-erythro-neopterin
-
14% inhibition of the reductive reaction at 0.05 mM
D-erythro-neopterin-H2
-
7% inhibition of the reductive reaction at 0.05 mM
dihydroxanthopterin
-
slight
DL-lactic acid
-
20% inhibition of the reductive reaction at 0.03 mM
dopamine
-
slight; slight inhibition
ethyl 6'-chloro-2'-hydroxy-4-(2-methoxy-2-oxoethylidene)-4'-oxo-4'H-spiro[cyclohexane-1,1'-naphthalene]-3'-carboxylate
-
ethyl 6-anilino-5-hydroxy-1,2-dimethyl-1H-indole-3-carboxylate
-
ethyl N-[(6-bromo-5-methoxy-1-methyl-3-propanoyl-1H-indol-2-yl)methyl]glycinate
-
Fe3+
-
1 mM inhibits entirely
iodoacetate
-
72% inhibition of the reductive reaction at 0.1 mM
Isoxanthopterin
-
0.05 mM: very slight
KCN
-
25% inhibition of the reductive reaction at 2.5 mM; slight
L-erythro-dihydroneopterin
-
0.05 mM: 29% inhibition, D-isomer: slight inhibition
L-Erythro-neopterin
-
0.05 mM: 21% inhibition, D-isomer: slight inhibition; 21% inhibition of the reductive reaction at 0.05 mM
L-Erythro-neopterin-H2
-
29% inhibition of the reductive reaction at 0.05 mM
Leucopterin
-
0.05 mM: 21% inhibition; 21% inhibition of the reductive reaction at 0.05 mM
N-(5-fluoropyridin-2-yl)-1-[2-hydroperoxy-4-(trifluoromethyl)phenyl]isoquinoline-6-sulfonamide
-
N-(pyridin-2-yl)-2,3-dihydro-1,4-benzodioxine-6-sulfonamide
-
N-acetyl-L-noradrenaline
-
weak inhibitor, N-acetyl-L-adrenaline does not bind enzyme
N-acetyl-p-tyramine
-
weak, N-acetyl-m-tyramine shows strong inhibition
N-acetyl-serotonin
-
complete inhibition
N-acetylphenethylamine
-
weak
N-acetyltryptamine
-
slight, N-acetyltryptophan does not bind enzyme
N-chloroacetyldopamine
-
strong inhibitor
N-chloroacetylserotonin
-
strong competitive inhibitor
N-chloroserotonin
strong inhibitor
N-lactoyldopamine
-
potent inhibitor
N-pyruvoyldopamine
-
potent inhibitor
n-valeric acid
-
IC50 0.25 mM, pH 6.5
N-[2-chloro-4-(1-ethyl-5-hydroxy-1H-pyrazole-4-carbonyl)-5-methoxyphenyl]-N,N',N'-trimethylsulfuric diamide
-
N2-(3-chlorophenyl)-N-[(1r,4r)-4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)cyclohexyl]-N2-(pyridine-3-sulfonyl)glycinamide
-
NADP+
-
competitive inhibition at fixed concentration with varied NADPH, noncompetitive with varied sepiapterin
NaN3
-
15% inhibition of the reductive reaction at 5 mM; slight
NEM
-
35% inhibition of the reductive reaction at 0.1 mM, 88% at 1 mM
p-chloromercuribenzoate
-
-
p-mercuribenzoate
-
0.1 mM, 93% inhibition
PCMB
-
93% inhibition of the reductive reaction at 0.01 mM
Phenobarbital
-
slight, IC50 0.6 mM
Propionamide
-
0.03 mM, 14% inhibition; 14% inhibition of the reductive reaction at 0.03 mM
pterin
-
0.05 mM: 18% inhibition; 18% inhibition of the reductive reaction at 0.05 mM
pyrazole
-
slight, IC50 1 mM
Pyruvic acid
-
9% inhibition of the reductive reaction at 0.03 mM; slight
Sn2+
-
1 mM inhibits entirely
Xanthopterin-B2
-
12% inhibition of the reductive reaction at 0.05 mM
xanthopterin-H2
-
9% inhibition of the reductive reaction at 0.05 mM
[4-(benzenesulfonyl)piperidin-1-yl](2,4-dichloro-6-hydroxyphenyl)methanone
-
2,4-dinitrophenol
-
37% inhibition of the reductive reaction at 0.01 mM; slight
2,4-dinitrophenol
-
0.1 mM: 89% inhibition
6-Carboxypterin
-
77% inhibition of the reductive reaction at 0.05 mM; IC50 0.014 mM, 0.05 mM: 77% inhibition
6-Carboxypterin
-
IC50 0.03 mM
acetic acid
-
buffers that contain acetate inhibit activity
acetic acid
-
IC50 0.45 mM, pH 6.5
Cd2+
-
1 mM inhibits entirely
Chlorpropamide
noncompetitive; noncompetitive inhibition in sepiapterin reduction and redox cycling
dicoumarol
-
-
dicoumarol
-
IC50 0.0006 mM
dihydrobiopterin
-
0.05 mM: 31% inhibition
dihydrobiopterin
-
non-competitive with NADPH or sepiapterin as varying substrate
Ethacrynic acid
-
Ethacrynic acid
-
IC50 0.03 mM
glibenclamide
noncompetitive inhibition in sepiapterin reduction and redox cycling
indomethacin
-
-
indomethacin
-
IC50 0.06 mM
Isosepiapterin
-
83% inhibition of the reductive reaction at 0.05 mM; IC50 0.0065 mM, 0.05 mM: 83% inhibition
Melatonin
-
-
Melatonin
-
3 mM, almost complete inhibition; strong inhibition
N-acetyldopamine
-
potent competitive inhibitor
N-acetyldopamine
-
very slight
N-acetyldopamine
-
noncompetitive
N-acetylserotonin
-
-
N-acetylserotonin
-
potent competitive inhibitor
N-acetylserotonin
-
very slight
N-acetylserotonin
-
noncompetitive
N-acetylserotonin
-
0.05 mM, 90% inhibition of enzyme from stimulated mononuclear blood cells
N-acetylserotonin
-
activity is completely inhibited by the addition of 0.5 mM N-acetylserotonin
N-acetylserotonin
-
