1.14.19.60: 7-chloro-L-tryptophan 6-halogenase

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For detailed information about 7-chloro-L-tryptophan 6-halogenase, go to the full flat file.

+ 2 H2O

KtzR

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Results	in table
1	AA Sequence
1	Cloned(Commentary)
1	General Information
2	kcat/KM [mM/s]
2	KM Value [mM]
1	Natural Substrates/ Products (Substrates)
1	Organism
1	pH Optimum
1	Purification (Commentary)
1	Reaction
1	Reference
4	Substrates and Products (Substrate)
1	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
2	Turnover Number [1/s]

Substrates Products on EC 1.14.19.60 - 7-chloro-L-tryptophan 6-halogenase

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7-chloro-L-tryptophan + FADH2 + Cl- + O2 + H+

6,7-dichloro-L-tryptophan + FAD + 2 H2O

L-tryptophan + FADH2 + Cl- + O2 + H+

6-chloro-L-tryptophan + FAD + 2 H2O

kcat/Km for the halogenation of L-tryptophan is less than 1% compared to the value for the halogenation 7-chloro-L-tryptophan

additional information

KtzR is not active for introduction of chloride to piperazic acid or gamma,delta-dehydropiperazic acid