1.14.14.114: amorpha-4,11-diene 12-monooxygenase

This is an abbreviated version!
For detailed information about amorpha-4,11-diene 12-monooxygenase, go to the full flat file.

+ 3 O2 + 3 [reduced NADPH-hemoprotein reductase] =

+ 3 [oxidized NADPH-hemoprotein reductase] + 4 H2O

ALDH1, amorpha-4,11-diene C-12 oxidase, amorpha-4,11-diene monooxygenase, CYP71AV1, cytochrome P450 monooxygenase 71 AV1, EC 1.14.13.158

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Results	in table
6	AA Sequence
3	Application
8	Cloned(Commentary)
17	Cofactor
3	Expression
17	General Information
2	kcat/KM [mM/s]
2	KM Value [mM]
1	Molecular Weight [Da]
21	Natural Substrates/ Products (Substrates)
15	Organism
2	Pathway
3	pH Optimum
2	Protein Variants
4	Reaction
14	Reference
20	Source Tissue
36	Substrates and Products (Substrate)
1	Subunits
18	Synonyms
1	Systematic Name
2	Turnover Number [1/s]

Reaction on EC 1.14.14.114 - amorpha-4,11-diene 12-monooxygenase

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amorpha-4,11-diene + 3 O2 + 3 [reduced NADPH-hemoprotein reductase] = artemisinate + 3 [oxidized NADPH-hemoprotein reductase] + 4 H2O

overall reaction

amorpha-4,11-diene + O2 + [reduced NADPH-hemoprotein reductase] = artemisinic alcohol + [oxidized NADPH-hemoprotein reductase] + H2O

(1a)

artemisinic alcohol + O2 + [reduced NADPH-hemoprotein reductase] = artemisinic aldehyde + [oxidized NADPH-hemoprotein reductase] + 2 H2O

(1b)

artemisinic aldehyde + O2 + [reduced NADPH-hemoprotein reductase] = artemisinate + [oxidized NADPH-hemoprotein reductase] + H2O

(1c)