2.1.1.375: NNS virus cap methyltransferase
This is an abbreviated version!
For detailed information about NNS virus cap methyltransferase, go to the full flat file.
Word Map on EC 2.1.1.375
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2.1.1.375
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stomatitis
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vesicular
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rna-dependent
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polyadenylation
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non-segmented
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unconventional
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negative-strand
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gdp
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guanylyltransferase
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rhabdoviruses
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methylase
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parainfluenza
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nucleocapsids
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mononegavirales
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polyribonucleotidyltransferase
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ppprna
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rhabdoviridae
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phosphoprotein
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guanine-n-7
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prntase
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stock
- 2.1.1.375
-
stomatitis
-
vesicular
-
rna-dependent
-
polyadenylation
-
non-segmented
-
unconventional
-
negative-strand
- gdp
-
guanylyltransferase
-
rhabdoviruses
-
methylase
-
parainfluenza
-
nucleocapsids
-
mononegavirales
-
polyribonucleotidyltransferase
- ppprna
-
rhabdoviridae
- phosphoprotein
-
guanine-n-7
- prntase
-
stock
Reaction
2 S-adenosyl-L-methionine
+
Synonyms
RNA-directed RNA polymerase L, VSV L
ECTree
2.1.1.375 NNS virus cap methyltransferaseAdvanced search results
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results (Engineering
Engineering on EC 2.1.1.375 - NNS virus cap methyltransferase
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PROTEIN VARIANTS 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
D1762A
D1762E
mutant is able to form plaques at 31°C in Vero cells with significantly reduced titers at 24 hr compared to wild-type
D1762G
mutant is able to form plaques at 31°C in Vero cells with significantly reduced titers at 24 hr compared to wild-type
D1762N
mutant is able to form plaques at 31°C in Vero cells with significantly reduced titers at 24 hr compared to wild-type
E1833Q
G1670A
mice inoculated with G1670A, which is defective only in G-N-7 methylation, are attenuated in vivo yet retain a low level of virulence
G1672A
G1672P
mutant is able to form plaques at 31°C in Vero cells
G1674P
mutant is able to form plaques at 31°C in Vero cells, but not at 39°C
G1675P
mutant is able to form plaques at 31°C in Vero cells, but not at 39°C
G4A
mutant virus is completely defective in both G-N-7 and 2'-O methylation, exhibits low virulence in mice despite productive viral replication is not detected in lung and brain
K1651A
K1795A
L1716T
mutant is able to form plaques at 31°C in Vero cells and displays a pronounced growth restriction at 39°C
L1716Y
mutant is able to form plaques at 31°C in Vero cells, but not at 39°C
D1762A
E1833Q
G1672A
G4A
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mutant virus is completely defective in both G-N-7 and 2'-O methylation, exhibits low virulence in mice despite productive viral replication is not detected in lung and brain
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K1651A
K1795A
D1762A
defective in both G-N-7 and 2'-O methylation, and highly attenuated in mice. Mutant virus elicits a high level of neutralizing antibody and provides full protection against challenge with the virulent VSV
D1762A
mutation inhibits both 2'-O and G-N-7 methylations
D1762A
mutation inhibits both 2'-O and G-N-7 methylations. When the RNA substrate is premethylated at the 2'-O position, G-N-7 methylation is restored to between 7 and 16%, compared with 50% for wild-type L
E1833Q
defective in both G-N-7 and 2'-O methylation, and highly attenuated in mice. Mutant virus elicits a high level of neutralizing antibody and provides full protection against challenge with the virulent VSV
E1833Q
mutation inhibits both 2'-O and G-N-7 methylations
E1833Q
mutation inhibits both 2'-O and G-N-7 methylations. When the RNA substrate is premethylated at the 2'-O position, G-N-7 methylation is restored to between 7 and 16%, compared with 50% for wild-type L
G1672A
mice inoculated with G1672A, which is defective only in G-N-7 methylation, are attenuated in vivo yet retain a low level of virulence
G1672A
mutant is able to form plaques at 31°C in Vero cells
K1651A
defective in both G-N-7 and 2'-O methylation, and highly attenuated in mice. Mutant virus elicits a high level of neutralizing antibody and provides full protection against challenge with the virulent VSV
K1651A
mutation inhibits both 2'-O and G-N-7 methylations
K1651A
mutation inhibits both 2'-O and G-N-7 methylations. When the RNA substrate is premethylated at the 2'-O position, G-N-7 methylation is restored to between 7 and 16%, compared with 50% for wild-type L
K1795A
mutation inhibits both 2'-O and G-N-7 methylations
K1795A
mutation inhibits both 2'-O and G-N-7 methylations. When the RNA substrate is premethylated at the 2'-O position, G-N-7 methylation is restored to between 7 and 16%, compared with 50% for wild-type L
D1762A
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mutation inhibits both 2'-O and G-N-7 methylations
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D1762A
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defective in both G-N-7 and 2'-O methylation, and highly attenuated in mice. Mutant virus elicits a high level of neutralizing antibody and provides full protection against challenge with the virulent VSV
-
D1762A
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mutation inhibits both 2'-O and G-N-7 methylations. When the RNA substrate is premethylated at the 2'-O position, G-N-7 methylation is restored to between 7 and 16%, compared with 50% for wild-type L
-
E1833Q
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mutation inhibits both 2'-O and G-N-7 methylations
-
E1833Q
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defective in both G-N-7 and 2'-O methylation, and highly attenuated in mice. Mutant virus elicits a high level of neutralizing antibody and provides full protection against challenge with the virulent VSV
-
E1833Q
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mutation inhibits both 2'-O and G-N-7 methylations. When the RNA substrate is premethylated at the 2'-O position, G-N-7 methylation is restored to between 7 and 16%, compared with 50% for wild-type L
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G1672A
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mice inoculated with G1672A, which is defective only in G-N-7 methylation, are attenuated in vivo yet retain a low level of virulence
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G1672A
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mutant is able to form plaques at 31°C in Vero cells
-
K1651A
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mutation inhibits both 2'-O and G-N-7 methylations
-
K1651A
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defective in both G-N-7 and 2'-O methylation, and highly attenuated in mice. Mutant virus elicits a high level of neutralizing antibody and provides full protection against challenge with the virulent VSV
-
K1651A
-
mutation inhibits both 2'-O and G-N-7 methylations. When the RNA substrate is premethylated at the 2'-O position, G-N-7 methylation is restored to between 7 and 16%, compared with 50% for wild-type L
-
K1795A
-
mutation inhibits both 2'-O and G-N-7 methylations
-
K1795A
-
mutation inhibits both 2'-O and G-N-7 methylations. When the RNA substrate is premethylated at the 2'-O position, G-N-7 methylation is restored to between 7 and 16%, compared with 50% for wild-type L
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