2.3.1.82: aminoglycoside 6'-N-acetyltransferase

This is an abbreviated version!
For detailed information about aminoglycoside 6'-N-acetyltransferase, go to the full flat file.

Word Map on EC 2.3.1.82

2.3.1.82

quinolone

plasmid-mediated

ciprofloxacin

amikacin

extended-spectrum

fluoroquinolones

gyras

esbls

integrons

aac6\'-ib-cr

tobramycin

aac6\'-ib

blactx-m-15

esbl-producing

aminoglycoside-modifying

blatem-1

blactx-m

blashv

blaoxa-1

netilmicin

oqxab

resistance-determining

fluoroquinolone-resistant

ciprofloxacin-resistant

quinolone-resistant

carbapenemase

aminoglycoside-resistant

ctx-m-3

blacmy-2

isecp1

aph3\'-ia

qrdrs

blakpc-2

carbapenemase-producing

nonduplicate

sisomicin

blashv-12

ctx-m-15-producing

esbl-positive

co-harbored

dfra12

arbekacin

inchi2

co-harbouring

ctx-m-producing

analysis

ndm-1-producing

cephalosporin-resistant

medicine

Reaction

Synonyms

6'-acetyltransferase-Im, 6'-N-acetyltransferase type Ib, AAC, aac(3)-Ib/aac(6')-Ib, AAC(3)-Ib/AAC(6')-Ib', AAC(6'), AAC(6')-I, AAC(6')-Iaf, AAC(6')-IaI, AAC(6')-Iaj, AAC(6')-Ian, AAC(6')-Ib, AAC(6')-Ib-cr, AAC(6')-Ie, AAC(6')-Ie/APH(2")-Ia, AAC(6')-Ie/APH(2'')-Ia, AAC(6')-Ie/APH(2')-Ia, AAC(6')-Ig, AAC(6')-Ih, AAC(6')-Ii, AAC(6')-Im, AAC(6')-Isa, AAC(6')-Iy, AAC(6')-Iz acetyltransferase, AAC(6)-Iak, aac(6)-Ib, AAC3-I, aacA-aphD, acetyltransferase, aminoglycoside 6'-N-, acetyltransferase, kanamycin, acetyltransferase-6'-aminoglycoside phosphotransferase-2", aminoglycoside (3) acetyltransferase AAC(3)-Ia, aminoglycoside 3-N-acetyltransferase/aminoglycoside 6'-N-acetyltransferase fusion protein, aminoglycoside 6'-acetyltransferase-Ie, aminoglycoside 6'-N-acetyltransferase, aminoglycoside 6'-N-acetyltransferase Ib, aminoglycoside 6'-N-acetyltransferase type Ib, aminoglycoside 6'-N-acetyltransferase type Ii, aminoglycoside 6-N-acetyltransferase, aminoglycoside acetyltransferase, aminoglycoside acetyltransferase eis, aminoglycoside acetyltransferase(6')-Ie/aminoglycoside phosphotransferase(2')-Ia, aminoglycoside N(6')-acetyltransferase type 1, aminoglycoside N-6'-acetyltransferase, aminoglycoside N-6'-acetyltransferase Ii, aminoglycoside N-acetyltransferase, aminoglycoside-6'-acetyltransferase, aminoglycoside-6'-N-acetyltransferase, aminoglycoside-6-N-acetyltransferase, ANT(3'')-Ii/AAC(6')-IId, EC 2.3.1.55, meta-AAC0020