activity is completely inhibited by the addition of 0.5 mM N-acetylserotonin
N-acetylserotonin
-
IC50 0.0006 mM
N-acetylserotonin
-
3 mM, complete inhibition
n-butyric acid
-
IC50 0.032 mM, pH 6.5
N-methoxyacetylserotonin
-
strong competitive inhibitor
N-methoxyacetylserotonin
-
noncompetitive
N-methoxyacetylserotonin
strong competitive inhibitor
NADPH
-
more than 0.05 mM causes substrate inhibition
NADPH
-
product inhibition, with more than 0.1 mM, with 0.05 mM sepiapterin
propionic acid
-
43% inhibition of the reductive reaction at 0.03 mM; IC50 0.0045 mM, pH 6.5
propionic acid
-
IC50 0.3 mM, pH 6.4
QM385
-
rutin
-
sepiapterin
-
above 0.05 mM
sepiapterin
-
product inhibition, with more than 0.05 mM, with 0.1 mM NADPH
SPRi3
-
sulfamethoxazole
noncompetitive; noncompetitive inhibition in sepiapterin reduction and redox cycling
sulfapyridine
noncompetitive; noncompetitive inhibition in sepiapterin reduction and redox cycling
sulfasalazine
i.e. 5-((4-(2-pyridylsulfamoyl) phenyl)azo) salicylic acid or 2-hydroxy-5-[(E)-2-{4-[(pyridin-2-yl)sulfamoyl]phenyl}diazen-1-yl]benzoic acid or SSZ, an FDA-approved salicylate-based anti-inflammatory and immuno-modulatory drug, inhibits sepiapterin reductase. Computational docking of inhibitor sulfasalazine into sepiapterin reductase. The receptor pocket comprises residues Gly11, Ser13, Arg14, Phe16 (region 1), Ala38, Arg39 (region 2), Asn97, Ala98, Gly99, Ser100 (region 3), Tyr167 (region 4), and Leu198, Thr200, Met202 (region 5). Sulfasalazine exhibits an IC50 value of 0.133 mM for SK-N-Be(2)c and 0.337 mM for LAN-5 cells; inhibits the growth of neuroblastoma cells in vitro, presumably due to the inhibition of sepiapterin reductase as predicted by computational docking of sulfasalazine into sepiapterin reductase. The combination of sulfasalazine with alpha-difluoromethylornitine produces synergistic antiproliferative effects in vitro
sulfasalazine
noncompetitive; noncompetitive inhibition in sepiapterin reduction and redox cycling
sulfathiazole
noncompetitive; noncompetitive inhibition in sepiapterin reduction and redox cycling
Tolbutamide
noncompetitive inhibition in sepiapterin reduction and redox cycling
additional information
-
Li+, Na+, Co2+, Mn2+, Ni2+ show slight inhibition at 1 mM
-
additional information
-
other unconjugated pteridines, e.g. xanthopterin, that cause slight inhibition of enzymatic reduction
-
additional information
-
the enzyme activity is not affected by laminar shear stress in endothelial cells, overview
-
additional information
synergism of sulfasalazine and alpha-difluoromethylornithine (DFMO) combination treatment in neuroblastoma cells
-
additional information
-
synergism of sulfasalazine and alpha-difluoromethylornithine (DFMO) combination treatment in neuroblastoma cells
-
additional information
sulfonylurea- or sulfonamide-based drugs inhibit sepiapterin reduction and chemical redox cycling by sepiapterin reductase
-
additional information
-
sulfonylurea- or sulfonamide-based drugs inhibit sepiapterin reduction and chemical redox cycling by sepiapterin reductase
-
additional information
-
no inhibition by 1-epinephrine, phenylalanine, tyrosine, L-DOPA, L-tryptophan, L-5-hydroxy-tryptophan
-
additional information
-
inhibition by specific antibody from rabbits
-
additional information
sulfonylurea- or sulfonamide-based drugs inhibit sepiapterin reduction and chemical redox cycling by sepiapterin reductase
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.00256
(2,4-dichloro-6-hydroxyphenyl)(1,3-dihydro-2H-isoindol-2-yl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00012
(2,4-dichloro-6-hydroxyphenyl)(2,3-dihydro-1H-indol-1-yl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00244
(2,4-dichloro-6-hydroxyphenyl)(2-methyl-2,3-dihydro-1H-indol-1-yl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.01
(2,4-dichloro-6-hydroxyphenyl)(2-methyl-2,6-diazaspiro[3.4]octan-6-yl)methanone
Homo sapiens
IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication
0.00168
(2,4-dichloro-6-hydroxyphenyl)(2-oxa-6-azaspiro[3.4]octan-6-yl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.0051
(2,4-dichloro-6-hydroxyphenyl)(3,3-dimethylpyrrolidin-1-yl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00021
(2,4-dichloro-6-hydroxyphenyl)(3,4-dihydroisoquinolin-2(1H)-yl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00068
(2,4-dichloro-6-hydroxyphenyl)(3,4-dihydroquinolin-1(2H)-yl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00527
(2,4-dichloro-6-hydroxyphenyl)(3-fluoro-3-methylpyrrolidin-1-yl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00052
