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1.14.14.94: leukotriene-B4 20-monooxygenase

This is an abbreviated version!
For detailed information about leukotriene-B4 20-monooxygenase, go to the full flat file.

Word Map on EC 1.14.14.94

Reaction

(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate
+
[reduced NADPH-hemoprotein reductase]
 +
O2
=
(6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate
 +
[oxidized NADPH-hemoprotein reductase]
 +
H2O

Synonyms

CYP4 omega-hydroxylase, CYP4A11, CYP4F11, CYP4F12, CYP4F13, CYP4F14, CYP4F15, CYP4F16, CYP4F17, CYP4F18, CYP4F2, CYP4F3, CYP4F37, CYP4F39, CYP4F3A, CYP4F3B, CYP4F4, CYP4F40, CYP4F8, CYPIVF2, CYPIVF3, cytochrome CYP4F3A, cytochrome P-450 4F18, cytochrome P450 4F2, cytochrome P450 4F3, Cytochrome P450-LTB-omega, EC 1.14.13.30, leukotriene B4 20-hydroxylase, leukotriene B4 omega-1/omega-2 hydroxylase, leukotriene B4 omega-hydroxylase, Leukotriene-B4 20-monooxygenase, leukotriene-B4 omega-hydroxylase, LTB4 20-hydroxylase, LTB4 hydroxylase, LTB4 omega hydroxylase, LTB4 omega-hydroxylase, LTB4OH, More, oxygenase, leukotriene B4 20-mono-, TOH-omega-hydroxylase, vitamin E-omega-hydroxylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.14.94 leukotriene-B4 20-monooxygenase

Cloned

Cloned on EC 1.14.14.94 - leukotriene-B4 20-monooxygenase

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
chromosomal localization 19p
-
CYP4F14, expression in yeast cells
CYP4F3 gene contains 14 exons and 13 introns
-
expression in Escherichia coli
-
expression in Spodoptera frugiperda Sf9 cells using the baculovirus infection system
-
expression in transfected COS-7 cells
-
expression in yeast
-
expression in yeast cells
-
expression in yeast cells, CYP4F3
-
expression of wild-type and CYP4F2 mutant enzymes in Spodoptera frugiperda SF9 insect cell microsomes via the baculovrius transfection system
-
gene Cyp4f18, expression analysis of CYP4F18 in different cell types, recombinant expression of the enzyme in Spodoptera frugiperda Sf9 cell microsomes via baculovirus transfection system
-
tissue-specific expression is regulated by alternative promoter usage and mutually exclusive exon splicing, exon 3 and 4
-
two isoforms of CYP4F3, CYP4F3A expressed in neutrophils and CYP4F3B expressed in fetal and adult liver
-
wild-type and mutant DNA and amino acid sequence determinations, functional nonsynonymous polymorphisms, overview, expression of wild-type and mutant genes in Spodoptera frugiperda Sf9 cells using the baculovirus transfection method