ECTree

2 Transferases

2.3 Acyltransferases

2.3.1 Transferring groups other than aminoacyl groups

2.3.1.82 aminoglycoside 6'-N-acetyltransferase

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Results	in table
2538	AA Sequence
8	Application
1	CAS Registry Number
22	Cloned(Commentary)
5	Cofactor
11	Crystallization (Commentary)
1	Expression
7	General Information
3	General Stability
13	IC50 Value
85	Inhibitors
65	kcat/KM [mM/s]
78	Ki Value [mM]
230	KM Value [mM]
1	Localization
1	Metals/Ions
10	Molecular Weight [Da]
40	Natural Substrates/ Products (Substrates)
114	Organism
24	PDB ID
15	pH Optimum
1	pH Range
1	Posttranslational Modification
50	Protein Variants
16	Purification (Commentary)
2	Reaction
6	Reaction Type
93	Reference
2	Specific Activity [micromol/min/mg]
2	Storage Stability
361	Substrates and Products (Substrate)
10	Subunits
97	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
3	Temperature Stability [°C]
186	Turnover Number [1/s]

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Reference on EC 2.3.1.82 - aminoglycoside 6'-N-acetyltransferase

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487272

Benveniste, R.; Davies, J.

Aminoglycoside antibiotic-inactivating enzymes in actinomycetes similar to those present in clinical isolates of antibiotic-resistant bacteria

Proc. Natl. Acad. Sci. USA

2276-2280

1973

Streptomyces kanamyceticus

4209515

636898

Benveniste, R.; Davies, J.

Enzymatic acetylation of aminoglycoside antibiotics by Escherichia coli carrying an R factor

Biochemistry

1787-1796

1971

Escherichia coli

4935296

636899

Le Goffic, F.; Martel, A.

Resistance to aminosides induced by an isoenzyme, kanamycin acetyltransferase

Biochimie

893-897

1974

Escherichia coli, Moraxella sp., Escherichia coli CS2R2

4614862

636901

Meyer, J.F.; Wiedemann, B.

Characterization of aminoglycoside 6-N-acetyltransferases [AAC(6)] from gram-negative bacteria and Streptomyces kanamyceticus

J. Antimicrob. Chemother.

271-282

1985

Escherichia coli, Pseudomonas aeruginosa, Serratia marcescens, Streptomyces kanamyceticus, Escherichia coli NR79, Serratia marcescens VU12944/77

3997703

636902

Martel, A.; Masson, M.; Moreau, N.; Le Goffic, F.

Kinetic studies of aminoglycoside acetyltransferase and phosphotransferase from Staphylococcus aureus RPAL. Relationship between the two activities

Eur. J. Biochem.

133

515-521

1983

Staphylococcus aureus

6305650

636903

Rather, P.N.; Munayyer, H.; Mann, P.A.; Hare, R.S.; Miller, G.H.; Shaw, K.J.

Genetic analysis of bacterial acetyltransferases: identification of amino acids determining the specificities of the aminoglycoside 6-N-acetyltransferase Ib and IIa proteins

J. Bacteriol.

174

3196-3203

1992

Escherichia coli

1577689

636904

Wybenga-Groot, L.E.; Draker, K.a.; Wright, G.D.; Berghuis, A.M.

Crystal structure of an aminoglycoside 6'-N-acetyltransferase: defining the GCN5-related N-acetyltransferase superfamily fold

Structure

497-507

1999

Enterococcus faecium (Q47764)

10378269

636905

Culebras, E.; Martinez, J.L.; Baquero, F.; Perez-Diaz, J.C.

pH Modulation of aminoglycoside resistance in Staphylococcus epidermidis harboring 6'-N-aminoglycoside acetyltransferase

J. Antimicrob. Chemother.

881-889

1996

Staphylococcus epidermidis, Staphylococcus epidermidis RYC 13036

8737138

636906

Lambert, T.; Ploy, M.C.; Courvalin, P.

A spontaneous point mutation in the aac(6')-Ib� gene results in altered substrate specificity of aminoglycoside 6'-N-acetyltransferase of a Pseudomonas fluorescens strain

FEMS Microbiol. Lett.

115

297-304

1994

Pseudomonas fluorescens, Pseudomonas fluorescens BM2687

8138142

636907

Casin, I.; Bordon, F.; Bertin, P.; Coutrot, A.; Podglajen, I.; Brasseur, R.; Collatz, E.