(2,4-dichloro-6-hydroxyphenyl)(3-phenylpyrrolidin-1-yl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00024
(2,4-dichloro-6-hydroxyphenyl)(4-phenylpiperidin-1-yl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00199
(2,4-dichloro-6-hydroxyphenyl)(pyrrolidin-1-yl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.0006
(2,4-dichloro-6-hydroxyphenyl)[3-(1-methyl-1H-pyrazol-4-yl)pyrrolidin-1-yl]methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00038
(2,4-dichloro-6-hydroxyphenyl)[3-(2-phenylethyl)pyrrolidin-1-yl]methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00079
(2,4-dichloro-6-hydroxyphenyl)[3-(pyridin-2-yl)pyrrolidin-1-yl]methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00037
(2,4-dichloro-6-hydroxyphenyl)[3-(pyridin-3-yl)pyrrolidin-1-yl]methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00062
(2,4-dichloro-6-hydroxyphenyl)[3-(pyridin-4-yl)pyrrolidin-1-yl]methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00131
(2,4-dichloro-6-hydroxyphenyl)[3-(trifluoromethyl)pyrrolidin-1-yl]methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00061
(2,4-dichloro-6-hydroxyphenyl)[3-[(pyridin-3-yl)methyl]pyrrolidin-1-yl]methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00031
(2,4-dichloro-6-hydroxyphenyl)[3-[(pyridin-3-yl)oxy]pyrrolidin-1-yl]methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00055
(2,4-dichloro-6-hydroxyphenyl)[3-[(pyridin-4-yl)methyl]pyrrolidin-1-yl]methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00478
(2-azaspiro[3.4]octan-2-yl)(2,4-dichloro-6-hydroxyphenyl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.0024
(2-azaspiro[4.4]nonan-2-yl)(2,4-dichloro-6-hydroxyphenyl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00585
(2-azaspiro[4.5]decan-2-yl)(2,4-dichloro-6-hydroxyphenyl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00028
(3-anilinopyrrolidin-1-yl)(2,4-dichloro-6-hydroxyphenyl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00074
(3-benzylpyrrolidin-1-yl)(2,4-dichloro-6-hydroxyphenyl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00031
(4-benzylpiperidin-1-yl)(2,4-dichloro-6-hydroxyphenyl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00098
(5-azaspiro[2.4]heptan-5-yl)(2,4-dichloro-6-hydroxyphenyl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.000057
(6-aza-spiro[3.4]oct-6-yl)-(2,4-difluoro-6-hydroxyphenyl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00748
(6-azaspiro[3.4]octan-6-yl)(2,3-dichloro-6-hydroxyphenyl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00157
(6-azaspiro[3.4]octan-6-yl)(2,4-dichloro-3-fluoro-6-hydroxyphenyl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00058
(6-azaspiro[3.4]octan-6-yl)(2,4-dichloro-6-hydroxyphenyl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.01
(6-azaspiro[3.4]octan-6-yl)(2,4-dichloro-6-methoxyphenyl)methanone
Homo sapiens
IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication
0.00067
(6-azaspiro[3.4]octan-6-yl)(2-chloro-4-fluoro-6-hydroxyphenyl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.01
(6-azaspiro[3.4]octan-6-yl)(2-chloro-6-hydroxy-4-methoxyphenyl)methanone
Homo sapiens
IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication
0.01
(6-azaspiro[3.4]octan-6-yl)(2-chloro-6-hydroxy-4-methylphenyl)methanone
Homo sapiens
IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication
0.00145
(6-azaspiro[3.4]octan-6-yl)(2-chloro-6-hydroxyphenyl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.01
(6-azaspiro[3.4]octan-6-yl)(2-fluoro-6-hydroxy-4-methylphenyl)methanone
Homo sapiens
IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication
0.00029
(6-azaspiro[3.4]octan-6-yl)(2-fluoro-6-hydroxyphenyl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.01
(6-azaspiro[3.4]octan-6-yl)(2-hydroxypyridin-3-yl)methanone
Homo sapiens
IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication
0.01
(6-azaspiro[3.4]octan-6-yl)(3,4-dichloro-2-hydroxyphenyl)methanone
Homo sapiens
IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication
0.01
(6-azaspiro[3.4]octan-6-yl)(3,6-dichloro-2-hydroxyphenyl)methanone
Homo sapiens
IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication
0.01
(6-azaspiro[3.4]octan-6-yl)(3-chloro-5-hydroxypyridin-4-yl)methanone
Homo sapiens
IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication
0.00061
(6-azaspiro[3.4]octan-6-yl)(3-hydroxypyridin-2-yl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.01
(6-azaspiro[3.4]octan-6-yl)(3-hydroxypyridin-4-yl)methanone
