2.1.1.B130: [histone H3]-N-methyllysine9 N-methyltransferase
This is an abbreviated version!
For detailed information about [histone H3]-N-methyllysine9 N-methyltransferase, go to the full flat file.
Reaction
+ 2 S-adenosyl-L-methionine = + 2 S-adenosyl-L-homocysteine
Synonyms
SU(VAR)3-9 RELATED4, SUVR4
ECTree
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Substrates Products
Substrates Products on EC 2.1.1.B130 - [histone H3]-N-methyllysine9 N-methyltransferase
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REACTION DIAGRAM
N6,N6-dimethyl-L-lysyl9-[histone H3] + S-adenosyl-L-methionine
N6,N6,N6-trimethyl-L-lysyl9-[histone H3] + S-adenosyl-L-homocysteine
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N6-methyl-L-lysyl9-[histone H3 peptide 1-20] + S-adenosyl-L-methionine
N6,N6-dimethyl-L-lysyl9-[histone H3 peptide 1-20] + S-adenosyl-L-homocysteine
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N6-methyl-L-lysyl9-[histone H3 peptide 5-11] + S-adenosyl-L-methionine
N6,N6-dimethyl-L-lysyl9-[histone H3 peptide 5-11] + S-adenosyl-L-homocysteine
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N6-methyl-L-lysyl9-[histone H3] + 2 S-adenosyl-L-methionine
N6,N6,N6-trimethyl-L-lysyl9-[histone H3] + 2 S-adenosyl-L-homocysteine
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N6-methyl-L-lysyl9-[histone H3] + S-adenosyl-L-methionine
N6,N6-dimethyl-L-lysyl9-[histone H3] + S-adenosyl-L-homocysteine
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in the absence of ubiquitin, SUVR4 converts 40.9% of the H3K9me1 peptide to H3K9me2, while 0% is converted to H3K9me3. In the presence of ubiquitin, 90.2% of the H3K9me1 peptide is converted to H3K9me2 while 3.5% is converted to H3K9me3. When H3K9me2 peptides are used as substrate, there is no conversion to H3K9me3 above background level in the absence of ubiquitin. When ubiquitin is present together with SUVR4, a 16.4% conversion from H3K9me2 to H3K9me3 is found
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additional information
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SUVR4 protein shows very low histone methyltransferase activity against the unmethylated histone H3 1-20 peptide. SUVR4 is also unable to methylate H3 1-20 peptides monomethylated at K4 or dimethylated at K9. SUVR4 is able to methylate histone H3 peptides of variable size when monomethylated at K9, but not when monomethylated at K4 or K27 or dimethylated on K9
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