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2.3.1.82: aminoglycoside 6'-N-acetyltransferase

This is an abbreviated version!
For detailed information about aminoglycoside 6'-N-acetyltransferase, go to the full flat file.

Word Map on EC 2.3.1.82

Reaction

acetyl-CoA
+
kanamycin-B
=
CoA
 +
N6'-acetylkanamycin-B

Synonyms

6'-acetyltransferase-Im, 6'-N-acetyltransferase type Ib, AAC, aac(3)-Ib/aac(6')-Ib, AAC(3)-Ib/AAC(6')-Ib', AAC(6'), AAC(6')-I, AAC(6')-Iaf, AAC(6')-IaI, AAC(6')-Iaj, AAC(6')-Ian, AAC(6')-Ib, AAC(6')-Ib-cr, AAC(6')-Ie, AAC(6')-Ie/APH(2")-Ia, AAC(6')-Ie/APH(2'')-Ia, AAC(6')-Ie/APH(2')-Ia, AAC(6')-Ig, AAC(6')-Ih, AAC(6')-Ii, AAC(6')-Im, AAC(6')-Isa, AAC(6')-Iy, AAC(6')-Iz acetyltransferase, AAC(6)-Iak, aac(6)-Ib, AAC3-I, aacA-aphD, acetyltransferase, aminoglycoside 6'-N-, acetyltransferase, kanamycin, acetyltransferase-6'-aminoglycoside phosphotransferase-2", aminoglycoside (3) acetyltransferase AAC(3)-Ia, aminoglycoside 3-N-acetyltransferase/aminoglycoside 6'-N-acetyltransferase fusion protein, aminoglycoside 6'-acetyltransferase-Ie, aminoglycoside 6'-N-acetyltransferase, aminoglycoside 6'-N-acetyltransferase Ib, aminoglycoside 6'-N-acetyltransferase type Ib, aminoglycoside 6'-N-acetyltransferase type Ii, aminoglycoside 6-N-acetyltransferase, aminoglycoside acetyltransferase, aminoglycoside acetyltransferase eis, aminoglycoside acetyltransferase(6')-Ie/aminoglycoside phosphotransferase(2')-Ia, aminoglycoside N(6')-acetyltransferase type 1, aminoglycoside N-6'-acetyltransferase, aminoglycoside N-6'-acetyltransferase Ii, aminoglycoside N-acetyltransferase, aminoglycoside-6'-acetyltransferase, aminoglycoside-6'-N-acetyltransferase, aminoglycoside-6-N-acetyltransferase, ANT(3'')-Ii/AAC(6')-IId, EC 2.3.1.55, meta-AAC0020

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.82 aminoglycoside 6'-N-acetyltransferase

