2.1.1.373: 2-hydroxy-4-(methylsulfanyl)butanoate S-methyltransferase

This is an abbreviated version!
For detailed information about 2-hydroxy-4-(methylsulfanyl)butanoate S-methyltransferase, go to the full flat file.

Reaction

Synonyms

dsyB, methylthiohydroxybutryate methyltransferase, methylthiohydroxybutyrate methyltransferase, methylthiohydroxybutyrate S-methyltransferase, MMT, MTHB methyltransferase, MTHB S-methyltransferase, MTHB-methyltransferase, SIAM614_21095, Tp23128, TpMT2, XP_002291473

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.373 2-hydroxy-4-(methylsulfanyl)butanoate S-methyltransferase

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Results	in table
2	AA Sequence
1	Cloned(Commentary)
9	Expression
44	General Information
3	Inhibitors
2	kcat/KM [mM/s]
6	KM Value [mM]
6	Localization
1	Molecular Weight [Da]
20	Natural Substrates/ Products (Substrates)
28	Organism
1	Pathway
2	pH Optimum
3	Purification (Commentary)
1	Reaction
28	Reference
30	Substrates and Products (Substrate)
2	Subunits
67	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
2	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 2.1.1.373 - 2-hydroxy-4-(methylsulfanyl)butanoate S-methyltransferase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

S-adenosyl-L-methionine + (2R)-2-hydroxy-4-(methylsulfanyl)butanoate

S-adenosyl-L-homocysteine + (2R)-4-(dimethylsulfaniumyl)-2-hydroxybutanoate

29 entries

additional information

?

-

Ulva intestinalis

-

no substrates: 3-methylthiopropionate, 3-methylthiopropylamine, D/L-methionine, L-S-methylcysteine

759975

-

-

-

S-adenosyl-L-methionine + (2R)-2-hydroxy-4-(methylsulfanyl)butanoate

S-adenosyl-L-homocysteine + (2R)-4-(dimethylsulfaniumyl)-2-hydroxybutanoate

Acropora cervicornis

-

the enzyme catalyses the key step of dimethylsulfoniopropionate biosynthesis in many phytoplankton

759840

-

-

?

S-adenosyl-L-methionine + (2R)-2-hydroxy-4-(methylsulfanyl)butanoate

S-adenosyl-L-homocysteine + (2R)-4-(dimethylsulfaniumyl)-2-hydroxybutanoate

Acropora cervicornis CCMP1771

-

the enzyme catalyses the key step of dimethylsulfoniopropionate biosynthesis in many phytoplankton

759840

-

-

?

S-adenosyl-L-methionine + (2R)-2-hydroxy-4-(methylsulfanyl)butanoate

S-adenosyl-L-homocysteine + (2R)-4-(dimethylsulfaniumyl)-2-hydroxybutanoate

Alexandrium tamarense

-

the enzyme catalyses the key step of dimethylsulfoniopropionate biosynthesis in many phytoplankton

759840

-

-

?

S-adenosyl-L-methionine + (2R)-2-hydroxy-4-(methylsulfanyl)butanoate

S-adenosyl-L-homocysteine + (2R)-4-(dimethylsulfaniumyl)-2-hydroxybutanoate

Alexandrium tamarense CCMP1771

-

the enzyme catalyses the key step of dimethylsulfoniopropionate biosynthesis in many phytoplankton

759840

-

-

?

S-adenosyl-L-methionine + (2R)-2-hydroxy-4-(methylsulfanyl)butanoate

S-adenosyl-L-homocysteine + (2R)-4-(dimethylsulfaniumyl)-2-hydroxybutanoate

bacterium

-

-

759736

-

-

?

S-adenosyl-L-methionine + (2R)-2-hydroxy-4-(methylsulfanyl)butanoate

S-adenosyl-L-homocysteine + (2R)-4-(dimethylsulfaniumyl)-2-hydroxybutanoate

bacterium

-

the enzyme is involved in biosynthesis of dimethylsulfoniopropionate

759736

-

-

?

S-adenosyl-L-methionine + (2R)-2-hydroxy-4-(methylsulfanyl)butanoate

S-adenosyl-L-homocysteine + (2R)-4-(dimethylsulfaniumyl)-2-hydroxybutanoate

Chrysochromulina tobinii

-

the enzyme catalyses the key step of dimethylsulfoniopropionate biosynthesis in many phytoplankton

759840

-

-

?

