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1.14.14.94: leukotriene-B4 20-monooxygenase

This is an abbreviated version!
For detailed information about leukotriene-B4 20-monooxygenase, go to the full flat file.

Word Map on EC 1.14.14.94

Reaction

(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate
+
[reduced NADPH-hemoprotein reductase]
 +
O2
=
(6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate
 +
[oxidized NADPH-hemoprotein reductase]
 +
H2O

Synonyms

CYP4 omega-hydroxylase, CYP4A11, CYP4F11, CYP4F12, CYP4F13, CYP4F14, CYP4F15, CYP4F16, CYP4F17, CYP4F18, CYP4F2, CYP4F3, CYP4F37, CYP4F39, CYP4F3A, CYP4F3B, CYP4F4, CYP4F40, CYP4F8, CYPIVF2, CYPIVF3, cytochrome CYP4F3A, cytochrome P-450 4F18, cytochrome P450 4F2, cytochrome P450 4F3, Cytochrome P450-LTB-omega, EC 1.14.13.30, leukotriene B4 20-hydroxylase, leukotriene B4 omega-1/omega-2 hydroxylase, leukotriene B4 omega-hydroxylase, Leukotriene-B4 20-monooxygenase, leukotriene-B4 omega-hydroxylase, LTB4 20-hydroxylase, LTB4 hydroxylase, LTB4 omega hydroxylase, LTB4 omega-hydroxylase, LTB4OH, More, oxygenase, leukotriene B4 20-mono-, TOH-omega-hydroxylase, vitamin E-omega-hydroxylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.14.94 leukotriene-B4 20-monooxygenase

Source Tissue

Source Tissue on EC 1.14.14.94 - leukotriene-B4 20-monooxygenase

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
ex-smokers express significantly higher LTB4OH mRNA levels than smokers
Manually annotated by BRENDA team
-
bone marrow-derived, in vitro differentiation
Manually annotated by BRENDA team
-
CYP4F11
Manually annotated by BRENDA team
-
constitutively expressed in hepatoma cell line Hep-G2
Manually annotated by BRENDA team
-
CYP4F3B is the predominant CYP4F isoform
Manually annotated by BRENDA team
-
exhibits greater leukotriene B4 hydroxylase activities than fresh skin tissues of either species
Manually annotated by BRENDA team
-
CYP4F3 is specifically expressed in. CYP4F3 is restricted to myeloid cells
Manually annotated by BRENDA team
-
mRNA for CYP4F8 detected
Manually annotated by BRENDA team
additional information