Aminoglycoside 6'-N-acetyltransferase variants of the Ib type with altered substrate profile in clinical isolates of Enterobacter cloacae and Citrobacter freundii

Antimicrob. Agents Chemother.

209-215

1998

Enterobacter cloacae, Citrobacter freundii, Enterobacter cloacae EC 1562, Citrobacter freundii CFr564

9527761

636908

Zhu, C.B.; Sunada, A.; Ishikawa, J.; Ikeda, Y.; Kondo, S.; Hotta, K.

Role of aminoglycoside 6'-acetyltransferase in a novel multiple aminoglycoside resistance of an actinomycete strain No. 8: inactivation of aminoglycosides with 6'-amino group except arbekacin and neomycin

J. Antibiot.

889-894

1999

Actinomyces sp., Actinomyces sp. 8

10604758

636909

Chavideh, R.; Sholly, S.; Panaite, D.; Tolmasky, M.E.

Effects of F171 mutations in the 6'-N-acetyltransferase type Ib [AAC(6')-Ib] enzyme on susceptibility to aminoglycosides

Antimicrob. Agents Chemother.

2811-2812

1999

Klebsiella pneumoniae

10543772

636910

Wright, G.D.; Ladak, P.

Overexpression and characterization of the chromosomal aminoglycoside 6'-N-acetyltransferase from Enterococcus faecium

Antimicrob. Agents Chemother.

956-960

1997

Enterococcus faecium

9145851

636911

Panaite, D.M.; Tolmasky, M.E.

Characterization of mutants of the 6'-N-acetyltransferase encoded by the multiresistance transposon Tn1331: effect of Phe171-to-Leu171 and Tyr80-to-Cys80 substitutions

Plasmid

123-133

1998

Klebsiella pneumoniae

9514709

636912

Hegde, S.S.; Dam, T.K.; Brewer, C.F.; Blanchard, J.S.

Thermodynamics of aminoglycoside and acyl-Coenzyme A binding to the Salmonella enterica AAC(6')-Iy aminoglycoside N-acetyltransferase

Biochemistry

7519-7527

2002

Salmonella enterica

12044186

636913

Magnet, S.; Lambert, T.; Courvalin, P.; Blanchard, J.S.

Kinetic and mutagenic characterization of the chromosomally encoded Salmonella enterica AAC(6')-Iy aminoglycoside N-acetyltransferase

Biochemistry

3700-3709

2001

Salmonella enterica

11297438

636914

Shmara, A.; Weinsetel, N.; Dery, K.J.; Chavideh, R.; Tolmasky, M.E.

Systematic analysis of a conserved region of the aminoglycoside 6'-N-acetyltransferase type Ib

Antimicrob. Agents Chemother.

3287-3292

2001

Klebsiella pneumoniae (Q93TA5), Klebsiella pneumoniae (Q93TA6), Klebsiella pneumoniae (Q93TA7), Klebsiella pneumoniae (Q93TA8), Klebsiella pneumoniae (Q93TA9), Klebsiella pneumoniae (Q93TB0), Klebsiella pneumoniae (Q93TB1), Klebsiella pneumoniae (Q93TB2), Klebsiella pneumoniae (Q93TB3), Klebsiella pneumoniae (Q93TB4), Klebsiella pneumoniae (Q93TB5), Klebsiella pneumoniae (Q93TB6), Klebsiella pneumoniae (Q93TB7), Klebsiella pneumoniae (Q93TB8), Klebsiella pneumoniae (Q93TB9), Klebsiella pneumoniae (Q93TC0), Klebsiella pneumoniae (Q93TC1), Klebsiella pneumoniae (Q93TC2), Klebsiella pneumoniae (Q93TC3)

11709299

636915

Nobuta K.; Tolmasky M.E.; Crosa L.M.; Crosa J.H.

