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1.14.14.114: amorpha-4,11-diene 12-monooxygenase

This is an abbreviated version!
For detailed information about amorpha-4,11-diene 12-monooxygenase, go to the full flat file.

Word Map on EC 1.14.14.114

Reaction

amorpha-4,11-diene
+ 3 O2 + 3 [reduced NADPH-hemoprotein reductase] =
artemisinate
+ 3 [oxidized NADPH-hemoprotein reductase] + 4 H2O

Synonyms

ALDH1, amorpha-4,11-diene C-12 oxidase, amorpha-4,11-diene monooxygenase, CYP71AV1, cytochrome P450 monooxygenase 71 AV1, EC 1.14.13.158

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.14.114 amorpha-4,11-diene 12-monooxygenase

Natural Substrates Products

Natural Substrates Products on EC 1.14.14.114 - amorpha-4,11-diene 12-monooxygenase

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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
amorpha-4,11-diene + 3 O2 + [reduced NADPH-hemoprotein reductase]
artemisinate + [oxidized NADPH-hemoprotein reductase] + 4 H2O
show the reaction diagram
amorpha-4,11-diene + O2 + [reduced NADPH-hemoprotein reductase]
artemisinic alcohol + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
artemisinic alcohol + O2 + [reduced NADPH-hemoprotein reductase]
artemisinic aldehyde + [oxidized NADPH-hemoprotein reductase] + 2 H2O
show the reaction diagram
artemisinic aldehyde + O2 + [reduced NADPH-hemoprotein reductase]
artemisinate + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram