1.14.14.176: taxadiene 5alpha-hydroxylase
This is an abbreviated version!
For detailed information about taxadiene 5alpha-hydroxylase, go to the full flat file.
Word Map on EC 1.14.14.176
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1.14.14.176
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taxol
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paclitaxel
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medicine
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taxane
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synthesis
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bottleneck
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oxygenases
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nanodiscs
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drug development
- 1.14.14.176
- taxol
- paclitaxel
- medicine
-
taxane
- synthesis
-
bottleneck
- oxygenases
-
nanodiscs
- drug development
Reaction
Synonyms
5alphaCYP, CYP725A4, EC 1.14.99.37, oxygenase, taxadiene 5-mono-, taxa-4(5),11(12)-diene 5-hydroxylase, taxa-4(5),11(12)-diene 5alpha-hydroxylase, taxadien-5alpha-hydroxylase, taxadiene 5-hydroxylase, taxadiene 5-monooxygenase, taxadiene synthase, taxadiene-5alpha-hydroxylase
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Reference on EC 1.14.14.176 - taxadiene 5alpha-hydroxylase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Wheeler, A.L.; Long, R.M.; Ketchum, R.E.B.; Rithner, C.D.; Williams, R.M.; Croteau, R.
Taxol biosynthesis: differential transformations of taxadien-5alpha-ol and its acetate ester by cytochrome P450 hydroxylases from Taxus suspension cells
Arch. Biochem. Biophys.
390
265-278
2001
Taxus cuspidata
Hefner, J.; Rubenstein, S.M.; Ketchum, R.E.B.; Gibson, D.M.; Williams, R.M.; Croteau, R.
Cytochrome P450-catalyzed hydroxylation of taxa-4(5),11(12)-diene to taxa-4(20),11(12)-dien-5alpha-ol: the first oxygenation step in taxol biosynthesis
Chem. Biol.
3
479-489
1996
Taxus brevifolia, Taxus cuspidata
Walker, K.; Croteau, R.
Taxol biosynthetic genes
Phytochemistry
58
1-7
2001
Taxus brevifolia, Taxus cuspidata
Jennewein, S.; Long, R.M.; Williams, R.M.; Croteau, R.
Cytochrome p450 taxadiene 5alpha-hydroxylase, a mechanistically unusual monooxygenase catalyzing the first oxygenation step of taxol biosynthesis
Chem. Biol.
11
379-387
2004
Taxus cuspidata (Q6WG30)
Rontein, D.; Onillon, S.; Herbette, G.; Lesot, A.; Werck-Reichhart, D.; Sallaud, C.; Tissier, A.
CYP725A4 from yew catalyzes complex structural rearrangement of taxa-4(5),11(12)-diene into the yclic ether 5(12)-oxa-3(11)-cyclotaxane
J. Biol. Chem.
283
6067-6075
2008
Taxus cuspidata (Q6WG30)
Biggs, B.W.; Rouck, J.E.; Kambalyal, A.; Arnold, W.; Lim, C.G.; De Mey, M.; ONeil-Johnson, M.; Starks, C.M.; Das, A.; Ajikumar, P.K.
Orthogonal assays clarify the oxidative biochemistry of taxol P450 CYP725A4
ACS Chem. Biol.
11
1445-1451
2016
Taxus brevifolia
Edgar, S.; Zhou, K.; Qiao, K.; King, J.R.; Simpson, J.H.; Stephanopoulos, G.
Mechanistic insights into taxadiene epoxidation by taxadiene-5alpha-hydroxylase
ACS Chem. Biol.
11
460-469
2016
Taxus cuspidata (Q6WG30)
Edgar, S.; Li, F.S.; Qiao, K.; Weng, J.K.; Stephanopoulos, G.
Engineering of taxadiene synthase for improved selectivity and yield of a key taxol biosynthetic intermediate
ACS Synth. Biol.
6
201-205
2017
Taxus sp.
Sagwan-Barkdoll, L.; Anterola, A.M.
Taxadiene-5alpha-ol is a minor product of CYP725A4 when expressed in Escherichia coli
Biotechnol. Appl. Biochem.
65
294-305
2018
Taxus cuspidata (Q6WG30), Taxus cuspidata
Rouck, J.E.; Biggs, B.W.; Kambalyal, A.; Arnold, W.R.; De Mey, M.; Ajikumar, P.K.; Das, A.
Heterologous expression and characterization of plant taxadiene-5alpha-hydroxylase (CYP725A4) in Escherichia coli
Protein Expr. Purif.
132
60-67
2017
Taxus cuspidata (Q6WG30)
Walls, L.E.; Malci, K.; Nowrouzi, B.; Li, R.; d'Espaux, L.; Wong, J.; Dennis, J.A.; Semiao, A.J.C.; Wallace, S.; Martinez, J.L.; Keasling, J.D.; Rios-Solis, L.
Optimising the biosynthesis of oxygenated and acetylated taxol precursors in Saccharomyces cerevisiae using advanced bioprocessing strategies
Biotechnol. Bioeng.
118
279-293
2020
Taxus cuspidata (Q6WG30)
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