2.1.1.375: NNS virus cap methyltransferase

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For detailed information about NNS virus cap methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.375

2.1.1.375

stomatitis

vesicular

rna-dependent

polyadenylation

non-segmented

unconventional

negative-strand

gdp

guanylyltransferase

rhabdoviruses

methylase

parainfluenza

nucleocapsids

mononegavirales

polyribonucleotidyltransferase

ppprna

rhabdoviridae

phosphoprotein

guanine-n-7

prntase

stock

Reaction

2 S-adenosyl-L-methionine +

= 2 S-adenosyl-L-homocysteine +

Synonyms

RNA-directed RNA polymerase L, VSV L

ECTree

2 Transferases

2.1 Transferring one-carbon groups

2.1.1 Methyltransferases

2.1.1.375 NNS virus cap methyltransferase

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Results	in table
4080	AA Sequence
1	Cloned(Commentary)
3	Crystallization (Commentary)
4	General Information
1	Metals/Ions
6	Natural Substrates/ Products (Substrates)
30	Organism
1	pH Optimum
37	Protein Variants
3	Reaction
10	Reference
12	Substrates and Products (Substrate)
6	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

Systematic Name

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Systematic Name on EC 2.1.1.375 - NNS virus cap methyltransferase

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S-adenosyl-L-methionine:G(5')pppAACA-[mRNA] N7,2'-O-methyltransferase

The enzyme from non-segmented negative strain (NNS) viruses (e.g. rhabdoviruses) catalyses two successive methylations. In higher eukaryotes the two methylations occur in the reverse order and are catalysed by two different enzymes (cf. EC 2.1.1.56, mRNA (guanine-N7)-methyltransferase, and EC 2.1.1.57, methyltransferase cap1) that do not required a specific motif.