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2.3.1.286: protein acetyllysine N-acetyltransferase

This is an abbreviated version!
For detailed information about protein acetyllysine N-acetyltransferase, go to the full flat file.

Word Map on EC 2.3.1.286

Reaction

[protein]-N6-acetyl-L-lysine
+
NAD+
 +
H2O
=
[protein]-L-lysine
 +
2''-O-acetyl-ADP-D-ribose
 +
nicotinamide

Synonyms

Af2Sir2, Clr3, CobB, HDAC, histone deacetylase, Hst1, HST2, Hst2p, KAT, More, NAD+-dependent protein deacetylase, NAD-dependent histone deacetylase, NAD-dependent protein deacetylase, nicotinamide adenine dinucleotide-dependent protein deacetylase, patZ, peptidyl-lysine N-acetyltransferase, phnO, protein lysine acetyltransferase, protein lysine deacetylase, Rv1151c, silent information regulator 2, Sir-2, Sir2, SIR2-Af1, Sir2-Af2, Sir2A, Sir2Af2, Sir2alpha, Sir2p, SIRT1, SIRT2, SIRT3, SIRT5, sirtuin, sirtuin 1, sirtuin 3, sirtuin-2 deacetylase, YfiQ, YiaC, YjaB

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.286 protein acetyllysine N-acetyltransferase

