1.14.14.176: taxadiene 5alpha-hydroxylase

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For detailed information about taxadiene 5alpha-hydroxylase, go to the full flat file.

Word Map on EC 1.14.14.176

1.14.14.176

taxol

paclitaxel

medicine

taxane

synthesis

bottleneck

oxygenases

nanodiscs

drug development

Reaction

Synonyms

5alphaCYP, CYP725A4, EC 1.14.99.37, oxygenase, taxadiene 5-mono-, taxa-4(5),11(12)-diene 5-hydroxylase, taxa-4(5),11(12)-diene 5alpha-hydroxylase, taxadien-5alpha-hydroxylase, taxadiene 5-hydroxylase, taxadiene 5-monooxygenase, taxadiene synthase, taxadiene-5alpha-hydroxylase

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

1.14.14.176 taxadiene 5alpha-hydroxylase

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Results	in table
4	Activating Compound
7	AA Sequence
7	Application
1	CAS Registry Number
6	Cloned(Commentary)
3	Cofactor
8	Inhibitors
5	KM Value [mM]
5	Localization
14	Natural Substrates/ Products (Substrates)
14	Organism
6	Pathway
2	pH Optimum
2	Purification (Commentary)
5	Reaction
4	Reaction Type
14	Reference
5	Source Tissue
19	Substrates and Products (Substrate)
19	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

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Reaction on EC 1.14.14.176 - taxadiene 5alpha-hydroxylase

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taxa-4,11-diene + [reduced NADPH-hemoprotein reductase] + O2 = taxa-4(20),11-dien-5alpha-ol + [oxidized NADPH-hemoprotein reductase] + H2O

5 entries