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1.14.14.125: monacolin L hydroxylase

This is an abbreviated version!
For detailed information about monacolin L hydroxylase, go to the full flat file.

Reaction

monacolin L acid
+
O2
+
[reduced NADPH-hemoprotein reductase]
=
monacolin J acid
+
[oxidized NADPH-hemoprotein reductase]
+
H2O

Synonyms

EC 1.14.13.198, LovA

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.14.125 monacolin L hydroxylase

Reference

Reference on EC 1.14.14.125 - monacolin L hydroxylase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Barriuso, J.; Nguyen, D.T.; Li, J.W.; Roberts, J.N.; MacNevin, G.; Chaytor, J.L.; Marcus, S.L.; Vederas, J.C.; Ro, D.K.
Double oxidation of the cyclic nonaketide dihydromonacolin L to monacolin J by a single cytochrome P450 monooxygenase, LovA
J. Am. Chem. Soc.
133
8078-8081
2011
Aspergillus terreus (Q9Y7C8)
Manually annotated by BRENDA team