Homo sapiens
IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication
0.01
(6-azaspiro[3.4]octan-6-yl)(4,5-dichloro-2-hydroxyphenyl)methanone
Homo sapiens
IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication
0.00772
(6-azaspiro[3.4]octan-6-yl)(4-chloro-2-fluoro-6-hydroxyphenyl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.01
(6-azaspiro[3.4]octan-6-yl)(4-chloro-2-hydroxy-6-methylphenyl)methanone
Homo sapiens
IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication
0.00404
(6-azaspiro[3.4]octan-6-yl)(4-chloro-2-hydroxyphenyl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.01
(6-azaspiro[3.4]octan-6-yl)(4-fluoro-2-hydroxyphenyl)methanone
Homo sapiens
IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication
0.01
(6-azaspiro[3.4]octan-6-yl)(4-hydroxypyridin-3-yl)methanone
Homo sapiens
IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication
0.00031
(6-azaspiro[3.4]octan-6-yl)(5-chloro-3-hydroxypyridin-2-yl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00035
(6-azaspiro[3.4]octan-6-yl)(5-fluoro-3-hydroxypyridin-2-yl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00155
(6-azaspiro[3.4]octan-6-yl)(5-hydroxypyrimidin-4-yl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00232
(6-azaspiro[3.4]octan-6-yl)[2-chloro-4-(dimethylamino)-6-hydroxyphenyl]methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.01
(6-azaspiro[3.4]octan-6-yl)[2-chloro-6-hydroxy-4-(trifluoromethyl)phenyl]methanone
Homo sapiens
IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication
0.00046
(6-azaspiro[3.5]nonan-6-yl)(2,4-dichloro-6-hydroxyphenyl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.0089
1,2-naphthoquinone
Homo sapiens
-
wild-type, pH 6.7, 37°C
0.000083
2-(6-azaspiro[3.4]octane-6-sulfonyl)-3,5-dichlorophenol
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00003
2-(6-azaspiro[3.4]octane-6-sulfonyl)-3,5-difluorophenol
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.01
2-(6-azaspiro[3.4]octane-6-sulfonyl)-3-fluorophenol
Homo sapiens
IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication
0.00004
2-(6-azaspiro[3.4]octane-6-sulfonyl)-5-fluorophenol
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.01
4-(6-azaspiro[3.4]octane-6-carbonyl)-3-chloro-5-hydroxybenzamide
Homo sapiens
IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication
0.01
4-(6-azaspiro[3.4]octane-6-carbonyl)-3-chloro-5-hydroxybenzonitrile
Homo sapiens
IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication
0.014 - 0.03
6-Carboxypterin
0.0036
9,10-phenanthrenequinone
Homo sapiens
-
wild-type, pH 6.7, 37°C
5
alpha-ketoglutarate
Rattus norvegicus
-
slight, IC50 5 mM
0.0028
benzoquinone
Homo sapiens
-
wild-type, pH 6.7, 37°C
0.1
Cd2+
Rattus norvegicus
-
IC50 0.1 mM
0.00012 - 0.00037
Chlorpropamide
0.01
Cibacron Blue 3G-A
Rattus norvegicus
-
IC50 0.01 mM
0.0002 - 0.0006
dicoumarol
0.00034 - 0.00111
glibenclamide
0.00009
Hg2+
Rattus norvegicus
-
IC50 0.00009 mM
0.0081 - 0.06
indomethacin
0.0065 - 0.065
Isosepiapterin
0.1
Melatonin
Bombyx mori
-
recombinant enzyme, in 100 mM potassium phosphate buffer (pH 6.4), at 37°C
0.00037
mesalamine
Homo sapiens
pH and temperature not specified in the publication
0.0006 - 0.2
N-acetylserotonin
0.00029
N-acetylsulfapyridine
Homo sapiens
pH and temperature not specified in the publication
0.25
n-valeric acid
Equus caballus
-
IC50 0.25 mM, pH 6.5
0.6
Phenobarbital
Rattus norvegicus
-
slight, IC50 0.6 mM
0.0016
phenylquinone
Homo sapiens
-
wild-type, pH 6.7, 37°C
0.0045 - 0.3
propionic acid
1
pyrazole
Rattus norvegicus
-
slight, IC50 1 mM
0.00000149
QM385
Homo sapiens
pH and temperature not specified in the publication
0.000074
SPRi3
Homo sapiens
pH and temperature not specified in the publication
0.000019 - 0.011
sulfamethoxazole
0.000141 - 0.0194
sulfapyridine
0.0000235 - 0.00053
sulfasalazine
0.000014 - 0.00802
sulfathiazole
0.00051 - 0.00458
Tolbutamide
0.4
Zn2+
Rattus norvegicus
-
IC50 0.4 mM
0.0006
[4-(benzenesulfonyl)piperidin-1-yl](2,4-dichloro-6-hydroxyphenyl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.014
6-Carboxypterin
Equus caballus
-
IC50 0.014 mM, 0.05 mM: 77% inhibition
0.03
6-Carboxypterin
Rattus norvegicus
-
IC50 0.03 mM
0.03
6-Carboxypterin
Homo sapiens
pH and temperature not specified in the publication
0.45
acetic acid
Equus caballus
-
IC50 0.45 mM, pH 6.5
0.45
acetic acid
Homo sapiens
pH and temperature not specified in the publication
0.00012
Chlorpropamide
Homo sapiens
pH not specified in the publication, temperature not specified in the publication
0.00012
