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0.049
2'-N-ethyl netilmicin
S 0.5 value, Hill coefficient 1.39, pH 8.0, 37°C
0.0183
2'-N-ethylnetilmicin
S 0.5 value, Hill coefficient 2.28, pH 8.0, 37°C
0.0033 - 0.215
acetyl-CoA
0.014
butirosin
-
pH 6.0, 37°C
0.0173 - 0.0216
butirosin A
9.3
butyryl-CoA
-
reaction with tobramycin, wild-type enzyme
0.07
Ciprofloxacin
-
AAC(6')-Ib-cr variant
0.00038 - 0.582
dibekacin
0.0254 - 0.07
fortimicin A
0.00504 - 0.653
gentamicin
0.0223
gentamicin B
-
pH 6.0, 37°C
0.0082
gentamicin C
-
wild-type enzyme
0.022
gentamycin
K 0.5 value, Hill coefficient 3.14, pH 7.5, 25°C
0.0003 - 0.404
isepamicin
0.00202 - 0.346
kanamycin
0.00027 - 0.9
kanamycin B
0.04188
lividomycin A
pH 8.0, 30°C
0.0686
n-butyryl-CoA
pH 8.0, 30°C, cosubstrate: sisomycin
0.0161
n-propionyl-CoA
pH 8.0, 30°C, cosubstrate: sisomycin
0.00052 - 0.02
neomycin B
0.00531 - 0.25
neomycin C
0.067
Norfloxacin
-
AAC(6')-Ib-cr variant
0.324 - 0.771
paromomycin
0.038
poly-L-Lys
pH 7.5, 37°C
0.0195 - 0.27
propionyl-CoA
0.0062 - 0.306
ribostamycin
0.0029 - 0.216
tobramicin
0.00353 - 1.15
tobramycin
0.0033
acetyl-CoA
-
pH 6.0, 37°C, mutant enzyme L76A
0.0041
acetyl-CoA
-
pH 6.0, 37°C, mutant enzyme Y147F
0.0047
acetyl-CoA
-
pH 6.0, 37°C, mutant enzyme Y147A
0.0053
acetyl-CoA
-
AAC(6')-Ib-cr variant
0.0073
acetyl-CoA
-
pH 6.0, 37°C, mutant enzyme H74A
0.009
acetyl-CoA
-
reaction with AAC (6?)-Ib' domain
0.01
acetyl-CoA
-
reaction with tobramycin
0.0158
acetyl-CoA
-
wild-type enzyme
0.017
acetyl-CoA
-
reaction with tobramycin, mutant enzyme C109A
0.017
acetyl-CoA
-
pH 7.5, 37°C, mutant AAC(6')-Ie D99E
0.0187
acetyl-CoA
pH 8.0, 30°C, cosubstrate: sisomycin
0.021
acetyl-CoA
K 0.5 value, Hill coefficient 1.77, pH 7.5, 25°C
0.0235
acetyl-CoA
-
pH 6.0, 37°C
0.0235
acetyl-CoA
-
pH 6.0, 37°C, wild-type enzyme
0.035
acetyl-CoA
-
AAC(6')-Ib, wild type
0.038
acetyl-CoA
-
pH 7.5, 37°C,wild-type AAC(6')-Ie
0.0399
acetyl-CoA
-
pH 7.5, 37°C, mutant AAC(6')-Ie D99N
0.044
acetyl-CoA
-
pH 7.5
0.0453
acetyl-CoA
-
pH 7.5, 37°C, mutant AAC(6')-Ie D99A
0.0489
acetyl-CoA
-
pH 6.0, 37°C, mutant enzyme L76P
0.07
acetyl-CoA
-
reaction with tobramycin, mutant enzyme C109A/C70A
0.0736
acetyl-CoA
-
pH 7.5, 37°C, mutant AAC(6')-Ie Y96F
0.108
acetyl-CoA
-
AAC(6')-Ib-cr variant
0.147
acetyl-CoA
isolated AAC(6') domain, pH 7.5, 25°C
0.154
acetyl-CoA
-
pH 6.0, 37°C, mutant enzyme E72A
0.215
acetyl-CoA
full length enzyme, pH 7.5, 25°C
0.00055
amikacin
full length enzyme, pH 7.5, 25°C
0.001
amikacin
-
reaction with AAC (6?)-Ib' domain
0.00434
amikacin
pH 8.0, 30°C
0.0114
amikacin
-
pH 6.0, 37°C, mutant enzyme L76A
0.0131
amikacin
-
pH 6.0, 37°C
0.0131
amikacin
-
pH 6.0, 37°C, wild-type enzyme
0.032
amikacin
pH not specified in the publication, temperature not specified in the publication
0.036
amikacin
-
pH 7.5, 37°C
0.0441
amikacin
S 0.5 value, Hill coefficient 1.55, pH 8.0, 37°C
0.05
amikacin
-
wild-type enzyme
0.0582
amikacin
-
pH 6.0, 37°C, mutant enzyme H74A
0.0693
amikacin
-
wild-type enzyme
0.075
amikacin
-
