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2.1.1.B130: [histone H3]-N-methyllysine9 N-methyltransferase

This is an abbreviated version!
For detailed information about [histone H3]-N-methyllysine9 N-methyltransferase, go to the full flat file.

Reaction

N6-methyl-L-lysyl9-[histone H3]
+ 2 S-adenosyl-L-methionine =
N6,N6,N6-trimethyl-L-lysyl9-[histone H3]
+ 2 S-adenosyl-L-homocysteine

Synonyms

SU(VAR)3-9 RELATED4, SUVR4

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.B130 [histone H3]-N-methyllysine9 N-methyltransferase

Engineering

Engineering on EC 2.1.1.B130 - [histone H3]-N-methyllysine9 N-methyltransferase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
A32E
mutation in WIYLD domain, reduces the binding affinity to ubiquitin by 37%. The mutation disrupts the entire domain structure
W405F
loss of catalytic activity
W405Y
loss of catalytic activity
W61R
mutation in WIYLD domain, reduces the binding affinity to ubiquitin by 75%