1.14.14.125: monacolin L hydroxylase

This is an abbreviated version!
For detailed information about monacolin L hydroxylase, go to the full flat file.

Reaction

Synonyms

EC 1.14.13.198, LovA

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

                1.14.14.125 monacolin L hydroxylase

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Results	in table
3	AA Sequence
1	Cloned(Commentary)
1	Cofactor
1	KM Value [mM]
1	Natural Substrates/ Products (Substrates)
1	Organism
4	Pathway
1	Reaction
1	Reference
2	Substrates and Products (Substrate)
2	Synonyms
1	Systematic Name

Substrates Products

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Substrates Products on EC 1.14.14.125 - monacolin L hydroxylase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

monacolin L acid + [reduced NADPH-hemoprotein reductase] + O2

monacolin J acid + [oxidized NADPH-hemoprotein reductase] + H2O

2 entries

monacolin L acid + [reduced NADPH-hemoprotein reductase] + O2

monacolin J acid + [oxidized NADPH-hemoprotein reductase] + H2O

Aspergillus terreus

Q9Y7C8

monacolin L acid i.e. (3R,5R)-7-[(1S,2S,6R,8aR)-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid. The enzyme also catalyses the reaction of EC 1.14.13.197, dihydromonacolin L hydroxylase. The enzyme is involved in the biosynthesis of lovastatin

727670

monacolin J acid i.e. (3R,5R)-7-[(1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid

-

?

monacolin L acid + [reduced NADPH-hemoprotein reductase] + O2

monacolin J acid + [oxidized NADPH-hemoprotein reductase] + H2O

Aspergillus terreus

Q9Y7C8

monacolin L acid i.e. (3R,5R)-7-[(1S,2S,6R,8aR)-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid. The enzyme also catalyses the reaction of EC 1.14.13.197, dihydromonacolin L hydroxylase

727670

monacolin J acid i.e. (3R,5R)-7-[(1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid

-

?