Chlorpropamide
Homo sapiens
pH 6.4, 37°C, sepiapterin reduction
0.00037
Chlorpropamide
Homo sapiens
pH 6.4, 37°C, redox cycling
0.0002
dicoumarol
Homo sapiens
-
wild-type, pH 6.7, 37°C
0.0006
dicoumarol
Rattus norvegicus
-
IC50 0.0006 mM
0.0006
dicoumarol
Homo sapiens
pH and temperature not specified in the publication
0.03
Ethacrynic acid
Rattus norvegicus
-
IC50 0.03 mM
0.03
Ethacrynic acid
Homo sapiens
pH and temperature not specified in the publication
0.00034
glibenclamide
Homo sapiens
pH 6.4, 37°C, sepiapterin reduction
0.00111
glibenclamide
Homo sapiens
pH 6.4, 37°C, redox cycling
0.0081
indomethacin
Homo sapiens
-
wild-type, pH 6.7, 37°C
0.06
indomethacin
Rattus norvegicus
-
IC50 0.06 mM
0.06
indomethacin
Homo sapiens
pH and temperature not specified in the publication
0.0065
Isosepiapterin
Equus caballus
-
IC50 0.0065 mM, 0.05 mM: 83% inhibition
0.065
Isosepiapterin
Homo sapiens
pH and temperature not specified in the publication
0.0006
N-acetylserotonin
Rattus norvegicus
-
IC50 0.0006 mM
0.0006
N-acetylserotonin
Homo sapiens
pH and temperature not specified in the publication
0.0026
N-acetylserotonin
Homo sapiens
-
wild-type, pH 6.7, 37°C
0.2
N-acetylserotonin
Bombyx mori
-
recombinant enzyme, in 100 mM potassium phosphate buffer (pH 6.4), at 37°C
0.032
n-butyric acid
Equus caballus
-
IC50 0.032 mM, pH 6.5
0.032
n-butyric acid
Homo sapiens
pH and temperature not specified in the publication
0.0045
propionic acid
Equus caballus
-
IC50 0.0045 mM, pH 6.5
0.045
propionic acid
Homo sapiens
pH and temperature not specified in the publication
0.3
propionic acid
Rattus norvegicus
-
IC50 0.3 mM, pH 6.4
0.06
rutin
Rattus norvegicus
-
IC50 0.06 mM
0.06
rutin
Homo sapiens
pH and temperature not specified in the publication
0.000019
sulfamethoxazole
Homo sapiens
pH and temperature not specified in the publication
0.00018
sulfamethoxazole
Homo sapiens
pH not specified in the publication, temperature not specified in the publication
0.00018
sulfamethoxazole
Homo sapiens
pH 6.4, 37°C, sepiapterin reduction
0.011
sulfamethoxazole
Homo sapiens
pH 6.4, 37°C, redox cycling
0.000141
sulfapyridine
Homo sapiens
pH not specified in the publication, temperature not specified in the publication
0.000141
sulfapyridine
Homo sapiens
pH 6.4, 37°C, sepiapterin reduction
0.00048
sulfapyridine
Homo sapiens
pH and temperature not specified in the publication
0.0194
sulfapyridine
Homo sapiens
pH 6.4, 37°C, redox cycling
0.0000235
sulfasalazine
Homo sapiens
pH and temperature not specified in the publication
0.000031
sulfasalazine
Homo sapiens
pH not specified in the publication, temperature not specified in the publication
0.000031
sulfasalazine
Homo sapiens
pH 6.4, 37°C, sepiapterin reduction
0.00053
sulfasalazine
Homo sapiens
pH 6.4, 37°C, redox cycling
0.000014
sulfathiazole
Homo sapiens
pH and temperature not specified in the publication
0.000062
sulfathiazole
Homo sapiens
pH not specified in the publication, temperature not specified in the publication
0.000062
sulfathiazole
Homo sapiens
pH 6.4, 37°C, sepiapterin reduction
0.00802
sulfathiazole
Homo sapiens
pH 6.4, 37°C, redox cycling
0.00051
Tolbutamide
Homo sapiens
pH 6.4, 37°C, sepiapterin reduction
0.00458
Tolbutamide
Homo sapiens
pH 6.4, 37°C, redox cycling
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Citron, B.A.; Milstien, S.; Gutierrez, J.C.; Levine, R.A.; Yanak, B.L.; Kaufman, S.
Isolation and expression of rat liver sepiapterin reductase cDNA
Proc. Natl. Acad. Sci. USA
87
6436-6440
1990
Rattus norvegicus
brenda
Nagai, M.
Studies on sepiapterin reductase: further characterization of the reaction product
Arch. Biochem. Biophys.
126
426-435
1968
Rattus norvegicus
brenda
Matsubara, M.; Katoh, S.; Akino, M.; Kaufman, S.
Sepiapterin reductase
Biochim. Biophys. Acta
122
202-212
1966
Rattus norvegicus
brenda
Katoh, S.
Sepiapterin reductase from horse liver: purification and properties of the enzyme
Arch. Biochem. Biophys.
146
202-214
1971
Equus caballus, Rattus norvegicus
brenda
Katoh, S.; Arai, Y.; Taketani, T.; Yamada, S.
Sepiapterin reductase in blood of various animals and of leukemic rats
Biochim. Biophys. Acta
370
378-388
1974
Canis lupus familiaris, Cavia porcellus, Gallus gallus, Mus musculus, Oryctolagus cuniculus, Rattus norvegicus, Rattus norvegicus Donryu, Rattus norvegicus Sprague-Dawley, Sus scrofa
brenda
Sueoka, T.; Katoh, S.
Purification and characterization of sepiapterin reductase from rat erythrocytes
Biochim. Biophys. Acta
717
265-271
1982
Rattus norvegicus
brenda
Fere, J.; Naylor, E.W.