Sequencing and expression of the 6'-N-acetyltransferase gene of transposon Tn1331 from Klebsiella pneumoniae

J. Bacteriol.

170

3769-3773

1988

Klebsiella pneumoniae (P19650)

2841303

636916

Tolmasky M.E.

Sequencing and expression of aadA, bla, and tnpR from the multiresistance transposon Tn1331

Plasmid

218-226

1990

Klebsiella pneumoniae (P19650)

1963948

636917

Tenover F.C.; Filpula D.; Phillips K.L.; Plorde J.J.

Cloning and sequencing of a gene encoding an aminoglycoside 6'-N-acetyltransferase from an R factor of Citrobacter diversus

J. Bacteriol.

170

471-473

1988

Citrobacter koseri (P10051), Citrobacter koseri

2826403

636918

Bunny K.L.; Hall R.M.; Stokes H.W.

New mobile gene cassettes containing an aminoglycoside resistance gene, aacA7, and a chloramphenicol resistance gene, catB3, in an integron in pBWH301

Antimicrob. Agents Chemother.

686-693

1995

Klebsiella aerogenes (P50858)

7793874

636919

Van Nhieu G.T.; Collatz E.

Primary structure of an aminoglycoside 6'-N-acetyltransferase AAC(6')-4, fused in vivo with the signal peptide of the Tn3-encoded beta-lactamase

J. Bacteriol.

169

5708-5714

1987

Serratia marcescens (P20092)

2824444

657553

Magnet, S.; Smith, T.A.; Zheng, R.; Nordmann, P.; Blanchard, J.S.

Aminoglycoside resistance resulting from tight drug binding to an altered aminoglycoside acetyltransferase

Antimicrob. Agents Chemother.

1577-1583

2003

Pseudomonas aeruginosa

12709325

657554

Dery, K.J.; Soballe, B.; Witherspoon, M.S.; Bui, D.; Koch, R.; Sherratt, D.J.; Tolmasky, M.E.

The aminoglycoside 6'-N-acetyltransferase type Ib encoded by Tn1331 is evenly distributed within the cell's cytoplasm

Antimicrob. Agents Chemother.

2897-2902

2003

Escherichia coli

12936992

657555

Casin, I.; Hanau-Bercot, B.; Podglajen, I.; Vahaboglu, H.; Collatz, E.

Salmonella enterica serovar typhimurium bla(PER-1)-carrying plasmid pSTI1 encodes an extended-spectrum aminoglycoside 6'-N-acetyltransferase of type Ib

Antimicrob. Agents Chemother.

697-703

2003

Salmonella enterica

12543680

657563

Pourreza, A.; Witherspoon, M.; Fox, J.; Newmark, J.; Bui, D.; Tolmasky, M.E.

Mutagenesis analysis of a conserved region involved in acetyl coenzyme A binding in the aminoglycoside 6'-N-acetyltransferase type Ib encoded by plasmid pJHCMW1

Antimicrob. Agents Chemother.

2979-2982

2005

Escherichia coli

15980378

658002

Draker, K.A.; Northrop, D.B.; Wright, G.D.

Kinetic mechanism of the GCN5-related chromosomal aminoglycoside acetyltransferase AAC(6')-Ii from Enterococcus faecium: evidence of dimer subunit cooperativity

Biochemistry

6565-6574

2003

Enterococcus faecium

12767240

658066

Draker, K.A.; Wright, G.D.

Molecular mechanism of the enterococcal aminoglycoside 6'-N-acetyltransferase': role of GNAT-conserved residues in the chemistry of antibiotic inactivation

Biochemistry

446-454

2004

Enterococcus faecium

14717599

658426

Vetting, M.W.; Magnet, S.; Nieves, E.; Roderick, S.L.; Blanchard, J.S.

A bacterial acetyltransferase capable of regioselective N-acetylation of antibiotics and histones

Chem. Biol.

