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1.14.14.176: taxadiene 5alpha-hydroxylase

This is an abbreviated version!
For detailed information about taxadiene 5alpha-hydroxylase, go to the full flat file.

Word Map on EC 1.14.14.176

Reaction

taxa-4,11-diene
+
[reduced NADPH-hemoprotein reductase]
 +
O2
=
taxa-4(20),11-dien-5alpha-ol
 +
[oxidized NADPH-hemoprotein reductase]
 +
H2O

Synonyms

5alphaCYP, CYP725A4, EC 1.14.99.37, oxygenase, taxadiene 5-mono-, taxa-4(5),11(12)-diene 5-hydroxylase, taxa-4(5),11(12)-diene 5alpha-hydroxylase, taxadien-5alpha-hydroxylase, taxadiene 5-hydroxylase, taxadiene 5-monooxygenase, taxadiene synthase, taxadiene-5alpha-hydroxylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.14.176 taxadiene 5alpha-hydroxylase

Systematic Name

Systematic Name on EC 1.14.14.176 - taxadiene 5alpha-hydroxylase

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SYSTEMATIC NAME
IUBMB Comments
taxa-4,11-diene,[reduced NADPH-hemoprotein reductase]:oxygen oxidoreductase (5alpha-hydroxylating)
This microsomal cytochrome-P-450 (heme-thiolate) enzyme is involved in the biosynthesis of the diterpenoid antineoplastic drug taxol (paclitaxel). The reaction includes rearrangement of the 4(5)-double bond to a 4(20)-double bond, possibly through allylic oxidation.