S-adenosyl-L-methionine + (2R)-2-hydroxy-4-(methylsulfanyl)butanoate

S-adenosyl-L-homocysteine + (2R)-4-(dimethylsulfaniumyl)-2-hydroxybutanoate

Chrysochromulina tobinii CCMP291

-

the enzyme catalyses the key step of dimethylsulfoniopropionate biosynthesis in many phytoplankton

759840

-

-

?

S-adenosyl-L-methionine + (2R)-2-hydroxy-4-(methylsulfanyl)butanoate

S-adenosyl-L-homocysteine + (2R)-4-(dimethylsulfaniumyl)-2-hydroxybutanoate

Fragilariopsis cylindrus

-

the enzyme catalyses the key step of dimethylsulfoniopropionate biosynthesis in many phytoplankton

759840

-

-

?

S-adenosyl-L-methionine + (2R)-2-hydroxy-4-(methylsulfanyl)butanoate

S-adenosyl-L-homocysteine + (2R)-4-(dimethylsulfaniumyl)-2-hydroxybutanoate

Fragilariopsis cylindrus CCMP1102

-

the enzyme catalyses the key step of dimethylsulfoniopropionate biosynthesis in many phytoplankton

759840

-

-

?

S-adenosyl-L-methionine + (2R)-2-hydroxy-4-(methylsulfanyl)butanoate

S-adenosyl-L-homocysteine + (2R)-4-(dimethylsulfaniumyl)-2-hydroxybutanoate

Lingulodinium polyedra

-

the enzyme catalyses the key step of dimethylsulfoniopropionate biosynthesis in many phytoplankton

759840

-

-

?

S-adenosyl-L-methionine + (2R)-2-hydroxy-4-(methylsulfanyl)butanoate

S-adenosyl-L-homocysteine + (2R)-4-(dimethylsulfaniumyl)-2-hydroxybutanoate

Lingulodinium polyedra CCMP1936

-

the enzyme catalyses the key step of dimethylsulfoniopropionate biosynthesis in many phytoplankton

759840

-

-

?

S-adenosyl-L-methionine + (2R)-2-hydroxy-4-(methylsulfanyl)butanoate

S-adenosyl-L-homocysteine + (2R)-4-(dimethylsulfaniumyl)-2-hydroxybutanoate

Prymnesium parvum

-

the enzyme catalyses the key step of dimethylsulfoniopropionate biosynthesis in many phytoplankton

759840

-

-

?

S-adenosyl-L-methionine + (2R)-2-hydroxy-4-(methylsulfanyl)butanoate

S-adenosyl-L-homocysteine + (2R)-4-(dimethylsulfaniumyl)-2-hydroxybutanoate

Prymnesium parvum

-

the enzyme shows no detectable methyltransferase activity with other potential substrates including methionine, 4-methylthio-2-oxobutyrate and methylmercaptopropionate

759840

-

-

?

S-adenosyl-L-methionine + (2R)-2-hydroxy-4-(methylsulfanyl)butanoate

S-adenosyl-L-homocysteine + (2R)-4-(dimethylsulfaniumyl)-2-hydroxybutanoate

Prymnesium parvum CCAP941

-

the enzyme catalyses the key step of dimethylsulfoniopropionate biosynthesis in many phytoplankton

759840

-

-

?

S-adenosyl-L-methionine + (2R)-2-hydroxy-4-(methylsulfanyl)butanoate

S-adenosyl-L-homocysteine + (2R)-4-(dimethylsulfaniumyl)-2-hydroxybutanoate

Prymnesium parvum CCAP941

-

the enzyme shows no detectable methyltransferase activity with other potential substrates including methionine, 4-methylthio-2-oxobutyrate and methylmercaptopropionate

759840

-

-

?

S-adenosyl-L-methionine + (2R)-2-hydroxy-4-(methylsulfanyl)butanoate

S-adenosyl-L-homocysteine + (2R)-4-(dimethylsulfaniumyl)-2-hydroxybutanoate

Prymnesium parvum CCAP946/1B

-

the enzyme catalyses the key step of dimethylsulfoniopropionate biosynthesis in many phytoplankton

759840

-

-

?