Sepiapterin reductase in cultured human cells
Biochem. Biophys. Res. Commun.
148
1475-1481
1987
Homo sapiens
brenda
Werner, E.R.; Werner-Felmayer, G.; Fuchs, D.; Hausen, A.; Reibnegger, G.; Yim, J.J.; Pfleiderer, W.; Wachter, H.
Tetrahydrobiopterin biosynthetic activities in human macrophages, fibroblasts, THP-1, and T 24 cells. GTP-cyclohydrolase I is stimulated by interferon-gamma, and 6-pyruvoyl tetrahydropterin synthase and sepiapterin reductase are constitutively present
J. Biol. Chem.
265
3189-3192
1990
Drosophila melanogaster, Homo sapiens, Drosophila melanogaster Oregon R
brenda
Kerler, F.; Hultner, L.; Ziegler, I.; Katzenmaier, G.; Bacher, A.
Analysis of the tetrahydrobiopterin synthesizing system during maturation of murine reticulocytes
J. Cell. Physiol.
142
268-271
1990
Mus musculus
brenda
Katoh, S.; Sueoka, T.
Isomerization of 6-lactoyl tetrahydropterin by sepiapterin reductase
J. Biochem.
101
275-278
1987
Rattus norvegicus
brenda
Katoh, S.; Sueoka, T.
Sepiapterin reductase exhibits a NADPH-dependent dicarbonyl reductase activity
Biochem. Biophys. Res. Commun.
118
859-866
1984
Rattus norvegicus
brenda
Sueoka, T.; Katoh, S.
Carbonyl reductase activity of sepiapterin reductase from rat erythrocytes
Biochim. Biophys. Acta
843
193-198
1985
Rattus norvegicus
brenda
Curtius, H.C.; Heintel, D.; Ghisla, S.; Kuster, T.; Leimbacher, W.; Niederwieser, A.
Tetrahydrobiopterin biosynthesis. Studies with specifically labeled (2H)NAD(P)H and 2H2O and of the enzymes involved
Eur. J. Biochem.
148
413-419
1985
Homo sapiens
brenda
Katoh, S.; Sueoka, T.; Yamada, S.
Direct inhibition of brain sepiapterin reductase by a catecholamine and an indoleamine
Biochem. Biophys. Res. Commun.
105
75-81
1982
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
brenda
Smith, G.K.
On the role of sepiapterin reductase in the biosynthesis of tetrahydrobiopterin
Arch. Biochem. Biophys.
255
254-266
1987
Rattus norvegicus
brenda
Maier, J.; Ziegler, I.
Purification and properties of human sepiapterin reductase from placenta
Adv. Exp. Med. Biol.
338
199-202
1993
Homo sapiens
brenda
Cho, S.H.; Na, J.U.; Youn, H.; Hwang, C.S.; Lee, C.H.; Kang, S.O.
Sepiapterin reductase producing L-threo-dihydrobiopterin from Chlorobium tepidum
Biochem. J.
340
497-503
1999
Chlorobaculum tepidum
-
brenda
Smith, G.K.; Duch, D.S.; Edelstein, M.P.; Bigham, E.C.
New inhibitors of sepiapterin reductase
J. Biol. Chem.
267
5599-5607
1992
Bos taurus
brenda
Fujimoto, K.; Hara, M.; Yamada, H.; Sakurai, M.; Inaba, A.; Tomomura, A.; Katoh, S.
Role of the conserved Ser-Tyr-Lys triad of the SDR family in sepiapterin reductase
Chem. Biol. Interact.
130-132
825-832
2001
Rattus norvegicus
brenda
Ruiz-Vazquez, P.; Silva, F.J.; Ferre, J.
Characterization of sepiapterin reductase activity from Drosophila melanogaster
Comp. Biochem. Physiol. B
113
131-136
1996
Drosophila melanogaster, Drosophila melanogaster Oregon R
brenda
Kim, Y.A.; Chung, H.J.; Kim, Y.J.; Choi, Y.K.; Hwang, Y.K.; Lee, S.W.; Park, Y.S.
Characterization of recombinant Dictyostelium discoideum sepiapterin reductase expressed in E. coli
Mol. Cells
10
405-410
2000
Dictyostelium discoideum, Phycomyces sp.
brenda
Yoon, K.H.; Cha, K.W.; Park, S.I.; Yim, J.J.
Isolation and characterization of sepiapterin reductase from Drosophila melanogaster
Pteridines
4
43-50
1993
Drosophila melanogaster, Drosophila melanogaster Oregon R
-
brenda
Auerbach, G.; Herrmann, A.; Gutlich, M.; Fischer, M.; Jacob, U.; Bacher, A.; Huber, R.
The 1.25 A crystal structure of sepiapterin reductase reveals its binding mode to pterins and brain neurotransmitters
EMBO J.
16
7219-7230
1997
Mus musculus (Q64105), Mus musculus
brenda
Dowling, T.G.; O'Rourke, J.F.; Tipton, K.F.
Sepiapterin reductase and ALR2 ("aldose reductase") from bovine brain
Adv. Exp. Med. Biol.
328
313-324
1993
Bos taurus
brenda
Ikemoto, K.; Suzuki, T.; Ichinose, H.; Ohye, T.; Nishimura, A.; Nishi, K.; Nagatsu, I.; Nagatsu, T.
Localization of sepiapterin reductase in the human brain
Brain Res.
