1.14.19.60: 7-chloro-L-tryptophan 6-halogenase

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For detailed information about 7-chloro-L-tryptophan 6-halogenase, go to the full flat file.

Reaction

Synonyms

KtzR

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.19 With oxidation of a pair of donors resulting in the reduction of O₂ to two molecules of water

                1.14.19.60 7-chloro-L-tryptophan 6-halogenase

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Results	in table
1	AA Sequence
1	Cloned(Commentary)
1	General Information
2	kcat/KM [mM/s]
2	KM Value [mM]
1	Natural Substrates/ Products (Substrates)
1	Organism
1	pH Optimum
1	Purification (Commentary)
1	Reaction
1	Reference
4	Substrates and Products (Substrate)
1	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
2	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 1.14.19.60 - 7-chloro-L-tryptophan 6-halogenase

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SYSTEMATIC NAME

IUBMB Comments

7-chloro-L-tryptophan:FADH2 oxidoreductase (6-halogenating)

An FAD-dependent halogenase. The enzyme, characterized from the bacterium Kutzneria sp. 744, works in tandem with EC 1.14.19.9, tryptophan 7-halogenase, (ktzQ) to generate 6,7-dichloro-L-tryptophan, which is incorporated as a pyrroloindoline in the kutznerides family of natural products. It has a 120-fold preference for 7-chloro-L-tryptophan over L-tryptophan as substrate.