565-573

2004

Salmonella enterica

15123251

658998

Li, X.Z.; Zhang, L.; McKay, G.A.; Poole, K.

Role of the acetyltransferase AAC(6')-Iz modifying enzyme in aminoglycoside resistance in Stenotrophomonas maltophilia

J. Antimicrob. Chemother.

803-811

2003

Stenotrophomonas maltophilia

12654758

659093

Hamano, Y.; Hoshino, Y.; Nakamori, S.; Takagi, H.

Overexpression and characterization of an aminoglycoside 6'-N-acetyltransferase with broad specificity from an epsilon-poly-L-lysine producer, Streptomyces albulus IFO14147

J. Biochem.

136

517-524

2004

Streptomyces albulus (Q764C8), Streptomyces albulus, Streptomyces albulus IFO14147 (Q764C8), Streptomyces albulus IFO14147

15625322

659193

Boehr, D.D.; Jenkins, S.I.; Wright, G.D.

The molecular basis of the expansive substrate specificity of the antibiotic resistance enzyme aminoglycoside acetyltransferase-6'-aminoglycoside phosphotransferase-2". The role of Asp-99 as an active site base important for acetyl transfer

J. Biol. Chem.

278

12873-12880

2003

Enterococcus sp.

12566434

671064

Burk, D.L.; Xiong, B.; Breitbach, C.; Berghuis, A.M.

Structures of aminoglycoside acetyltransferase AAC(6)-Ii in a novel crystal form: structural and normal-mode analyses

Acta Crystallogr. Sect. D

D61

1273-1279

2005

Enterococcus faecium

16131761

671333

Gao, F.; Yan, X.; Baettig, O.M.; Berghuis, A.M.; Auclair, K.

Regio- and chemoselective 6-N-derivatization of amino-glycosides: bi-substrate inhibitors as probes to study amino-glycoside 6-N-acetyltransferase

Angew. Chem. Int. Ed. Engl.

6859-6862

2005

Enterococcus faecium

16206301

672194

Kim, C.; Hesek, D.; Zajicek, J.; Vakulenko, S.B.; Mobashery, S.

Characterization of the bifunctional aminoglycoside-modifying enzyme ANT(3)-Ii/AAC(6)-IId from Serratia marcescens

Biochemistry

8368-8377

2006

Serratia marcescens

16819836

672253

Kim, C.; Villegas-Estrada, A.; Hesek, D.; Mobashery, S.

Mechanistic characterization of the bifunctional aminoglycoside-modifying enzyme AAC(3)-Ib/AAC(6)-Ib from Pseudomonas aeruginosa

Biochemistry

5270-5282

2007

Pseudomonas aeruginosa

17417880

672563

Yan, X.; Gao, F.; Yotphan, S.; Bakirtzian, P.; Auclair, K.

The use of aminoglycoside derivatives to study the mechanism of aminoglycoside 6-N-acetyltransferase and the role of 6-NH2 in antibacterial activity

Bioorg. Med. Chem.

2944-2951

2007

Enterococcus faecium

17317190

673770

Filipova, M.; Bujdakova, H.; Drahovska, H.; Liskova, A.; Hanzen, J.

Occurrence of aminoglycoside-modifying-enzyme genes aac(6)-aph(2"), aph(3), ant(4) and ant(6) in clinical isolates of Enterococcus faecalis resistant to high-level of gentamicin and amikacin

Folia Microbiol. (Praha)

57-61

2006

Enterococcus faecalis

16821713

675305

Gao, F.; Yan, X.; Shakya, T.; Baettig, O.M.; Ait-Mohand-Brunet, S.; Berghuis, A.M.; Wright, G.D.; Auclair, K.

Synthesis and structure-activity relationships of truncated bisubstrate inhibitors of aminoglycoside 6-N-acetyltransferases

J. Med. Chem.

5273-5281

2006

Enterococcus faecium

16913716

684411

Chu, X.; Wu, L.; Liu, X.; Li, N.; Li, D.

