2.3.1.286: protein acetyllysine N-acetyltransferase
This is an abbreviated version!
For detailed information about protein acetyllysine N-acetyltransferase, go to the full flat file.
Word Map on EC 2.3.1.286
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2.3.1.286
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deacetylation
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resveratrol
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nad+-dependent
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nicotinamide
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deacetylases
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endothelial
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longevity
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peroxisome
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cardiac
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tnf
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obesity
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proliferator-activated
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cardiovascular
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dismutase
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neurodegenerative
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chromatin
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neuroprotective
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lifespan
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sirna
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myocardial
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amp-activated
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fibrosis
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adipose
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polyphenolic
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high-fat
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cardiomyocytes
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forkhead
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calorie
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alzheimer
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hdacs
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obese
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adipocytes
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sod2
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steatosis
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caspase-3
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nafld
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cardioprotective
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foxo3a
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senescence-associated
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aging-related
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mir-34a
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hyperacetylation
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anti-aging
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nampt
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tfam
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mnsod
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p-ampk
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monophosphate-activated
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coactivator-1
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non-histone
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medicine
- 2.3.1.286
-
deacetylation
- resveratrol
-
nad+-dependent
- nicotinamide
- deacetylases
- endothelial
-
longevity
- peroxisome
- cardiac
- tnf
- obesity
-
proliferator-activated
- cardiovascular
- dismutase
- neurodegenerative
- chromatin
-
neuroprotective
-
lifespan
- sirna
- myocardial
-
amp-activated
- fibrosis
- adipose
-
polyphenolic
-
high-fat
- cardiomyocytes
-
forkhead
-
calorie
- alzheimer
- hdacs
-
obese
- adipocytes
- sod2
- steatosis
- caspase-3
- nafld
-
cardioprotective
-
foxo3a
-
senescence-associated
-
aging-related
-
mir-34a
-
hyperacetylation
-
anti-aging
- nampt
- tfam
- mnsod
-
p-ampk
-
monophosphate-activated
- coactivator-1
-
non-histone
- medicine
Reaction
Synonyms
Af2Sir2, Clr3, CobB, HDAC, histone deacetylase, Hst1, HST2, Hst2p, KAT, More, NAD+-dependent protein deacetylase, NAD-dependent histone deacetylase, NAD-dependent protein deacetylase, nicotinamide adenine dinucleotide-dependent protein deacetylase, patZ, peptidyl-lysine N-acetyltransferase, phnO, protein lysine acetyltransferase, protein lysine deacetylase, Rv1151c, silent information regulator 2, Sir-2, Sir2, SIR2-Af1, Sir2-Af2, Sir2A, Sir2Af2, Sir2alpha, Sir2p, SIRT1, SIRT2, SIRT3, SIRT5, sirtuin, sirtuin 1, sirtuin 3, sirtuin-2 deacetylase, YfiQ, YiaC, YjaB
ECTree
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Localization
Localization on EC 2.3.1.286 - protein acetyllysine N-acetyltransferase
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Q96EB6
SIRT1 and p53 colocalize in nuclear bodies (punctate structures found in the nuclei of certain cells) upon upregulation of the promyelocytic leukemia protein
the enzyme is cytoplasmic during most of the cell cycle except in the G2/M transition and in mitosis
SIRT3 is localized to the inner membrane of the mitochondria
Sirt5 can be translocated into the mitochondrial intermembrane space, but also into the matrix
in the G2/M transition and in mitosis the enzyme is localized in association with chromatin