mutant enzyme C109A
0.086
amikacin
pH not specified in the publication, temperature not specified in the publication
0.0996
amikacin
S 0.5 value, Hill coefficient 1.26, pH 8.0, 37°C
0.127
amikacin
isolated AAC(6') domain, pH 7.5, 25°C
0.364
amikacin
-
pH 6.5, 37°C
0.38
amikacin
-
pH 6.0, 37°C, mutant enzyme E72A
0.571
amikacin
-
pH 5.5, 37°C
2.19
amikacin
-
pH 6.0, 37°C, mutant enzyme Y147F
0.0059
arbekacin
S 0.5 value, Hill coefficient 2.5, pH 8.0, 37°C
0.0139
arbekacin
S 0.5 value, Hill coefficient 2.19, pH 8.0, 37°C
0.036
arbekacin
pH not specified in the publication, temperature not specified in the publication
0.399
arbekacin
pH not specified in the publication, temperature not specified in the publication
0.0173
butirosin A
S 0.5 value, Hill coefficient 1.77, pH 8.0, 37°C
0.0216
butirosin A
S 0.5 value, Hill coefficient 2.03, pH 8.0, 37°C
0.00038
dibekacin
pH 8.0, 30°C
0.003
dibekacin
-
reaction with AAC (6?)-Ib' domain
0.0098
dibekacin
S 0.5 value, Hill coefficient 1.42, pH 8.0, 37°C
0.024
dibekacin
pH not specified in the publication, temperature not specified in the publication
0.0259
dibekacin
S 0.5 value, Hill coefficient 1.26, pH 8.0, 37°C
0.03
dibekacin
-
wild-type enzyme
0.036
dibekacin
-
pH 6.0, 37°C
0.582
dibekacin
pH not specified in the publication, temperature not specified in the publication
0.0254
fortimicin A
-
pH 7.5, 37°C, wild-type AAC(6')-Ie
0.0435
fortimicin A
-
pH 7.5, 37°C, mutant AAC(6')-Ie Y96F
0.07
fortimicin A
-
pH 7.5, 37°C, mutant AAC(6')-Ie D99E
0.00504
gentamicin
full length enzyme, pH 7.5, 25°C
0.0083
gentamicin
-
reaction with AAC (6?)-Ib' domain
0.0087
gentamicin
S 0.5 value, Hill coefficient 1.84, pH 8.0, 37°C
0.0143
gentamicin
isolated AAC(6') domain, pH 7.5, 25°C
0.015
gentamicin
-
pH 7.5
0.0176
gentamicin
S 0.5 value, Hill coefficient 2.05, pH 8.0, 37°C
0.077
gentamicin
-
pH 7.5, 37°C
0.297
gentamicin
-
pH 6.5, 37°C
0.653
gentamicin
-
pH 5.5, 37°C
0.0003
isepamicin
-
reaction with AAC (6?)-Ib' domain
0.044
isepamicin
pH not specified in the publication, temperature not specified in the publication
0.104
isepamicin
S 0.5 value, Hill coefficient 1.45, pH 8.0, 37°C
0.111
isepamicin
S 0.5 value, Hill coefficient 1.48, pH 8.0, 37°C
0.404
isepamicin
pH not specified in the publication, temperature not specified in the publication
0.00202
kanamycin
full length enzyme, pH 7.5, 25°C
0.016
kanamycin
isolated AAC(6') domain, pH 7.5, 25°C
0.03
kanamycin
pH not specified in the publication, temperature not specified in the publication
0.322
kanamycin
pH not specified in the publication, temperature not specified in the publication
0.346
kanamycin
K 0.5 value, Hill coefficient 0.62, pH 7.5, 25°C
0.001
kanamycin A
-
pH 7.5
0.001
kanamycin A
-
pH 6.0
0.001
kanamycin A
-
reaction with AAC (6?)-Ib' domain
0.005
kanamycin A
-
pH 6.0
0.006
kanamycin A
-
pH 7.5
0.0074
kanamycin A
pH 8.0, 30°C
0.0114
kanamycin A
-
wild-type enzyme
0.012
kanamycin A
-
pH 7.5
0.0144
kanamycin A
-
pH 6.0, 37°C, mutant enzyme H74A
0.0199
kanamycin A
-
pH 6.0, 37°C
0.0199
