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2.3.1.286: protein acetyllysine N-acetyltransferase

This is an abbreviated version!
For detailed information about protein acetyllysine N-acetyltransferase, go to the full flat file.

Word Map on EC 2.3.1.286

Reaction

[protein]-N6-acetyl-L-lysine
+
NAD+
 +
H2O
=
[protein]-L-lysine
 +
2''-O-acetyl-ADP-D-ribose
 +
nicotinamide

Synonyms

Af2Sir2, Clr3, CobB, HDAC, histone deacetylase, Hst1, HST2, Hst2p, KAT, More, NAD+-dependent protein deacetylase, NAD-dependent histone deacetylase, NAD-dependent protein deacetylase, nicotinamide adenine dinucleotide-dependent protein deacetylase, patZ, peptidyl-lysine N-acetyltransferase, phnO, protein lysine acetyltransferase, protein lysine deacetylase, Rv1151c, silent information regulator 2, Sir-2, Sir2, SIR2-Af1, Sir2-Af2, Sir2A, Sir2Af2, Sir2alpha, Sir2p, SIRT1, SIRT2, SIRT3, SIRT5, sirtuin, sirtuin 1, sirtuin 3, sirtuin-2 deacetylase, YfiQ, YiaC, YjaB

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.286 protein acetyllysine N-acetyltransferase

Natural Substrates Products

Natural Substrates Products on EC 2.3.1.286 - protein acetyllysine N-acetyltransferase