Detection of broad-spectrum aminoglycoside antibiotics through fluorescence-labeling aminoglycoside acetyltransferase(6)-Ii

Anal. Biochem.

376

144-150

2008

Enterococcus faecium

18295586

685250

Magalhaes, M.L.; Vetting, M.W.; Gao, F.; Freiburger, L.; Auclair, K.; Blanchard, J.S.

Kinetic and structural analysis of bisubstrate inhibition of the Salmonella enterica aminoglycoside 6-N-acetyltransferase

Biochemistry

579-584

2008

Salmonella enterica

18095712

701732

Kitao, T.; Miyoshi-Akiyama, T.; Kirikae, T.

AAC(6)-Iaf, a novel aminoglycoside 6-N-acetyltransferase from multidrug-resistant Pseudomonas aeruginosa clinical isolates

Antimicrob. Agents Chemother.

2327-2334

2009

Pseudomonas aeruginosa (C4TGI5), Pseudomonas aeruginosa

19349516

702249

Vetting, M.W.; Park, C.H.; Hegde, S.S.; Jacoby, G.A.; Hooper, D.C.; Blanchard, J.S.

Mechanistic and structural analysis of aminoglycoside N-acetyltransferase AAC(6)-Ib and its bifunctional, fluoroquinolone-active AAC(6)-Ib-cr variant

Biochemistry

9825-9835

2008

Escherichia coli

18710261

702549

Gao, F.; Yan, X.; Zahr, O.; Larsen, A.; Vong, K.; Auclair, K.

Synthesis and use of sulfonamide-, sulfoxide-, or sulfone-containing aminoglycoside-CoA bisubstrates as mechanistic probes for aminoglycoside N-6-acetyltransferase

Bioorg. Med. Chem. Lett.

5518-5522

2008

Enterococcus faecium

18805003

703215

Gao, F.; Yan, X.; Auclair, K.

Synthesis of a phosphonate-linked aminoglycoside-coenzyme a bisubstrate and use in mechanistic studies of an enzyme involved in aminoglycoside resistance

Chemistry

2064-2070

2009

Enterococcus faecium

19152351

706524

Zaunbrecher, M.A.; Sikes, R.D.; Metchock, B.; Shinnick, T.M.; Posey, J.E.

Overexpression of the chromosomally encoded aminoglycoside acetyltransferase eis confers kanamycin resistance in Mycobacterium tuberculosis

Proc. Natl. Acad. Sci. USA

106

20004-20009

2009

Mycobacterium tuberculosis

19906990

718594

Caldwell, S.J.; Berghuis, A.M.

Small-angle X-ray scattering analysis of the bifunctional antibiotic resistance enzyme aminoglycoside (6) acetyltransferase-ie/aminoglycoside (2) phosphotransferase-ia reveals a rigid solution structure

Antimicrob. Agents Chemother.

1899-1906

2012

Staphylococcus aureus

22290965

719164

Kim, Y.T.; Jang, J.H.; Kim, H.C.; Kim, H.; Lee, K.R.; Park, K.S.; Lee, H.J.; Kim, Y.J.

Identification of strain harboring both aac(6)-Ib and aac(6)-Ib-cr variant simultaneously in Escherichia coli and Klebsiella pneumoniae

BMB Rep.

262-266

2011

Escherichia coli, Klebsiella pneumoniae

21524352

719603

Chowdhury, G.; Pazhani, G.P.; Nair, G.B.; Ghosh, A.; Ramamurthy, T.

Transferable plasmid-mediated quinolone resistance in association with extended-spectrum beta-lactamases and fluoroquinolone-acetylating aminoglycoside-6-N-acetyltransferase in clinical isolates of Vibrio fluvialis

Int. J. Antimicrob. Agents

169-173

2011

Vibrio fluvialis

21683552

735363

Smith, C.; Toth, M.; Bhattacharya, M.; Frase, H.; Vakulenko, S.