kanamycin A
-
pH 6.0, 37°C, wild-type enzyme
0.0257
kanamycin A
-
pH 6.0, 37°C, mutant enzyme L76A
0.031
kanamycin A
-
pH 7.5, 37°C, wild-type AAC(6')-Ie
0.079
kanamycin A
-
pH 7.5, 37°C, mutant AAC(6')-Ie Y96F
0.0902
kanamycin A
-
pH 7.5, 37°C, mutant AAC(6')-Ie D99N
0.102
kanamycin A
-
pH 7.5, 37°C, mutant AAC(6')-Ie D99E
0.105
kanamycin A
-
wild-type enzyme
0.11
kanamycin A
-
pH 6.0, 37°C, mutant enzyme Y147A
0.34
kanamycin A
-
pH 6.0, 37°C, mutant enzyme Y147F
0.771
kanamycin A
-
pH 7.5, 37°C, mutant AAC(6')-Ie D99A
3.49
kanamycin A
-
pH 6.0, 37°C, mutant enzyme E72A
0.00027
kanamycin B
-
AAC(6')-Ib, wild type
0.0067
kanamycin B
-
AAC(6')-Ib-cr variant
0.012
kanamycin B
S 0.5 value, Hill coefficient 2.30, pH 8.0, 37°C
0.017
kanamycin B
-
mutant enzyme C109A
0.0189
kanamycin B
-
pH 6.0, 37°C
0.029
kanamycin B
S 0.5 value, Hill coefficient 1.93, pH 8.0, 37°C
0.079
kanamycin B
-
wild-type enzyme
0.9
kanamycin B
-
mutant enzyme C109A/C70A
0.58
malonyl-CoA
pH 8.0, 30°C, cosubstrate: sisomycin
0.82
malonyl-CoA
-
reaction with tobramycin, wild-type enzyme
0.0058
neamine
-
pH 6.0, 37°C, wild-type enzyme
0.00582
neamine
-
pH 6.0, 37°C
0.0224
neamine
-
pH 6.0, 37°C, mutant enzyme L76A
0.0432
neamine
-
pH 6.0, 37°C, mutant enzyme H74A
0.0682
neamine
-
pH 6.0, 37°C, mutant enzyme L76P
0.078
neamine
-
pH 7.5, 37°C, wild-type AAC(6')-Ie
0.15
neamine
-
pH 6.0, 37°C, mutant enzyme Y147F
0.169
neamine
-
pH 6.0, 37°C, mutant enzyme Y147A
0.229
neamine
-
pH 7.5, 37°C, mutant AAC(6')-Ie D99E
0.326
neamine
-
pH 7.5, 37°C, mutant AAC(6')-Ie Y96F
0.443
neamine
-
pH 7.5, 37°C, mutant AAC(6')-Ie D99A
0.482
neamine
-
pH 6.0, 37°C, mutant enzyme E72A
0.509
neamine
-
pH 7.5, 37°C, mutant AAC(6')-Ie D99N
0.0012
neomycin
-
reaction with AAC (6?)-Ib' domain
0.0039
neomycin
-
wild-type enzyme
0.0053
neomycin
-
pH 6.0, 37°C, wild-type enzyme
0.01
neomycin
pH not specified in the publication, temperature not specified in the publication
0.0182
neomycin
-
pH 6.0, 37°C, mutant enzyme H74A
0.019
neomycin
-
pH 6.0, 37°C, mutant enzyme L76A
0.023
neomycin
full length enzyme, pH 7.5, 25°C
0.029
neomycin
-
pH 6.0, 37°C, mutant enzyme E72A
0.0321
neomycin
isolated AAC(6') domain, pH 7.5, 25°C
0.0386
neomycin
-
pH 6.0, 37°C, mutant enzyme Y147A
0.0553
neomycin
-
pH 6.0, 37°C, mutant enzyme Y147F
0.0573
neomycin
-
pH 6.0, 37°C, mutant enzyme L76P
0.47
neomycin
pH not specified in the publication, temperature not specified in the publication
0.00052
neomycin B
pH 8.0, 30°C
0.02
neomycin B
-
AAC(6')-Ib, wild type
0.00531
neomycin C
-
pH 6.0, 37°C
0.0074
neomycin C
S 0.5 value, Hill coefficient 1.43, pH 8.0, 37°C
0.0079
neomycin C
S 0.5 value, Hill coefficient 2.05, pH 8.0, 37°C
0.014
neomycin C
-
wild-type enzyme
0.25
neomycin C
-
mutant enzyme C109A/C70A
0.001
netilmicin
-
reaction with AAC (6?)-Ib' domain
0.00177
netilmicin
full length enzyme, pH 7.5, 25°C
0.00387
netilmicin
isolated AAC(6') domain, pH 7.5, 25°C
0.006
netilmicin
-
mutant enzyme C109A
0.00638
netilmicin
-
pH 6.0, 37°C
0.008
netilmicin
-
wild-type enzyme