IC50 Value

IC50 Value on EC 2.3.1.286 - protein acetyllysine N-acetyltransferase

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0144
(5E)-5-[4-(benzyloxy)benzylidene]-1-ethyl-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
Homo sapiens
Q8IXJ6, Q96EB6, Q9NTG7
pH 8.0, 37°C
0.01
(5E)-5-[4-(benzyloxy)benzylidene]-1-methyl-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
Homo sapiens
Q8IXJ6, Q96EB6, Q9NTG7
pH 8.0, 37°C
0.0097
(5E)-5-[[5-(2,3-dichlorophenyl)furan-2-yl]methylidene]-1-(prop-2-en-1-yl)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
Homo sapiens
Q8IXJ6, Q96EB6, Q9NTG7
pH 8.0, 37°C
0.0102
2-(N-(4-chlorophenyl)-N-methylsulfamoyl)-N-(4-cyano-2-fluorophenyl)isonicotinamide
Homo sapiens
pH and temperature not specified in the publication
0.0049
2-(N-(4-chlorophenyl)-N-methylsulfamoyl)-N-(4-cyanophenyl)isonicotinamide
Homo sapiens
pH and temperature not specified in the publication
0.0008 - 0.0037
2-[1-[3-(amidinothio)propyl]-1H-indol-3-yl]-3-(1-methylindol-3-yl)maleimide methanesulfonate
0.0172
3-((2-methoxynaphthalen-1-yl)methyl)-7-((2-methylbenzyl)amino)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one
Homo sapiens
pH 7.5, temperature not specified in the publication
0.00145
3-((2-methoxynaphthalen-1-yl)methyl)-7-((pyridin-3-ylmethyl)amino)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one
Homo sapiens
pH 7.5, temperature not specified in the publication
0.006
3-((2-methoxynaphthalen-1-yl)methyl)-7-((thiophen-2-ylmethyl)-amino)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one
Homo sapiens
pH 7.5, temperature not specified in the publication
0.00652
3-((2-methoxynaphthalen-1-yl)methyl)-7-(neopentylamino)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one
Homo sapiens
pH 7.5, temperature not specified in the publication
0.0108
3-(azepan-1-ylsulfonyl)-N-(3-nitrophenyl)benzamide
Homo sapiens
pH and temperature not specified in the publication
0.0068
3-(N-(4-acetylphenyl)-N-methylsulfamoyl)-N-(4-chlorophenyl)benzamide
Homo sapiens
pH and temperature not specified in the publication
0.0073
3-(N-(4-acetylphenyl)-N-methylsulfamoyl)-N-(4-cyanophenyl)benzamide
Homo sapiens
pH and temperature not specified in the publication
0.0132
3-(N-(4-acetylphenyl)-N-methylsulfamoyl)-N-(5-chloropyridin-2-yl)benzamide
Homo sapiens
pH and temperature not specified in the publication
0.0075
3-(N-(4-bromophenyl)-N-methylsulfamoyl)-N-(4-chloro-2-fluorophenyl)-N-methylbenzamide
Homo sapiens
pH and temperature not specified in the publication
0.0095
3-(N-(4-chlorophenyl)-N-methylsulfamoyl)-N-(4-(methylsulfinyl)phenyl)benzamide
Homo sapiens
pH and temperature not specified in the publication
0.0098
3-(N-(4-chlorophenyl)-N-methylsulfamoyl)-N-(4-(methylsulfonyl)phenyl)benzamide
Homo sapiens
pH and temperature not specified in the publication
0.0066
3-(N-(4-chlorophenyl)-N-methylsulfamoyl)-N-(4-cyano-2-fluorophenyl)benzamide
Homo sapiens
pH and temperature not specified in the publication
0.0061
3-(N-(4-chlorophenyl)-N-methylsulfamoyl)-N-(4-cyanophenyl)benzamide
Homo sapiens
pH and temperature not specified in the publication
0.0199
3-(N-(4-chlorophenyl)-N-methylsulfamoyl)-N-(5-cyanopyridin-2-yl)benzamide
Homo sapiens
pH and temperature not specified in the publication
0.0091
3-(N-(4-chlorophenyl)-N-methylsulfamoyl)-N-(5-fluoropyridin-2-yl)benzamide
Homo sapiens
pH and temperature not specified in the publication
0.0156
3-(N-(4-chlorophenyl)-N-methylsulfamoyl)-N-(6-chloropyridazin-3-yl)benzamide
Homo sapiens
pH and temperature not specified in the publication
0.0061
3-(N-(5-chloropyridin-2-yl)-N-methylsulfamoyl)-N-(4-cyanophenyl)benzamide
Homo sapiens
pH and temperature not specified in the publication
0.0063
4-bromo-N-(3-(N-methyl-N-(4-(methylsulfonyl)phenyl)sulfamoyl)phenyl)benzamide
Homo sapiens
pH and temperature not specified in the publication
0.0203
5-(1H-indol-3-ylmethylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
Homo sapiens
Q8IXJ6, Q96EB6, Q9NTG7
pH 8.0, 37°C
0.0087 - 0.0403
5-(biphenyl-4-ylmethylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
0.116
5-[(1-benzyl-1H-indol-3-yl)methylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
Homo sapiens
Q8IXJ6, Q96EB6, Q9NTG7
pH 8.0, 37°C
0.0117 - 0.0433
5-[(6-methoxynaphthalen-1-yl)methylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
0.0098 - 0.0293
5-[4-(benzyloxy)benzylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
0.0147
5-[4-(propan-2-yl)benzylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
Homo sapiens
Q8IXJ6, Q96EB6, Q9NTG7
pH 8.0, 37°C
0.0075 - 0.0464
5-[4-[(2-chlorobenzyl)oxy]-3-methoxybenzylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
0.0034 - 0.0303
5-[4-[(4-bromobenzyl)oxy]benzylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
0.0104
5-[[5-(2,3-dichlorophenyl)furan-2-yl]methylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
Homo sapiens
Q8IXJ6, Q96EB6, Q9NTG7
pH 8.0, 37°C
0.0001 - 0.049
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
0.004
7-((3-fluorobenzyl)amino)-3-((2-methoxynaphthalen-1-yl)methyl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one
Homo sapiens
pH 7.5, temperature not specified in the publication
0.0019
7-((3-methoxybenzyl)amino)-3-((2-methoxynaphthalen-1-yl)-methyl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one
Homo sapiens
pH 7.5, temperature not specified in the publication
0.0211
7-(benzylamino)-3-((2-methoxynaphthalen-1-yl)methyl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one
Homo sapiens
pH 7.5, temperature not specified in the publication
0.056 - 0.059
cambinol
12200 - 13800
Isonicotinamide
0.0038
N-(3-(N-(4-chlorophenyl)-N-methylsulfamoyl)phenyl)-4-cyanobenzamide
Homo sapiens
pH and temperature not specified in the publication
0.0189
N-(4-acetylphenyl)-3-(N-(4-acetylphenyl)-N-methylsulfamoyl)benzamide
Homo sapiens
pH and temperature not specified in the publication
0.0069
N-(4-bromo-2-fluorophenyl)-3-(N-(4-bromophenyl)-N-methylsulfamoyl)-N-methylbenzamide
Homo sapiens
pH and temperature not specified in the publication
0.0159
N-(4-chlorophenyl)-3-(N-methyl-N-(4-(methylsulfonyl)phenyl)sulfamoyl)benzamide
Homo sapiens
pH and temperature not specified in the publication
0.0115
N-(4-cyanophenyl)-3-(N-(4-(1-hydroxyethyl)phenyl)-N-methylsulfamoyl)benzamide
Homo sapiens
pH and temperature not specified in the publication
0.0094
N-(4-cyanophenyl)-3-(N-(4-fluorophenyl)-N-methylsulfamoyl)benzamide
Homo sapiens
pH and temperature not specified in the publication
0.0096
N-(4-cyanophenyl)-3-(N-(4-methoxyphenyl)-N-methylsulfamoyl)benzamide
Homo sapiens
pH and temperature not specified in the publication
0.0095
N-(4-cyanophenyl)-3-(N-methyl-N-(4-(methylsulfonyl)phenyl)sulfamoyl)benzamide
Homo sapiens
pH and temperature not specified in the publication
0.0012 - 0.1
nicotinamide
0.037 - 0.131
sirtinol
0.0003 - 0.02
suramin
0.132
[histone H3]-difluoroacetyl-L-lysine
Saccharomyces cerevisiae
-
at pH 7.5 and 25°C
-
0.133
[histone H3]-monofluoroacetyl-L-lysine
Saccharomyces cerevisiae
-
at pH 7.5 and 25°C
-
0.00102
[histone H3]-thioacetyl-L-lysine
Saccharomyces cerevisiae
-
at pH 7.5 and 25°C
-
0.061
[histone H3]-trifluoroacetyl-L-lysine
Saccharomyces cerevisiae
-
at pH 7.5 and 25°C