Literature summary for 1.1.1.153 extracted from

Gao, H.; Schneider, S.; Andrews, P.; Wang, K.; Huang, X.; Sparling, B.A.
Virtual screening to identify potent sepiapterin reductase inhibitors (2020), Bioorg. Med. Chem. Lett., 30, 126793 .

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Inhibitors

Inhibitors	Comment	Organism
(1s,4s)-4-[(2E)-2-[(4-fluorobenzoyl)imino]-6-[(piperidin-1-yl)methyl]-2,3-dihydro-1H-benzimidazol-1-yl]cyclohexane-1-carboxylic acid	-	Homo sapiens
(2-hydroxy-6-methylpyridin-3-yl)(2-hydroxyphenyl)methanone	-	Homo sapiens
(2-hydroxyphenyl)[3-methyl-1-(pyridin-2-yl)-1H-pyrazolo[3,4-b]pyridin-5-yl]methanone	-	Homo sapiens
(4S)-4-(8-hydroxyquinolin-2-yl)-1-methyl-3-(pyridin-3-yl)-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-b]pyridin-6-one	-	Homo sapiens
2,7,10-trimethyl-9-(4-methyl-2,6-dioxocyclohexane-1-carbonyl)-4,5-dihydro-6lambda6-[1]benzothiepino[5,4-c]pyrazole-6,6(2H)-dione	-	Homo sapiens
3,3'-[(2,4-dichlorophenyl)methylene]di(1H-indole-6-carboxylic acid)	-	Homo sapiens
3-chloro-1-[2-methoxy-4-(trifluoromethyl)phenyl]-N-(1,3-thiazol-2-yl)isoquinoline-6-sulfonamide	-	Homo sapiens
3-hydroxy-4,4-dimethyl-1-oxo-N7-(2-phenylethyl)-1,4-dihydronaphthalene-2,7-dicarboxamide	-	Homo sapiens
3-[1-(3-propyl-1H-pyrazole-5-carbonyl)piperidin-4-yl]-3,4-dihydro-1lambda6,2,4-benzothiadiazine-1,1(2H)-dione	-	Homo sapiens
4-(4-[4-[4-(trifluoromethoxy)phenyl]-4H-1,2,4-triazol-3-yl]piperazin-1-yl)-6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidine	-	Homo sapiens
4-fluoro-N-[(2E)-1-[4-[(propan-2-yl)carbamoyl]cyclohexyl]-6-[(1H-1,2,4-triazol-1-yl)methyl]-1,3-dihydro-2H-benzimidazol-2-ylidene]benzamide	-	Homo sapiens
4-[(1,3-thiazol-2-yl)sulfamoyl]-N-[3-(trifluoromethyl)phenyl]piperidine-1-carboxamide	-	Homo sapiens
4-[2-(pyridin-4-yl)ethyl]-N-(1,3-thiazol-2-yl)-3,4-dihydro-2H-1,4-benzoxazine-7-sulfonamide	-	Homo sapiens
7-(3,4-dihydroxyphenyl)-5-hydroxy-10-(2-hydroxyethyl)-2,2-dimethyl-2H,6H-benzo[1,2-b:5,4-b']dipyran-6-one	-	Homo sapiens
ethyl 6'-chloro-2'-hydroxy-4-(2-methoxy-2-oxoethylidene)-4'-oxo-4'H-spiro[cyclohexane-1,1'-naphthalene]-3'-carboxylate	-	Homo sapiens
ethyl 6-anilino-5-hydroxy-1,2-dimethyl-1H-indole-3-carboxylate	-	Homo sapiens
ethyl N-[(6-bromo-5-methoxy-1-methyl-3-propanoyl-1H-indol-2-yl)methyl]glycinate	-	Homo sapiens
N-(5-fluoropyridin-2-yl)-1-[2-hydroperoxy-4-(trifluoromethyl)phenyl]isoquinoline-6-sulfonamide	-	Homo sapiens
N-(pyridin-2-yl)-2,3-dihydro-1,4-benzodioxine-6-sulfonamide	-	Homo sapiens
N-[2-chloro-4-(1-ethyl-5-hydroxy-1H-pyrazole-4-carbonyl)-5-methoxyphenyl]-N,N',N'-trimethylsulfuric diamide	-	Homo sapiens
N2-(3-chlorophenyl)-N-[(1r,4r)-4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)cyclohexyl]-N2-(pyridine-3-sulfonyl)glycinamide	-	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
sepiapterin + NADPH + H+	Homo sapiens	-	L-erythro-7,8-dihydrobiopterin + NADP+	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P35270	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
sepiapterin + NADPH + H+	-	Homo sapiens	L-erythro-7,8-dihydrobiopterin + NADP+	-	?

Synonyms

Synonyms	Comment	Organism
sepiapterin reductase	-	Homo sapiens
SPR	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
NADPH	-	Homo sapiens