Structure of the phosphotransferase domain of the bifunctional aminoglycoside-resistance enzyme AAC(6)-Ie-APH(2")-Ia

Acta Crystallogr. Sect. D

1561-1571

2014

Staphylococcus warneri (Q7ATH7)

24914967

735443

Tada, T.; Miyoshi-Akiyama, T.; Shimada, K.; Shimojima, M.; Kirikae, T.

Novel 6'-N-aminoglycoside acetyltransferase AAC(6')-Iaj from a clinical isolate of Pseudomonas aeruginosa

Antimicrob. Agents Chemother.

96-100

2013

Pseudomonas aeruginosa (K0IV17), Pseudomonas aeruginosa, Pseudomonas aeruginosa NCGM1588 (K0IV17), Pseudomonas aeruginosa NCGM1588

23070167

735444

Lin, D.L.; Tran, T.; Alam, J.Y.; Herron, S.R.; Ramirez, M.S.; Tolmasky, M.E.

Inhibition of aminoglycoside 6-N-acetyltransferase type Ib by zinc: reversal of amikacin resistance in Acinetobacter baumannii and Escherichia coli by a zinc ionophore

Antimicrob. Agents Chemother.

4238-4241

2014

Acinetobacter baumannii, Acinetobacter baumannii 155

24820083

735445

Tada, T.; Miyoshi-Akiyama, T.; Dahal, R.K.; Mishra, S.K.; Shimada, K.; Ohara, H.; Kirikae, T.; Pokhrel, B.M.

Identification of a novel 6-N-aminoglycoside acetyltransferase, AAC(6)-Iak, from a multidrug-resistant clinical isolate of Stenotrophomonas maltophilia

Antimicrob. Agents Chemother.

6324-6327

2014

Stenotrophomonas maltophilia (V5XKM9), Stenotrophomonas maltophilia IOMTU250 (V5XKM9)

25092711

735446

Li, Y.; Green, K.D.; Johnson, B.R.; Garneau-Tsodikova, S.

Inhibition of aminoglycoside acetyltransferase resistance enzymes by metal salts

Antimicrob. Agents Chemother.

4148-4156

2015

Pseudomonas aeruginosa (Q8RPU6), Staphylococcus aureus

25941215

735451

Chiem, K.; Fuentes, B.A.; Lin, D.L.; Tran, T.; Jackson, A.; Ramirez, M.S.; Tolmasky, M.E.

Inhibition of aminoglycoside 6-N-acetyltransferase type Ib-mediated amikacin resistance in Klebsiella pneumoniae by zinc and copper pyrithione

Antimicrob. Agents Chemother.

5851-5853

2015

Klebsiella pneumoniae (Q7B8A1), Klebsiella pneumoniae

26169410

735730

Green, K.; Garneau-Tsodikova, S.

Domain dissection and characterization of the aminoglycoside resistance enzyme ANT(3'')-Ii/AAC(6')-IId from Serratia marcescens

Biochimie

1319-1325

2013

Serratia marcescens (Q8VQN7)

23485681

735759

Lin, D.L.; Tran, T.; Adams, C.; Alam, J.Y.; Herron, S.R.; Tolmasky, M.E.

Inhibitors of the aminoglycoside 6-N-acetyltransferase type Ib [AAC(6)-Ib] identified by in silico molecular docking

Bioorg. Med. Chem. Lett.

5694-5698

2013

Escherichia coli (Q6SJ71)

24011645

736322

Jin, W.; Wachino, J.; Kimura, K.; Yamada, K.; Arakawa, Y.

