1.14.20.15: L-threonyl-[L-threonyl-carrier protein] 4-chlorinase

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For detailed information about L-threonyl-[L-threonyl-carrier protein] 4-chlorinase, go to the full flat file.

Reaction

Synonyms

aliphatic halogenase, SyrB2, syringomycin biosynthesis enzyme 2, Thr3

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.20 With 2-oxoglutarate as one donor, and the other dehydrogenated

                1.14.20.15 L-threonyl-[L-threonyl-carrier protein] 4-chlorinase

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Results	in table
2	AA Sequence
4	Cloned(Commentary)
1	Crystallization (Commentary)
15	General Information
1	General Stability
8	Metals/Ions
6	Natural Substrates/ Products (Substrates)
78	Organism
1	pH Optimum
33	Protein Variants
2	Purification (Commentary)
1	Reaction
22	Reference
25	Substrates and Products (Substrate)
19	Synonyms
1	Systematic Name

Natural Substrates Products

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Natural Substrates Products on EC 1.14.20.15 - L-threonyl-[L-threonyl-carrier protein] 4-chlorinase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

L-threonyl-[L-threonyl-carrier protein SyrB1] + 2-oxoglutarate + O2 + Cl-

4-chloro-L-threonyl-[L-threonyl-carrier protein SyrB1] + succinate + CO2 + H2O

3 entries

additional information

?

-

2 entries

L-threonyl-[L-threonyl-carrier protein SyrB1] + 2-oxoglutarate + O2 + Cl-

4-chloro-L-threonyl-[L-threonyl-carrier protein SyrB1] + succinate + CO2 + H2O

Pseudomonas syringae pv. syringae

Q9RBY6

the enzyme participates in syringomycin E biosynthesis

747063, 749157

-

-

?

L-threonyl-[L-threonyl-carrier protein SyrB1] + 2-oxoglutarate + O2 + Cl-

4-chloro-L-threonyl-[L-threonyl-carrier protein SyrB1] + succinate + CO2 + H2O

Pseudomonas syringae pv. syringae B301D

Q9RBY6

the enzyme participates in syringomycin E biosynthesis

747063, 749157

-

-

?

L-threonyl-[L-threonyl-carrier protein SyrB1] + 2-oxoglutarate + O2 + Cl-

4-chloro-L-threonyl-[L-threonyl-carrier protein SyrB1] + succinate + CO2 + H2O

Pseudomonas syringae pv. syringae B301D

-

the enzyme participates in syringomycin E biosynthesis

749157

-

-

?

additional information

?

-

Pseudomonas syringae

-

the enzyme catalyzes chlorination of the C4 position of L-threonine appended via a thioester linkage to the phosphopantetheine arm of the companion aminoacyl carrier protein, SyrB1. The native substrate of SyrB2, Thr, is almost exclusively chlorinated, although non-native substrates undergo hydroxylation as well as chlorination. SyrB2 represents an intriguing case in which two different reaction outcomes catalyzed by this enzyme family (hydroxylation and halogenation) are observed

734033

-

-

?

additional information

?

-

Pseudomonas syringae B301D

-

the enzyme catalyzes chlorination of the C4 position of L-threonine appended via a thioester linkage to the phosphopantetheine arm of the companion aminoacyl carrier protein, SyrB1. The native substrate of SyrB2, Thr, is almost exclusively chlorinated, although non-native substrates undergo hydroxylation as well as chlorination. SyrB2 represents an intriguing case in which two different reaction outcomes catalyzed by this enzyme family (hydroxylation and halogenation) are observed

734033

-

-

?