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Literature summary for 1.1.1.153 extracted from

  • Kim, H.L.; Choi, Y.K.; Kim, d.o..H.; Park, S.O.; Han, J.; Park, Y.S.
    Tetrahydropteridine deficiency impairs mitochondrial function in Dictyostelium discoideum Ax2 (2007), FEBS Lett., 581, 5430-5434.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information construction of a mutant disrupted in the gene encoding sepiapterin reductase, the SR mutant produces about 3% of tetrahydropteridines compared to the wild-type and shows several functional defects related to mitochondria and oxidative stress, as retarded growth, poor spore viability, impaired mitochondrial function, and increased susceptibility to oxidative stress induced by hydroxylamine or cumene-hydroperoxide, overview. The physiological defects are almost completely rescued by extrachromosomal expression of the endogenous enzyme Dictyostelium discoideum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6-pyruvoyl-5,6,7,8-tetrahydropterin + NADPH Dictyostelium discoideum
-
tetrahydrobiopterin + NADP+
-
r
additional information Dictyostelium discoideum tetrahydropteridines in Dictyostelium are associated with mitochondrial function, probably via direct protection against oxidative stress, tetrahydropteridine deficiency impairs mitochondrial function in Dictyostelium discoideum Ax2 ?
-
?
sepiapterin + NADPH + H+ Dictyostelium discoideum
-
7,8-dihydrobiopterin + NADP+
-
r

Organism

Organism UniProt Comment Textmining
Dictyostelium discoideum
-
axenic strain Ax2
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6-pyruvoyl-5,6,7,8-tetrahydropterin + NADPH
-
Dictyostelium discoideum tetrahydrobiopterin + NADP+
-
r
additional information tetrahydropteridines in Dictyostelium are associated with mitochondrial function, probably via direct protection against oxidative stress, tetrahydropteridine deficiency impairs mitochondrial function in Dictyostelium discoideum Ax2 Dictyostelium discoideum ?
-
?
additional information the enzyme catalyzes the final step in the tetrahydrobiopterin biosynthesis Dictyostelium discoideum ?
-
?
sepiapterin + NADPH + H+
-
Dictyostelium discoideum 7,8-dihydrobiopterin + NADP+
-
r