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Literature summary for 1.1.1.153 extracted from

  • Takazawa, C.; Fujimoto, K.; Homma, D.; Sumi-Ichinose, C.; Nomura, T.; Ichinose, H.; Katoh, S.
    A brain-specific decrease of the tyrosine hydroxylase protein in sepiapterin reductase-null mice - as a mouse model for Parkinsons disease (2008), Biochem. Biophys. Res. Commun., 367, 787-792.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information construction of enzyme knockout mice, the SPR null mice show partial lethality and highly reduced tetrahydrobiopterin content, e.g. less than 10% of wild-type levels in the brain, and monoamine contents. Spr-null mice exhibit severe monoamine deficiencies and a tremor-like phenotype after weaning, pteridine contents in the tissues of Spr mutant mice, phenotype, overview Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6-pyruvoyl-5,6,7,8-tetrahydropterin + NADPH Mus musculus
-
tetrahydrobiopterin + NADP+
-
r
sepiapterin + NADPH + H+ Mus musculus
-
7,8-dihydrobiopterin + NADP+
-
r

Organism

Organism UniProt Comment Textmining
Mus musculus
-
wild-type C57BL/6J mice
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6-pyruvoyl-5,6,7,8-tetrahydropterin + NADPH
-
Mus musculus tetrahydrobiopterin + NADP+
-
r
sepiapterin + NADPH + H+
-
Mus musculus 7,8-dihydrobiopterin + NADP+
-
r