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1.14.14.94: leukotriene-B4 20-monooxygenase

This is an abbreviated version!
For detailed information about leukotriene-B4 20-monooxygenase, go to the full flat file.

Word Map on EC 1.14.14.94

Reaction

(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate
+
[reduced NADPH-hemoprotein reductase]
 +
O2
=
(6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate
 +
[oxidized NADPH-hemoprotein reductase]
 +
H2O

Synonyms

CYP4 omega-hydroxylase, CYP4A11, CYP4F11, CYP4F12, CYP4F13, CYP4F14, CYP4F15, CYP4F16, CYP4F17, CYP4F18, CYP4F2, CYP4F3, CYP4F37, CYP4F39, CYP4F3A, CYP4F3B, CYP4F4, CYP4F40, CYP4F8, CYPIVF2, CYPIVF3, cytochrome CYP4F3A, cytochrome P-450 4F18, cytochrome P450 4F2, cytochrome P450 4F3, Cytochrome P450-LTB-omega, EC 1.14.13.30, leukotriene B4 20-hydroxylase, leukotriene B4 omega-1/omega-2 hydroxylase, leukotriene B4 omega-hydroxylase, Leukotriene-B4 20-monooxygenase, leukotriene-B4 omega-hydroxylase, LTB4 20-hydroxylase, LTB4 hydroxylase, LTB4 omega hydroxylase, LTB4 omega-hydroxylase, LTB4OH, More, oxygenase, leukotriene B4 20-mono-, TOH-omega-hydroxylase, vitamin E-omega-hydroxylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.14.94 leukotriene-B4 20-monooxygenase

Activating Compound

Activating Compound on EC 1.14.14.94 - leukotriene-B4 20-monooxygenase

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
all-trans retinoic acid
-
significantly induces expression of CYP4F3A at both mRNA and protein levels in cultured HL-60 cells
all-trans-retinoic acid
-
after 6 days of retinoid exposure, cutaneous transcripts arising from Cyp4f39 are up-regulated. No changes in transcript abundance for the Cyp4f16, 4f17, and 4f18 genes
Benzene
-
induces CYP4F3 in human blood cells both in vivo and in vitro
lipopolysaccharide
-
upregulates expression and activity of LTB4OH in ex-smokers in a dose-dependent manner, but not in smokers. In vitro smoke exposure of ex-smokers' bronchoalveolar lavage cells abrogates the lipopolysaccharide-induced up-regulation of LTB4OH mRNA expression, thus tobacco smoke alters bronchoalveolar lavage cell LTB4OH mRNA expression in response to lipopolysaccharide exposure
phenol
-
significantly induces expression of CYP4F3A at both mRNA and protein levels in cultured and differentiated HL-60 cells, in the proerythroid cell line K-562, and ex vivo in human neutrophils
additional information
-