2.3.1.212: benzalacetone synthase
This is an abbreviated version!
For detailed information about benzalacetone synthase, go to the full flat file.
Word Map on EC 2.3.1.212
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2.3.1.212
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polyketide
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chalcone
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palmatum
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rheum
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plant-specific
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raspberry
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diketide
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phenylbutanoids
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flavor
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unnatural
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p-coumaric
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4-coumarate
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synthesis
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stilbene
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phenylpropanoids
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crispum
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idaeus
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methylmalonyl-coa
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cuspidatum
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condensations
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naringenin
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arachis
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polygonum
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petroselinum
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baicalensis
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fragrance
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rhubarb
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scutellaria
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tetraketide
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quinolone
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rubus
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p-coumaroyl-coa
- 2.3.1.212
- polyketide
- chalcone
- palmatum
- rheum
-
plant-specific
- raspberry
-
diketide
-
phenylbutanoids
-
flavor
-
unnatural
-
p-coumaric
- 4-coumarate
- synthesis
- stilbene
-
phenylpropanoids
- crispum
- idaeus
- methylmalonyl-coa
- cuspidatum
-
condensations
- naringenin
- arachis
-
polygonum
-
petroselinum
- baicalensis
-
fragrance
- rhubarb
-
scutellaria
-
tetraketide
-
quinolone
-
rubus
- p-coumaroyl-coa
Reaction
Synonyms
bAS, HsPKS3, PKS1, RinPKS1, RiPKS4, RpBAS
ECTree
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Reaction
Reaction on EC 2.3.1.212 - benzalacetone synthase
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4-coumaroyl-CoA + malonyl-CoA + H2O = 2 CoA + 4-hydroxybenzalacetone + 2 CO2
the enzyme shows remarkable substrate tolerance and catalytic versatility, structure-function relationship and functional diversity of type III PKS enzymes, the enzyme catalytic mechanism for the thioester bond cleavage of the enzyme-bound diketide intermediate and the decarboxylation reaction to produce benzalacetone involves Cys164, His33, and Asn336, overview. RpBAS initially accepts the aminoacyl-CoA as a starter, and then recruits malonyl-CoA for a Claisen condensation to generate the gamma-amino-beta-ketothioester. The free gamma-amino group of the enzyme-bound intermediate can cleave the thioester bond, with concomitant intramolecular lactamization