0.023
netilmicin
pH not specified in the publication, temperature not specified in the publication
0.036
netilmicin
-
pH 7.5
0.07
netilmicin
pH not specified in the publication, temperature not specified in the publication
0.259
netilmicin
-
pH 7.5, 37°C
0.46
netilmicin
-
mutant enzyme C109A/C70A
2.44
netilmicin
-
pH 6.5, 37°C
0.324
paromomycin
-
pH 7.5, 37°C, wild-type AAC(6')-Ie
0.771
paromomycin
-
pH 7.5, 37°C, mutant AAC(6')-Ie Y96F
0.0195
propionyl-CoA
-
pH 6.0, 37°C
0.27
propionyl-CoA
-
reaction with tobramycin, wild-type enzyme
0.0062
ribostamycin
S 0.5 value, Hill coefficient 1.92, pH 8.0, 37°C
0.00908
ribostamycin
-
pH 6.0, 37°C
0.0091
ribostamycin
-
pH 6.0, 37°C, wild-type enzyme
0.0118
ribostamycin
S 0.5 value, Hill coefficient 1.96, pH 8.0, 37°C
0.016
ribostamycin
full length enzyme, pH 7.5, 25°C
0.0214
ribostamycin
-
pH 6.0, 37°C, mutant enzyme L76A
0.0381
ribostamycin
-
pH 6.0, 37°C, mutant enzyme H74A
0.05
ribostamycin
-
wild-type enzyme
0.0693
ribostamycin
isolated AAC(6') domain, pH 7.5, 25°C
0.107
ribostamycin
-
pH 6.0, 37°C, mutant enzyme L76P
0.109
ribostamycin
-
pH 6.0, 37°C, mutant enzyme Y147A
0.301
ribostamycin
-
pH 6.0, 37°C, mutant enzyme E72A
0.306
ribostamycin
-
pH 6.0, 37°C, mutant enzyme Y147F
0.0022
sisomicin
full length enzyme, pH 7.5, 25°C
0.00324
sisomicin
pH 8.0, 30°C
0.004
sisomicin
pH not specified in the publication, temperature not specified in the publication
0.0049
sisomicin
isolated AAC(6') domain, pH 7.5, 25°C
0.0105
sisomicin
S 0.5 value, Hill coefficient 1.93, pH 8.0, 37°C
0.0117
sisomicin
-
pH 6.0, 37°C
0.012
sisomicin
-
wild-type enzyme
0.012
sisomicin
pH not specified in the publication, temperature not specified in the publication
0.0168
sisomicin
S 0.5 value, Hill coefficient 2.04, pH 8.0, 37°C
0.038
sisomicin
K 0.5 value, Hill coefficient 4.39, pH 7.5, 25°C
0.0029
tobramicin
S 0.5 value, Hill coefficient 2.12, pH 8.0, 37°C
0.022
tobramicin
S 0.5 value, Hill coefficient 1.21, pH 8.0, 37°C
0.216
tobramicin
-
pH 5.5, 37°C
0.00353
tobramycin
pH 8.0, 30°C
0.0037
tobramycin
-
wild-type enzyme
0.0079
tobramycin
full length enzyme, pH 7.5, 25°C
0.0148
tobramycin
isolated AAC(6') domain, pH 7.5, 25°C
0.016
tobramycin
pH not specified in the publication, temperature not specified in the publication
0.022
tobramycin
-
pH 6.0, 37°C
0.022
tobramycin
-
pH 6.0, 37°C, wild-type enzyme
0.026
tobramycin
-
pH 7.5, 37°C
0.026
tobramycin
-
mutant enzyme C109A
0.028
tobramycin
pH not specified in the publication, temperature not specified in the publication
0.028
tobramycin
K 0.5 value, Hill coefficient 2.3, pH 7.5, 25°C
0.0369
tobramycin
-
pH 6.0, 37°C, mutant enzyme H74A
0.066
tobramycin
-
wild-type enzyme
0.077
tobramycin
-
pH 6.5, 37°C
0.136
tobramycin
-
pH 6.0, 37°C, mutant enzyme Y147F
0.146
tobramycin
-
pH 6.0, 37°C, mutant enzyme L76P
0.147
tobramycin
-
pH 6.0, 37°C, mutant enzyme Y147A
0.54
tobramycin
-
mutant enzyme C109A/C70A
0.62
tobramycin
-
pH 6.0, 37°C, mutant enzyme L76A
1.15
tobramycin
-
pH 6.0, 37°C, mutant enzyme E72A