2.1.1.B130: [histone H3]-N-methyllysine9 N-methyltransferase
This is an abbreviated version!
For detailed information about [histone H3]-N-methyllysine9 N-methyltransferase, go to the full flat file.
Reaction
+ 2 S-adenosyl-L-methionine = + 2 S-adenosyl-L-homocysteine
Synonyms
SU(VAR)3-9 RELATED4, SUVR4
ECTree
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General Information
General Information on EC 2.1.1.B130 - [histone H3]-N-methyllysine9 N-methyltransferase
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physiological function
SUVR4 binds histone H3 irrespective of the methylation status of lysine 9
physiological function
the N-terminal WIYLD domain of the SUVR4 HKMTase binds ubiquitin and the SUVR4 product specificity shifts from di- to trimethylation in the presence of free ubiquitin, enabling conversion of H3K9me1 to H3K9me3 in vitro. SUVR4 in vivo specifically converts H3K9me1 to H3K9me3 at transposons and pseudogenes and has a locus-specific repressive effect on the expression of such elements. This repression involves both DNA methylation-dependent and -independent mechanisms