954
237-246
2002
Homo sapiens, Mus musculus
brenda
Fujimoto, K.; Sakurai, M.; Kawase, M.; Katoh, S.
Effect of antisense oligodeoxynucleotide for sepiapterin reductase on the viability of PC12 cells in the presence of exogenous carbonyl compounds
Chem. Biol. Interact.
143-144
583-586
2003
Rattus norvegicus
brenda
Choi, Y.K.; Jun, S.R.; Cha, E.Y.; Park, J.S.; Park, Y.S.
Sepiapterin reductases from Chlorobium tepidum and Chlorobium limicola catalyze the synthesis of L-threo-tetrahydrobiopterin from 6-pyruvoyltetrahydropterin
FEMS Microbiol. Lett.
242
95-99
2005
Chlorobaculum tepidum, Chlorobium limicola (Q5XPX7), Chlorobium limicola
brenda
Negishi, S.; Fujimoto, K.; Katoh, S.
Localization of sepiapterin reductase in pigment cells of Oryzias latipes
Pigment Cell Res.
16
501-503
2003
Oryzias latipes, Rattus norvegicus
brenda
Supangat, S.; Choi, Y.K.; Park, Y.S.; Son, D.; Han, C.D.; Lee, K.H.
Expression, purification, crystallization and preliminary X-ray analysis of sepiapterin reductase from Chlorobium tepidum
Acta Crystallogr. Sect. F
61
202-204
2005
Chlorobaculum tepidum
brenda
Nagai, M.
Studies on sepiapterin reductase: further characterization of the reaction product
Arch. Biochem. Biophys.
126
420-435
1968
Rattus norvegicus
-
brenda
Choi, Y.K.; Kong, J.S.; Park, Y.S.
Functional role of sepiapterin reductase in the biosynthesis of tetrahydropteridines in Dictyostelium discoideum Ax2
Biochim. Biophys. Acta
1760
877-882
2006
Dictyostelium discoideum, Dictyostelium discoideum AX2
brenda
Choi, Y.K.; Park, J.S.; Kong, J.S.; Morio, T.; Park, Y.S.
D-threo-tetrahydrobiopterin is synthesized via 1-oxo-2-D-hydroxypropyl-tetrahydropterin in Dictyostelium discoideum Ax2
FEBS Lett.
579
3085-3089
2005
Dictyostelium discoideum, Dictyostelium discoideum AX2
brenda
Thoeny, B.; Blau, N.
Mutations in the BH4-metabolizing genes GTP cyclohydrolase I, 6-pyruvoyl-tetrahydropterin synthase, sepiapterin reductase, carbinolamine-4a-dehydratase, and dihydropteridine reductase
Hum. Mutat.
27
870-878
2006
Homo sapiens
brenda
Supangat, S.; Seo, K.H.; Choi, Y.K.; Park, Y.S.; Son, D.; Han, C.D.; Lee, K.H.
Structure of Chlorobium tepidum sepiapterin reductase complex reveals the novel substrate binding mode for stereospecific production of L-threo-tetrahydrobiopterin
J. Biol. Chem.
281
2249-2256
2006
Chlorobaculum tepidum
brenda
Takazawa, C.; Fujimoto, K.; Homma, D.; Sumi-Ichinose, C.; Nomura, T.; Ichinose, H.; Katoh, S.
A brain-specific decrease of the tyrosine hydroxylase protein in sepiapterin reductase-null mice - as a mouse model for Parkinsons disease
Biochem. Biophys. Res. Commun.
367
787-792
2008
Mus musculus
brenda
Tobin, J.E.; Cui, J.; Wilk, J.B.; Latourelle, J.C.; Laramie, J.M.; McKee, A.C.; Guttman, M.; Karamohamed, S.; DeStefano, A.L.; Myers, R.H.
Sepiapterin reductase expression is increased in Parkinsons disease brain tissue
Brain Res.
1139
42-47
2007
Homo sapiens
brenda
Widder, J.D.; Chen, W.; Li, L.; Dikalov, S.; Thoeny, B.; Hatakeyama, K.; Harrison, D.G.
Regulation of tetrahydrobiopterin biosynthesis by shear stress
Circ. Res.
101
830-838
2007
Homo sapiens
brenda
Kim, H.L.; Choi, Y.K.; Kim, d.o..H.; Park, S.O.; Han, J.; Park, Y.S.
Tetrahydropteridine deficiency impairs mitochondrial function in Dictyostelium discoideum Ax2
FEBS Lett.
581
5430-5434
2007
Dictyostelium discoideum
brenda
Sawabe, K.; Yamamoto, K.; Harada, Y.; Ohashi, A.; Sugawara, Y.; Matsuoka, H.; Hasegawa, H.
Cellular uptake of sepiapterin and push-pull accumulation of tetrahydrobiopterin
Mol. Genet. Metab.
94
410-416
2008
Homo sapiens
brenda
Supangat, S.; Park, S.O.; Seo, K.H.; Lee, S.Y.; Park, Y.S.; Lee, K.H.
Role of Phe-99 and Trp-196 of sepiapterin reductase from Chlorobium tepidum in the production of L-threo-tetrahydrobiopterin
Acta Biochim. Biophys. Sin. (Shanghai)
40
513-518
2008
Chlorobaculum tepidum
brenda
Gao, L.; Pung, Y.F.; Zhang, J.; Chen, P.; Wang, T.; Li, M.; Meza, M.; Toro, L.; Cai, H.
Sepiapterin reductase regulation of endothelial tetrahydrobiopterin and nitric oxide bioavailability
Am. J. Physiol. Heart Circ. Physiol.
