2.1.1.375: NNS virus cap methyltransferase
This is an abbreviated version!
For detailed information about NNS virus cap methyltransferase, go to the full flat file.
Word Map on EC 2.1.1.375
-
2.1.1.375
-
stomatitis
-
vesicular
-
rna-dependent
-
polyadenylation
-
non-segmented
-
unconventional
-
negative-strand
-
gdp
-
guanylyltransferase
-
rhabdoviruses
-
methylase
-
parainfluenza
-
nucleocapsids
-
mononegavirales
-
polyribonucleotidyltransferase
-
ppprna
-
rhabdoviridae
-
phosphoprotein
-
guanine-n-7
-
prntase
-
stock
- 2.1.1.375
-
stomatitis
-
vesicular
-
rna-dependent
-
polyadenylation
-
non-segmented
-
unconventional
-
negative-strand
- gdp
-
guanylyltransferase
-
rhabdoviruses
-
methylase
-
parainfluenza
-
nucleocapsids
-
mononegavirales
-
polyribonucleotidyltransferase
- ppprna
-
rhabdoviridae
- phosphoprotein
-
guanine-n-7
- prntase
-
stock
Reaction
2 S-adenosyl-L-methionine + = 2 S-adenosyl-L-homocysteine +
Synonyms
RNA-directed RNA polymerase L, VSV L
ECTree
Advanced search results
General Information
General Information on EC 2.1.1.375 - NNS virus cap methyltransferase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
metabolism
physiological function
vesicular stomatitis virus L protein typically modifies the 2'-Oposition of the cap prior to the G-N-7 position and G-N-7 methylation is diminished by pre-2'-O methylation of the substrate RNA. Amino acid substitutions in the C terminus of L that prevent all cap methylation in recombinant VSV partially retain the ability to G-N-7 methylate a pre-2'-O-methylated RNA, therefore uncoupling the effect of substitutions in the C terminus of the L protein on the two methylations. The 2'-O and G-N-7 methylase activities act specifically on RNA substrates that contain the conserved elements of a vesicular stomatitis virus mRNA start at the 5'-terminus
metabolism
-
vesicular stomatitis virus L protein typically modifies the 2'-Oposition of the cap prior to the G-N-7 position and G-N-7 methylation is diminished by pre-2'-O methylation of the substrate RNA. Amino acid substitutions in the C terminus of L that prevent all cap methylation in recombinant VSV partially retain the ability to G-N-7 methylate a pre-2'-O-methylated RNA, therefore uncoupling the effect of substitutions in the C terminus of the L protein on the two methylations. The 2'-O and G-N-7 methylase activities act specifically on RNA substrates that contain the conserved elements of a vesicular stomatitis virus mRNA start at the 5'-terminus
-
enzyme functions for both 2'-O and G-N-7 methylations during RNA cap formation. VSV L typically modifies the 2'-O position of the cap prior to the G-N-7 position and G-N-7 methylation is diminished by pre-2'-O methylation of the substrate RNA. Amino acid substitutions in the C terminus of L that prevent all cap methylation in recombinant vesicular stomatitis virus partially retain the ability to G-N-7 methylate a pre-2'-O-methylated RNA, uncoupling the effect of substitutions in the C terminus of the L protein on the two methylations. The 2'-O and G-N-7 methylase activities act specifically on RNA substrates that contain the conserved elements of a vesicular stomatitis virus mRNA start at the 5' terminus
physiological function
-
enzyme functions for both 2'-O and G-N-7 methylations during RNA cap formation. VSV L typically modifies the 2'-O position of the cap prior to the G-N-7 position and G-N-7 methylation is diminished by pre-2'-O methylation of the substrate RNA. Amino acid substitutions in the C terminus of L that prevent all cap methylation in recombinant vesicular stomatitis virus partially retain the ability to G-N-7 methylate a pre-2'-O-methylated RNA, uncoupling the effect of substitutions in the C terminus of the L protein on the two methylations. The 2'-O and G-N-7 methylase activities act specifically on RNA substrates that contain the conserved elements of a vesicular stomatitis virus mRNA start at the 5' terminus
-