1.14.14.114: amorpha-4,11-diene 12-monooxygenase

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For detailed information about amorpha-4,11-diene 12-monooxygenase, go to the full flat file.

Word Map on EC 1.14.14.114

1.14.14.114

annua

artemisia

malaria

artemisinic

trichomes

sesquiterpene

dihydroartemisinic

lactone

glandular

anti-malarial

trichome-specific

farnesyl

endoperoxide

sesquiterpenoids

artemisinin-based

one-hybrid

arteannuin

amorphadiene

asteraceae

synthesis

t-shaped

jasmonate-responsive

12-hydroxylase

Reaction

+ 3 O2 + 3 [reduced NADPH-hemoprotein reductase] =

+ 3 [oxidized NADPH-hemoprotein reductase] + 4 H2O

Synonyms

ALDH1, amorpha-4,11-diene C-12 oxidase, amorpha-4,11-diene monooxygenase, CYP71AV1, cytochrome P450 monooxygenase 71 AV1, EC 1.14.13.158

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

1.14.14.114 amorpha-4,11-diene 12-monooxygenase

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Results	in table
6	AA Sequence
3	Application
8	Cloned(Commentary)
17	Cofactor
3	Expression
17	General Information
2	kcat/KM [mM/s]
2	KM Value [mM]
1	Molecular Weight [Da]
21	Natural Substrates/ Products (Substrates)
15	Organism
2	Pathway
3	pH Optimum
2	Protein Variants
4	Reaction
14	Reference
20	Source Tissue
36	Substrates and Products (Substrate)
1	Subunits
18	Synonyms
1	Systematic Name
2	Turnover Number [1/s]

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Reference on EC 1.14.14.114 - amorpha-4,11-diene 12-monooxygenase

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706125

Olsson, M.E.; Olofsson, L.M.; Lindahl, A.L.; Lundgren, A.; Brodelius, M.; Brodelius, P.E.

Localization of enzymes of artemisinin biosynthesis to the apical cells of glandular secretory trichomes of Artemisia annua L

Phytochemistry

1123-1128

2009

Artemisia annua

19664791

716656

Alejos-Gonzalez, F.; Qu, G.; Zhou, L.L.; Saravitz, C.H.; Shurtleff, J.L.; Xie, D.Y.

Characterization of development and artemisinin biosynthesis in self-pollinated Artemisia annua plants

Planta

234

685-697

2011

Artemisia annua

21614500

717445

Teoh, K.; Polichuk, D.; Reed, D.; Covello, P.

Molecular cloning of an aldehyde dehydrogenase implicated in artemisinin biosynthesis in Artemisia annua

Botany

635-642

2009

Artemisia annua, Artemisia annua (C5I9X1)

717601

Teoh, K.H.; Polichuk, D.R.; Reed, D.W.; Nowak, G.; Covello, P.S.

Artemisia annua L. (Asteraceae) trichome-specific cDNAs reveal CYP71AV1, a cytochrome P450 with a key role in the biosynthesis of the antimalarial sesquiterpene lactone artemisinin

FEBS Lett.

580

1411-1416

2006

Artemisia annua (Q1PS23), Artemisia annua

16458889

718205

Zhang, Y.; Nowak, G.; Reed, D.W.; Covello, P.S.

The production of artemisinin precursors in tobacco

Plant Biotechnol. J.

445-454

2011

Artemisia annua

20723135

745821

Chen, X.; Zhang, C.; Too, H.

Multienzyme biosynthesis of dihydroartemisinic acid

Molecules

1422-1433

2017

Artemisia annua (Q1PS23)

28846664

745905

Chen, M.; Yan, T.; Shen, Q.; Lu, X.; Pan, Q.; Huang, Y.; Tang, Y.; Fu, X.; Liu, M.; Jiang, W.; Lv, Z.; Shi, P.; Ma, Y.; Hao, X.; Zhang, L.; Li, L.; Tang, K.

Glandular trichome-specific WRKY 1 promotes artemisinin biosynthesis in Artemisia annua

New Phytol.

214

304-316

2017

Artemisia annua (Q1PS23), Artemisia annua

28001315

746035

Ji, Y.; Xiao, J.; Shen, Y.; Ma, D.; Li, Z.; Pu, G.; Li, X.; Huang, L.; Liu, B.; Ye, H.; Wang, H.

Cloning and characterization of AabHLH1, a bHLH transcription factor that positively regulates artemisinin biosynthesis in Artemisia annua

Plant Cell Physiol.

1592-1604

2014

Artemisia annua (Q1PS23), Artemisia annua

24969234

746043

Muangphrom, P.; Seki, H.; Suzuki, M.; Komori, A.; Nishiwaki, M.; Mikawa, R.; Fukushima, E.O.; Muranaka, T.

Functional analysis of amorpha-4,11-diene synthase (ADS) homologs from non-artemisinin-producing artemisia species the discovery of novel koidzumiol and (+)-alpha-bisabolol synthases

Plant Cell Physiol.

1678-1688

2016

Artemisia kurramensis, Artemisia absinthium (K7ZPJ9), Artemisia absinthium, Artemisia afra (K7ZR99), Artemisia annua (Q1PS23), Artemisia annua

27273626

746069

Zheng, L.; Tian, H.; Yuan, Y.; Wang, J.

The influence of endophytic Penicillium oxalicum B4 on growth and artemisinin biosynthesis of in vitro propagated plantlets of Artemisia annua L.

Plant Growth Regul.

93-102

2016

Artemisia annua (Q1PS23)

746309

Czechowski, T.; Larson, T.R.; Catania, T.M.; Harvey, D.; Brown, G.D.; Graham, I.A.

Artemisia annua mutant impaired in artemisinin synthesis demonstrates importance of nonenzymatic conversion in terpenoid metabolism

Proc. Natl. Acad. Sci. USA

113

15150-15155

2016

Artemisia annua (Q1PS23), Artemisia annua

27930305