297
H331-H339
2009
Bos taurus (Q17QK8), Bos taurus
brenda
Hirakawa, H.; Sawada, H.; Yamahama, Y.; Takikawa, S.; Shintaku, H.; Hara, A.; Mase, K.; Kondo, T.; Iino, T.
Expression analysis of the aldo-keto reductases involved in the novel biosynthetic pathway of tetrahydrobiopterin in human and mouse tissues
J. Biochem.
146
51-60
2009
Homo sapiens, Mus musculus
brenda
Meng, Y.; Katsuma, S.; Daimon, T.; Banno, Y.; Uchino, K.; Sezutsu, H.; Tamura, T.; Mita, K.; Shimada, T.
The silkworm mutant lemon (lemon lethal) is a potential insect model for human sepiapterin reductase deficiency
J. Biol. Chem.
284
11698-11705
2009
Bombyx mori
brenda
McHugh, P.C.; Joyce, P.R.; Kennedy, M.R.
Polymorphisms of sepiapterin reductase gene alter promoter activity and may influence risk of bipolar disorder
Pharmacogenet. Genomics
19
330-337
2009
Homo sapiens
brenda
Yang, S.; Jan, Y.H.; Gray, J.P.; Mishin, V.; Heck, D.E.; Laskin, D.L.; Laskin, J.D.
Sepiapterin Reductase Mediates Chemical Redox Cycling in Lung Epithelial Cells
J. Biol. Chem.
288
19221-19237
2013
Homo sapiens
brenda
Lange, I.; Geerts, D.; Feith, D.J.; Mocz, G.; Koster, J.; Bachmann, A.S.
Novel interaction of ornithine decarboxylase with sepiapterin reductase regulates neuroblastoma cell proliferation
J. Mol. Biol.
426
332-346
2014
Homo sapiens (P35270), Homo sapiens
brenda
Tang, Y.; Pei, Z.; Liu, L.; Wang, D.; Kong, L.; Liu, S.; Jiang, X.; Gao, Y.; Ma, H.
Expression and enzyme activity detection of a sepiapterin reductase gene from Musca domestica larva
Appl. Biochem. Biotechnol.
181
604-612
2016
Musca domestica (A0A172EJV6), Musca domestica
brenda
Yco, L.; Geerts, D.; Mocz, G.; Koster, J.; Bachmann, A.
Effect of sulfasalazine on human neuroblastoma: Analysis of sepiapterin reductase (SPR) as a new therapeutic target
BMC Cancer
15
477
2015
Homo sapiens (P35270), Homo sapiens
brenda
Yang, S.; Jan, Y.H.; Mishin, V.; Richardson, J.R.; Hossain, M.M.; Heindel, N.D.; Heck, D.E.; Laskin, D.L.; Laskin, J.D.
Sulfa drugs inhibit sepiapterin reduction and chemical redox cycling by sepiapterin reductase
J. Pharmacol. Exp. Ther.
352
529-540
2015
Rattus norvegicus (P18297), Homo sapiens (P35270), Homo sapiens
brenda
Kim, K.; Kim, H.; Yim, J.
Functional analysis of sepiapterin reductase in Drosophila melanogaster
Pteridines
26
63-68
2015
Drosophila melanogaster
-
brenda
Tang, Y.; Pei, Z.; Liu, L.; Wang, D.; Kong, L.; Liu, S.; Jiang, X.; Gao, Y.; Ma, H.
Expression and enzyme activity detection of a sepiapterin reductase gene from Musca domestica larva
Appl. Biochem. Biotechnol.
181
604-612
2017
Musca domestica (A0A172EJV6), Musca domestica
brenda
Fujita, M.; Scheffer, D.D.L.; Turnes, B.L.; Cronin, S.J.F.; Latremoliere, A.; Costigan, M.; Woolf, C.J.; Latini, A.; Andrews, N.A.
Sepiapterin reductase inhibition selectively reduces inflammatory joint pain and increases urinary sepiapterin
Arthritis Rheumatol.
72
57-66
2020
Mus musculus (Q64105), Mus musculus
brenda
Gao, H.; Schneider, S.; Andrews, P.; Wang, K.; Huang, X.; Sparling, B.A.
Virtual screening to identify potent sepiapterin reductase inhibitors
Bioorg. Med. Chem. Lett.
30
126793
2020
Homo sapiens (P35270)
brenda
Wu, Y.; Chen, P.; Sun, L.; Yuan, S.; Cheng, Z.; Lu, L.; Du, H.; Zhan, M.
Sepiapterin reductase Characteristics and role in diseases
J. Cell. Mol. Med.
24
9495-9506
2020
Homo sapiens (P35270)
brenda
Alen, J.; Schade, M.; Wagener, M.; Christian, F.; Nordhoff, S.; Merla, B.; Dunkern, T.R.; Bahrenberg, G.; Ratcliffe, P.
Fragment-based discovery of novel potent sepiapterin reductase inhibitors
J. Med. Chem.
62
6391-6397
2019
Homo sapiens (P35270), Homo sapiens
brenda
Ranjpour, M.; Wajid, S.; Jain, S.K.
Elevated expression of sepiapterin reductase, regulator of G protein signaling 1, hypothetical protein CXorf58 homolog, and zinc finger and BTB domain-containing protein 21 isoform X2 is associated with progression of hepatocellular carcinoma
Protoplasma
258
1133-1143
2021
Rattus norvegicus (P18297)
brenda