S-adenosyl-L-methionine + (2R)-2-hydroxy-4-(methylsulfanyl)butanoate

S-adenosyl-L-homocysteine + (2R)-4-(dimethylsulfaniumyl)-2-hydroxybutanoate

Prymnesium parvum CCAP946/1B

-

the enzyme shows no detectable methyltransferase activity with other potential substrates including methionine, 4-methylthio-2-oxobutyrate and methylmercaptopropionate

759840

-

-

?

S-adenosyl-L-methionine + (2R)-2-hydroxy-4-(methylsulfanyl)butanoate

S-adenosyl-L-homocysteine + (2R)-4-(dimethylsulfaniumyl)-2-hydroxybutanoate

Symbiodinium microadriaticum

-

the enzyme catalyses the key step of dimethylsulfoniopropionate biosynthesis in many phytoplankton

759840

-

-

?

S-adenosyl-L-methionine + (2R)-2-hydroxy-4-(methylsulfanyl)butanoate

S-adenosyl-L-homocysteine + (2R)-4-(dimethylsulfaniumyl)-2-hydroxybutanoate

Symbiodinium microadriaticum CCMP2467

-

the enzyme catalyses the key step of dimethylsulfoniopropionate biosynthesis in many phytoplankton

759840

-

-

?

S-adenosyl-L-methionine + (2R)-2-hydroxy-4-(methylsulfanyl)butanoate

S-adenosyl-L-homocysteine + (2R)-4-(dimethylsulfaniumyl)-2-hydroxybutanoate

Thalassiosira pseudonana

B8C5X1

-

758701

-

-

?

S-adenosyl-L-methionine + (2R)-2-hydroxy-4-(methylsulfanyl)butanoate

S-adenosyl-L-homocysteine + (2R)-4-(dimethylsulfaniumyl)-2-hydroxybutanoate

Thalassiosira pseudonana

B8C5X1

the enzyme catalyses the key step of dimethylsulfoniopropionate biosynthesis. Dimethylsulfoniopropionate plays a pivotal role in the marine sulfur cycle

758701

-

-

?

S-adenosyl-L-methionine + (2R)-2-hydroxy-4-(methylsulfanyl)butanoate

S-adenosyl-L-homocysteine + (2R)-4-(dimethylsulfaniumyl)-2-hydroxybutanoate

Thalassiosira pseudonana CCMP1335

B8C5X1

-

758701

-

-

?

S-adenosyl-L-methionine + (2R)-2-hydroxy-4-(methylsulfanyl)butanoate

S-adenosyl-L-homocysteine + (2R)-4-(dimethylsulfaniumyl)-2-hydroxybutanoate

Thalassiosira pseudonana CCMP1335

B8C5X1

the enzyme catalyses the key step of dimethylsulfoniopropionate biosynthesis. Dimethylsulfoniopropionate plays a pivotal role in the marine sulfur cycle

758701

-

-

?

S-adenosyl-L-methionine + (2R)-2-hydroxy-4-(methylsulfanyl)butanoate

S-adenosyl-L-homocysteine + (2R)-4-(dimethylsulfaniumyl)-2-hydroxybutanoate

Ulva intestinalis

-

enzyme is specific for (2R)-enantiomer of 2-hydroxy-4-(methylsulfanyl)butanoate

759975

-

-

?

S-adenosyl-L-methionine + (2R)-2-hydroxy-4-(methylsulfanyl)butanoate

S-adenosyl-L-homocysteine + (2R)-4-(dimethylsulfaniumyl)-2-hydroxybutanoate

Ulva pertusa

-

-

759654

-

-

?

S-adenosyl-L-methionine + (2R)-2-hydroxy-4-(methylsulfanyl)butanoate

S-adenosyl-L-homocysteine + (2R)-4-(dimethylsulfaniumyl)-2-hydroxybutanoate

Ulva pertusa

-

the enzyme is involved in biosynthesis of dimethylsulfoniopropionate from methionine

759654

-

-

?

S-adenosyl-L-methionine + (2R)-2-hydroxy-4-(methylsulfanyl)butanoate

S-adenosyl-L-homocysteine + (2R)-4-(dimethylsulfaniumyl)-2-hydroxybutanoate

uncultured bacterium

-

-

759828

-

-

?

S-adenosyl-L-methionine + (2R)-2-hydroxy-4-(methylsulfanyl)butanoate

S-adenosyl-L-homocysteine + (2R)-4-(dimethylsulfaniumyl)-2-hydroxybutanoate

uncultured bacterium

-

the enzyme is involved in biosynthesis of dimethylsulfoniopropionate

759828

-

-

?