New plasmid-mediated aminoglycoside 6-N-acetyltransferase, AAC(6')-Ian, and ESBL, TLA-3, from a Serratia marcescens clinical isolate

J. Antimicrob. Chemother.

1331-1337

2015

Serratia marcescens (A0A0B6VRK1), Serratia marcescens, Serratia marcescens NUBL-11663 (A0A0B6VRK1)

25576529

755691

Stogios, P.; Kuhn, M.; Evdokimova, E.; Law, M.; Courvalin, P.; Savchenko, A.

Structural and biochemical characterization of Acinetobacter spp. aminoglycoside acetyltransferases highlights functional and evolutionary variation among antibiotic resistance enzymes

ACS Infect. Dis.

132-143

2017

Acinetobacter baumannii (Q43899), Acinetobacter haemolyticus (Q44057)

27785912

755693

Xu, Z.; Stogios, P.J.; Quaile, A.T.; Forsberg, K.J.; Patel, S.; Skarina, T.; Houliston, S.; Arrowsmith, C.; Dantas, G.; Savchenko, A.

Structural and functional survey of environmental aminoglycoside acetyltransferases reveals functionality of resistance enzymes

ACS Infect. Dis.

653-665

2017

uncultured bacterium (A0A059WZ16)

28756664

756795

Kim, D.; Thawng, C.; Lee, K.; Cha, C.

Revisiting polymorphic diversity of aminoglycoside N-acetyltransferase AAC(6)-Ib based on bacterial genomes of human, animal, and environmental origins

Front. Microbiol.

1831

2018

bacterium

30147681

756923

Chiem, K.; Hue, F.; Magallon, J.; Tolmasky, M.

Inhibition of aminoglycoside 6'-N-acetyltransferase type Ib-mediated amikacin resistance by zinc complexed with clioquinol, an ionophore active against tumors and neurodegenerative diseases

Int. J. Antimicrob. Agents

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Acinetobacter baumannii, Acinetobacter baumannii A155

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Tran, T.; Chiem, K.; Jani, S.; Arivett, B.; Lin, D.; Lad, R.; Jimenez, V.; Farone, M.; Debevec, G.; Santos, R.; Giulianotti, M.; Pinilla, C.; Tolmasky, M.

Identification of a small molecule inhibitor of the aminoglycoside 6-N-acetyltransferase type Ib [AAC(6)-Ib] using mixture-based combinatorial libraries

Int. J. Antimicrob. Agents

752-761

2018

Acinetobacter baumannii, Klebsiella pneumoniae, Klebsiella pneumoniae JHCK1, Acinetobacter baumannii A155

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Chiem, K.; Jani, S.; Fuentes, B.; Lin, D.; Rasche, M.; Tolmasky, M.

Identification of an inhibitor of the aminoglycoside 6'-N-acetyltransferase type Ib [AAC(6')-Ib] by glide molecular docking

MedChemComm

184-189

2016

Escherichia coli (Q6SJ71)

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Smith, C.; Bhattacharya, M.; Toth, M.; Stewart, N.; Vakulenko, S.

Aminoglycoside resistance profile and structural architecture of the aminoglycoside acetyltransferase AAC(6')-Im

Microb. Cell

402-410

2017

Escherichia coli (Q93ET8)

29234669

757606

Tada, T.; Miyoshi-Akiyama, T.; Shimada, K.; Dahal, R.; Mishra, S.; Ohara, H.; Kirikae, T.; Pokhrel, B.

A novel 6'-N-aminoglycoside acetyltransferase, AAC(6)-Ial, from a clinical isolate of Serratia marcescens

Microb. Drug Resist.

103-108

2016

Serratia marcescens (V5YUM6)

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758025

Tabatabaei, I.; Ruf, S.; Bock, R.

A bifunctional aminoglycoside acetyltransferase/phosphotransferase conferring tobramycin resistance provides an efficient selectable marker for plastid transformation

Plant Mol. Biol.

269-281

2017

Enterococcus faecalis (P0A0C2), Enterococcus faecalis ATCC 700802 (P0A0C2)

27858324