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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
acetyl-CoA + [protein]-L-lysine
CoA + [protein]-N6-acetyl-L-lysine
show the reaction diagram
-
-
-
?
hyperacetylated histone-DNA complex + NAD+ + H2O
deacetylated nuclease-resistant histone-DNA complex + ?
show the reaction diagram
-
-
-
?
NAD+ + [alpha-tubulin]-N6-acyl-L-lysine
nicotinamide + [alpha-tubulin]-L-lysine + 2'-O-acyl-ADP-ribose
show the reaction diagram
NAD+ + [BMAL1 protein]-N6-acyl-L-lysine
nicotinamide + [BMAL1 protein]-L-lysine + 2'-O-acyl-ADP-ribose
show the reaction diagram
NAD+ + [chicken erythrocyte histone]-N6-acetyl-L-lysine
nicotinamide + [protein]-L-lysine + 2'-O-acetyl-ADP ribose
show the reaction diagram
-
-
-
?
NAD+ + [DNA repair factor Ku70]-N6-acetyl-L-lysine382
nicotinamide + [DNA repair factor Ku70]-L-lysine382 + 2'-O-acetyl-ADP-ribose
show the reaction diagram
NAD+ + [Fluor de Lys protein]-N6-acyl-L-lysine
nicotinamide + [Fluor de Lys protein]-L-lysine + 2'-O-acyl-ADP-ribose
show the reaction diagram
-
-
-
-
?
NAD+ + [glutamate dehydrogenase]-N6-acetyl-L-lysine
nicotinamide + [glutamate dehydrogenase]-L-lysine + 2'-O-acetyl-ADP-ribose
show the reaction diagram
Sirt3 can deacetylate and thereby activate a central metabolic regulator in the mitochondrial matrix, glutamate dehydrogenase
-
-
?
NAD+ + [glutamate oxaloacetate transaminase 2]-N6-acetyl-L-lysine
nicotinamide + [glutamate oxaloacetate transaminase 2]-L-lysine + 2'-O-acyl-ADP-ribose
show the reaction diagram
isoform SIRT3 is the major deacetylase of glutamate oxaloacetate transaminase 2
-
-
?
NAD+ + [heat shock protein 10]-N6-acetyl-L-lysine56
nicotinamide + [heat shock protein 10]-L-lysine + 2'-O-acetyl-ADP-ribose
show the reaction diagram
-
-
-
?
NAD+ + [histone H4]-N6-acetyl-L-lysine16
nicotinamide + [histone H4]-L-lysine16 + 2'-O-acetyl-ADP-ribose
show the reaction diagram
the deacetylation of [histone H4]-N6-acetyl-L-lysine16 may be pivotal to the formation of condensed chromatin
-
-
?
NAD+ + [isocitrate dehydrogenase 2]-N6-acetyl-L-lysine
nicotinamide + [isocitrate dehydrogenase 2]-L-lysine + 2'-O-acetyl-ADP-ribose
show the reaction diagram
Sirt3 can deacetylate and activate isocitrate dehydrogenase 2, an enzyme that promotes regeneration of antioxidants and catalyzes a key regulation point of the citric acid cycle
-
-
?
NAD+ + [isocitrate dehydrogenase 2]-N6-acetyl-L-lysine413
nicotinamide + [isocitrate dehydrogenase 2]-L-lysine413 + 2'-O-acetyl-ADP-ribose
show the reaction diagram
acetylation of Lys413 decreases catalysis and SIRT3 reactivates isocitrate dehydrogenase 2 upon deacetylation
-
-
?
NAD+ + [nuclear receptor LXR]-N6-acetyl-L-lysine
nicotinamide + [nuclear receptor LXR]-L-lysine + 2'-O-acetyl-ADP ribose
show the reaction diagram
Q96EB6
SIRT1 positively regulates liver X receptors (LXRs) by deacetylation at lysine. Deacetylation of liver X receptors (LXRs) by SIRT1 may be a mechanism that affects atherosclerosis and other agingassociated diseases
-
-
?
NAD+ + [p53 protein]-N6-acetyl-L-lysine
nicotinamide + [p53 protein]-L-lysine + 2'-O-acetyl-ADP-ribose
show the reaction diagram
Q96EB6
SIRT1 deacetylase is a negative regulator of p53 function capable of modulating cellular senescence
-
-
?
NAD+ + [p53 protein]-N6-acetyl-L-lysine382
nicotinamide + [p53 protein]-L-lysine382 + 2'-O-acetyl-ADP ribose
show the reaction diagram
Q96EB6
Sir2 is involved in the regulation of p53 function via deacetylation
-
-
?
NAD+ + [PER2 protein]-N6-acetyl-L-lysine
nicotinamide + [PER2 protein]-L-lysine + 2'-O-acetyl-ADP-ribose
show the reaction diagram
Q96EB6
SIRT1 regulates circadian clock gene expression through PER2 deacetylation
-
-
?
NAD+ + [protein]-N6-acetyl-L-lysine
nicotinamide + [protein]-L-lysine + 2'-O-acetyl-ADP-ribose
show the reaction diagram
-
-
-
?
NAD+ + [protein]-N6-acyl-L-lysine
nicotinamide + [protein]-L-lysine + 2'-O-acyl-ADP-ribose
show the reaction diagram
NAD+ + [protein]-N6-myristoyl-L-lysine
nicotinamide + [protein]-L-lysine + 2'-O-myristoyl-ADP-ribose
show the reaction diagram
demyristoylase activity of SIRT2 is 5fold more efficient than its deacetylase activity
-
-
?
NAD+ + [protein]-N6-succinyl-L-lysine
nicotinamide + [protein]-L-lysine + 2'-O-succinyl-ADP-ribose
show the reaction diagram
Q8IXJ6, Q96EB6, Q9NTG7
-
-
-
?
NAD+ + [SREBP-1c]-N6-acetyl-L-lysine
nicotinamide + [SREBP-1c]-L-lysine + 2'-O-acetyl-ADP ribose
show the reaction diagram
Q923E4
SREBP-1c is a key lipogenic activator. Deacetylation of SREBP-1c by SIRT1 inhibits SREBP-1c activity by decreasing its stability and its association with its lipogenic target gene promoters
-
-
?
NAD+ + [thymine DNA glycosylase]-N6-acetyl-L-lysine
nicotinamide + [thymine DNA glycosylase]-L-lysine + 2'-O-acetyl-ADP-ribose
show the reaction diagram
Q96EB6
deacetylation and stimulation of the thymine DNA glycosylase activity by SIRT1 enhances DNA demethylation
-
-
?
NAD+ + [very long-chain acyl-CoA dehydrogenase]-N6-acetyl-L-lysine
nicotinamide + [very long-chain acyl-CoA dehydrogenase]-L-lysine + 2'-O-acetyl-ADP-ribose
show the reaction diagram
-
-
-
?
[Acs protein]-N6-acetyl-L-lysine609 + NAD+ + H2O
[Acs protein]-L-lysine609 + 2''-O-acetyl-ADP-D-ribose + nicotinamide
show the reaction diagram
-
the enzyme activates Acs protein by deacetylation
-
-
?
[Alba protein]-N6-acetyl-L-lysine16 + NAD+ + H2O
[Alba protein]-L-lysine16 + 2''-O-acetyl-ADP-D-ribose + nicotinamide
show the reaction diagram
[protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide
[protein]-N6-acetyl-L-lysine + NAD+ + H2O
show the reaction diagram
[protein]-N6-acetyl-L-lysine + NAD+
[protein]-N6-[1,1-(5-adenosylyl-alpha-D-ribose-1,2-di-O-yl)ethyl]-L-lysine + nicotinamide
show the reaction diagram
[protein]-N6-acetyl-L-lysine + NAD+ + H2O
[protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide
show the reaction diagram
[protein]-N6-[1,1-(5-adenosylyl-alpha-D-ribose-1,2-di-O-yl)ethyl]-L-lysine + H2O
[protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose
show the reaction diagram
additional information
?
-