2.3.1.254: N-terminal methionine Nalpha-acetyltransferase NatB

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For detailed information about N-terminal methionine Nalpha-acetyltransferase NatB, go to the full flat file.

Reaction

Synonyms

CRA-1, EC 2.3.1.88, MDM20, Mdm20p, N-acetyltransferase 3, N-terminal acetyltransferase, N-terminal acetyltransferase B complex catalytic subunit NAA20, NAA20, NAA25, Naa50p, NAT3, Nat3p, NAT5/SAN, natB, NatB N-alpha-terminal acetylation complex, TCU2

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.1 Transferring groups other than aminoacyl groups

                2.3.1.254 N-terminal methionine Nalpha-acetyltransferase NatB

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Results	in table
49	AA Sequence
2	Cloned(Commentary)
5	Cofactor
1	Crystallization (Commentary)
23	Disease/ Diagnostics
35	General Information
1	Inhibitors
10	KM Value [mM]
5	Localization
35	Natural Substrates/ Products (Substrates)
86	Organism
2	Pathway
2	PDB ID
1	pH Optimum
36	Protein Variants
2	Purification (Commentary)
4	Reaction
15	Reference
6	Source Tissue
58	Substrates and Products (Substrate)
9	Subunits
55	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
6	Turnover Number [1/s]

Disease

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Disease on EC 2.3.1.254 - N-terminal methionine Nalpha-acetyltransferase NatB

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DISEASE

TITLE OF PUBLICATION

LINK TO PUBMED

Carcinogenesis

Naa20, the catalytic subunit of NatB complex, contributes to hepatocellular carcinoma by regulating the LKB1-AMPK-mTOR axis.

33219302

Carcinoma, Hepatocellular

Naa20, the catalytic subunit of NatB complex, contributes to hepatocellular carcinoma by regulating the LKB1-AMPK-mTOR axis.

33219302

Influenza, Human

N-Terminal Acetylation by NatB Is Required for the Shutoff Activity of Influenza A Virus PA-X.

30044982

Intellectual Disability

Missense NAA20 variants impairing the NatB protein N-terminal acetyltransferase cause autosomal recessive developmental delay, intellectual disability, and microcephaly.

34230638

Ischemic Stroke

The relationship between the prognosis of children with acute arterial stroke and polymorphisms of CDKN2B, HDAC9, NINJ2, NAA25 genes.

30656483

Microcephaly

Missense NAA20 variants impairing the NatB protein N-terminal acetyltransferase cause autosomal recessive developmental delay, intellectual disability, and microcephaly.

34230638

Neoplasms

Naa20, the catalytic subunit of NatB complex, contributes to hepatocellular carcinoma by regulating the LKB1-AMPK-mTOR axis.

33219302

Stroke

The relationship between the prognosis of children with acute arterial stroke and polymorphisms of CDKN2B, HDAC9, NINJ2, NAA25 genes.

30656483

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