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Literature summary for 1.1.1.153 extracted from

  • Katoh, S.; Sueoka, T.
    Sepiapterin reductase exhibits a NADPH-dependent dicarbonyl reductase activity (1984), Biochem. Biophys. Res. Commun., 118, 859-866.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0143
-
2-amino-6-(2-hydroxypropanoyl)pteridin-4(1H)-one pH 6.4, 25°C Rattus norvegicus
0.02
-
benzil pH 6.4, 25°C Rattus norvegicus
0.0218
-
phenylpropanedione
-
Rattus norvegicus
0.0218
-
phenylpropanedione pH 6.4, 25°C Rattus norvegicus
1
-
diacetyl
-
Rattus norvegicus
1
-
diacetyl pH 6.4, 25°C Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6-(S)-lactoyl-7,8-dihydropterin + NADPH Rattus norvegicus
-
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
?
sepiapterin + NADPH + H+ Rattus norvegicus i.e. 2-amino-4-hydroxy-6-lactyl-7,8-dihydropteridine, biosynthesis pathway, overview 7,8-dihydrobiopterin + NADP+ i.e. 2-amino-4-hydroxy-6-(1',2'-dihydroxypropyl-)7,8-dihydropteridine, which is a substrate for biosynthesis of tetrahydrobiopterin, i.e. 6R-L-erythro-1',2'-dihydroxy-propyl-2-amino-4-hydroxy-5,6,7,8-tetrahydropteridine, an important component for controling the concentration of catecholamines or indoleamines in the brain and other nerve tissues ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus
native enzyme from erythrocytes Rattus norvegicus

Reaction

Reaction Comment Organism Reaction ID
L-erythro-7,8-dihydrobiopterin + NADP+ = sepiapterin + NADPH + H+ enzyme also reduces carbonyl compounds of non-pteridine derivatives Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Rattus norvegicus
-
erythrocyte
-
Rattus norvegicus
-
nerve
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-phenyl-1,2-propanedione + NADPH
-
Rattus norvegicus ?
-
?
2,3-butanediol + NADP+
-
Rattus norvegicus ?
-
?
2-amino-6-(2-hydroxypropanoyl)pteridin-4(1H)-one + NADPH + H+
-
Rattus norvegicus ?
-
r
6-(S)-lactoyl-7,8-dihydropterin + NADPH
-
Rattus norvegicus 6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
?
9,10-phenanthrenequinone + NADP+
-
Rattus norvegicus ?
-
?
acetoin + NADPH 0.003 mM NADPH oxidised per 30 min Rattus norvegicus ?
-
?
benzil + NADPH
-
Rattus norvegicus ?
-
?
benzil + NADPH NADPH-dependent dicarbonyl reductase activity Rattus norvegicus ?
-
?
diacetyl + NADPH
-
Rattus norvegicus ?
-
?
diacetyl + NADPH NADPH-dependent dicarbonyl reductase activity Rattus norvegicus acetoin + NADP+
-
?
additional information some monoketotestosterones show slight activity Rattus norvegicus ?
-
?
additional information substrate specificity, the enzyme also exhibits non-specific NADPH-dependent dicarbonyl reductase activity, overview Rattus norvegicus ?
-
?
phenylpropanedione + NADPH NADPH-dependent dicarbonyl reductase activity Rattus norvegicus phenylpropan-2,3-diol + NADP+
-
?
sepiapterin + NADPH + H+ i.e. 2-amino-4-hydroxy-6-lactyl-7,8-dihydropteridine, biosynthesis pathway, overview Rattus norvegicus 7,8-dihydrobiopterin + NADP+ i.e. 2-amino-4-hydroxy-6-(1',2'-dihydroxypropyl-)7,8-dihydropteridine, which is a substrate for biosynthesis of tetrahydrobiopterin, i.e. 6R-L-erythro-1',2'-dihydroxy-propyl-2-amino-4-hydroxy-5,6,7,8-tetrahydropteridine, an important component for controling the concentration of catecholamines or indoleamines in the brain and other nerve tissues ?
sepiapterin + NADPH + H+ sepiapterin reductase activity Rattus norvegicus 7,8-dihydrobiopterin + NADP+
-
?

Synonyms

Synonyms Comment Organism
SPR
-
Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
assay at, sepiapterin reductase activity Rattus norvegicus
37
-
assay at, NADPH-dependent dicarbonyl reductase activity Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.4
-
assay at, sepiapterin reductase activity Rattus norvegicus
6.8
-
assay at, NADPH-dependent dicarbonyl reductase activity Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Rattus norvegicus