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1.14.20.15: L-threonyl-[L-threonyl-carrier protein] 4-chlorinase

This is an abbreviated version!
For detailed information about L-threonyl-[L-threonyl-carrier protein] 4-chlorinase, go to the full flat file.

Word Map on EC 1.14.20.15

Reaction

an L-threonyl-[L-threonyl-carrier protein]
+
2-oxoglutarate
 +
O2
 +
Cl-
=
a 4-chloro-L-threonyl-[L-threonyl-carrier protein]
 +
succinate
 +
CO2
 +
H2O

Synonyms

aliphatic halogenase, SyrB2, syringomycin biosynthesis enzyme 2, Thr3

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.20 With 2-oxoglutarate as one donor, and the other dehydrogenated
                1.14.20.15 L-threonyl-[L-threonyl-carrier protein] 4-chlorinase

Metals Ions

Metals Ions on EC 1.14.20.15 - L-threonyl-[L-threonyl-carrier protein] 4-chlorinase

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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Iron
the enzyme employs an Fe(IV)-oxo species to achieve selective C-H halogenation of L-threonine. Combined quantum mechanical/molecular mechanical (QM/MM) calculations show the presence of three Cl-Fe(IV)-oxo isomers which interconvert. The one having its oxo ligand pointing toward the target C-H bond is active during the hydrogen atom abstraction (H-abstraction) process. The fate of the formed Cl-FeIII-OH/R radical intermediate is determined by a hydrogenbonding interaction between the Arg254 residue and the OH ligand of Cl-Fe(III)-OH