Inhibitors

Inhibitors on EC 2.3.1.82 - aminoglycoside 6'-N-acetyltransferase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl 2-amino-2,6-dideoxy-6-[(3-sulfanylpropanoyl)amino]-alpha-D-glucopyranoside-S-CoA
-
-
(1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl 2-amino-2,6-dideoxy-6-[(4-sulfanylbutanoyl)amino]-alpha-D-glucopyranoside-S-CoA
-
-
(1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl 2-amino-2,6-dideoxy-6-[(5-sulfanylpentanoyl)amino]-alpha-D-glucopyranoside-S-CoA
-
-
(1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl 2-amino-2,6-dideoxy-6-[(sulfanylacetyl)amino]-alpha-D-glucopyranoside-S-CoA
-
-
(1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl 2-amino-2,6-dideoxy-6-[[(2-sulfanylethyl)sulfonyl]amino]-alpha-D-glucopyranoside-S-CoA
-
-
(1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl 2-amino-2,6-dideoxy-6-[[(dioxidosulfanyl)acetyl]amino]-alpha-D-glucopyranoside-S-CoA
-
-
(1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl 2-amino-2,6-dideoxy-6-[[(oxidosulfanyl)acetyl]amino]-alpha-D-glucopyranoside-S-CoA
-
-
(1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl 2-amino-2,6-dideoxy-6-[[3-(dioxidosulfanyl)propanoyl]amino]-alpha-D-glucopyranoside-S-CoA
-
-
(1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl 2-amino-2,6-dideoxy-6-[[3-(oxidosulfanyl)propanoyl]amino]-alpha-D-glucopyranoside-S-CoA
-
-
(1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl 2-amino-2-deoxy-6-O-[methoxy(2-sulfanylethyl)phosphoryl]-alpha-D-glucopyranoside-S-CoA
-
-
(2S)-3-[(2S)-2-([[(1S)-2-amino-1-phenylethyl]amino]methyl)pyrrolidin-1-yl]-2-([(2S)-2-phenyl-2-[(3-phenylbutyl)amino]ethyl]amino)propan-1-ol
1-(bromomethyl)phenanthrene
-
inactivates through covalent modification of Asp99
1-[3-(2-aminoethyl)benzyl]-3-(piperidin-1-ylmethyl)pyrrolidin-3-ol
the growth of an amikacin-resistant Acinetobacter baumannii clinical strain is inhibited in the presence of a combination of amikacin and compound
2-[5-[(4,6-dioxo-1,3-diphenyl-2-thioxotetrahydro-5(2H)-pyrimidinylidene)methyl]-2-furyl]benzoic acid
identified by in silico molecular docking, micromolar activity in inhibiting acetylation of kanamycin A
4-[(2-[[1-(3-methylphenyl)-4,6-dioxo-2-thioxotetrahydro-5(2H)-pyrimidinylidene]methyl]phenoxy)methyl]benzoic acid
identified by in silico molecular docking, micromolar activity in inhibiting acetylation of kanamycin A
6'-N-acetylkanamycin A
-
competitive versus kanamycin A and noncompetitive/mixed versus acetyl-CoA
6'-N-acetylneamine
-
product inhibition
amikacin
-
substrate inhibition
butyryl-CoA
clioquinol
-
Zn2+ in complex with clioquinol reduces resistance to amikacin in Acinetobacter baumannii and Escherichia coli harboring aac(6')-Ib. In the absence of Zn2+, clioquinol does not display inhibitory activity
CoA
-
product inhibition
CoA-aminoglycoside 1
-
-
CoA-aminoglycoside 11a
-
-
CoA-aminoglycoside 11b
-
-
CoA-aminoglycoside 11c
-
-
CoA-aminoglycoside 1a
-
-
CoA-aminoglycoside 1b
-
-
CoA-aminoglycoside 1c
-
-
CoA-aminoglycoside 1d
-
-
CoA-aminoglycoside 2
-
-
CoA-aminoglycoside 3
-
-
CoA-aminoglycoside 4a
-
competitive
CoA-aminoglycoside 4b
-
competitive
CoA-aminoglycoside 4c
-
competitive
CoA-aminoglycoside 4d
-
competitive
CoA-aminoglycoside 4e
-
competitive
CoA-aminoglycoside 4f
-
competitive
CoA-aminoglycoside 5b
-
competitive
CoA-aminoglycoside 5d
-
competitive
CoA-aminoglycoside 5e
-
competitive
CoASH
Cu2+
the growth of an amikacin-resistant Klebsiella pneumoniae strain is inhibited when amikacin is supplemented by the addition of Zn2+ or Cu2+ in complex with the ionophore pyrithione
dithio-CoA
-
-
gentamicin
-
substrate inhibition
gentamicin A
-
-
gentamicin C1
gentamine A
-
-
iodoacetamide
-
inactivation in a biphasic manner, half of the activity is lost rapidly and the other half more slowly, tobramycin but not acetyl-CoA protects
kanamycin A
-
-
kanamycin B
-
-
lividomycin
-
-
lividomycin A
-
-
N6'-acetyl kanamycin A
-
-
N6'-Acetylgentamicin C1a
-
-
N6'-acetylneomycin B
-
-
netilmicin
paromamine
-
-
paromomycin
Pefloxacin
-
-
poly-L-Lys
substrate inhibition
tobramycin
additional information
-
no inhibition by GTP
-