1.14.14.94: leukotriene-B4 20-monooxygenase

This is an abbreviated version!
For detailed information about leukotriene-B4 20-monooxygenase, go to the full flat file.

Word Map on EC 1.14.14.94

1.14.14.94

warfarin

vkorc1

cyp2c9

anticoagulant

arachidonic

dosing

pharmacogenetic

20-hete

20-hydroxyeicosatetraenoic

cyp4fs

cyp4a11

omega-hydroxylation

epoxide

eicosanoids

cyp3a5

interindividual

acenocoumarol

pharmacogenomics

thromboembolic

non-genetic

cyp1b1

omega-oxidation

17-octadecynoic

epoxyeicosatrienoic

pharmacogenes

genotype-guided

lipoxins

Reaction

(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate

(6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate

Synonyms

CYP4 omega-hydroxylase, CYP4A11, CYP4F11, CYP4F12, CYP4F13, CYP4F14, CYP4F15, CYP4F16, CYP4F17, CYP4F18, CYP4F2, CYP4F3, CYP4F37, CYP4F39, CYP4F3A, CYP4F3B, CYP4F4, CYP4F40, CYP4F8, CYPIVF2, CYPIVF3, cytochrome CYP4F3A, cytochrome P-450 4F18, cytochrome P450 4F2, cytochrome P450 4F3, Cytochrome P450-LTB-omega, EC 1.14.13.30, leukotriene B4 20-hydroxylase, leukotriene B4 omega-1/omega-2 hydroxylase, leukotriene B4 omega-hydroxylase, Leukotriene-B4 20-monooxygenase, leukotriene-B4 omega-hydroxylase, LTB4 20-hydroxylase, LTB4 hydroxylase, LTB4 omega hydroxylase, LTB4 omega-hydroxylase, LTB4OH, More, oxygenase, leukotriene B4 20-mono-, TOH-omega-hydroxylase, vitamin E-omega-hydroxylase

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

1.14.14.94 leukotriene-B4 20-monooxygenase

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Results	in table
7	Activating Compound
25	AA Sequence
1	Application
1	CAS Registry Number
18	Cloned(Commentary)
7	Cofactor
446	Disease/ Diagnostics
4	Expression
4	General Information
16	Inhibitors
3	Ki Value [mM]
41	KM Value [mM]
16	Localization
2	Metals/Ions
6	Molecular Weight [Da]
27	Natural Substrates/ Products (Substrates)
36	Organism
3	Pathway
7	pH Optimum
1	pH Range
5	Protein Variants
5	Purification (Commentary)
2	Reaction
3	Reaction Type
32	Reference
65	Source Tissue
2	Specific Activity [micromol/min/mg]
5	Storage Stability
99	Substrates and Products (Substrate)
1	Subunits
75	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
1	Temperature Stability [°C]

KM Value

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KM Value on EC 1.14.14.94 - leukotriene-B4 20-monooxygenase

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0.0142 - 0.0752

12-hydroxy-5,8,10,14-eicosatetraenoic acid

2 entries

0.0409 - 0.0423

12-hydroxystearate

2 entries

0.0065

20-hydroxy-leukotriene B4

Homo sapiens

658922

0.0056

5-Deoxy-leukotriene B4

Homo sapiens

390067

0.0066

5-epi-Leukotriene B4

Homo sapiens

390067

0.0038

6-trans-12-epi-Leukotriene B4

Homo sapiens

390067

0.0556 - 0.0961

6-trans-leukotriene B4

3 entries

0.00022 - 0.868

leukotriene B4

15 entries

0.0582 - 0.254

lipoxin A4

2 entries

0.0179

lipoxin B4

Homo sapiens

658922

0.0008 - 0.001

NADPH

2 entries

0.04

prostaglandin A1

Rattus norvegicus

390070

0.0618 - 0.135

Z12(13)-epoxyoctadec-Z9-enoic acid

3 entries

0.0466 - 0.1631

Z9(10)-epoxyoctadec-Z12-enoic acid

3 entries

0.0063 - 0.0357

Z9(10)-epoxyoctadecanoic acid

3 entries