EC Number   |
General Information |
Reference |
|---|
   3.4.21.59 | malfunction |
tryptase deficiency results in defective proteolytic modification of core histones |
732170 |
| 3.4.21.59 | physiological function |
activates isolated adult cardiac fibroblasts (Mus musculus) via protease activated receptor-2 (PAR-2) |
717896 |
| 3.4.21.59 | physiological function |
an essential mast cell-restricted mediator in chemically induced colitis, acts upstream of many of the factors implicated in inflammatory bowel disease |
718326 |
| 3.4.21.59 | physiological function |
angiogenic activity (shown in a chick embryo chorioallantoic membrane in vivo assay) |
717677 |
| 3.4.21.59 | physiological function |
can induce microvascular leakage via prostaglandins in a mast cell-independent manner and may contribute to the development of basophil-mediated inflammatory responses |
717203 |
| 3.4.21.59 | physiological function |
mast cell tryptase induces eosinophil recruitment in the pleural cavity of mice via proteinase-activated receptor 2 |
731913 |
| 3.4.21.59 | physiological function |
mast cell tryptase induces microglia activation via protease-activated receptor 2-mitogen-activated protein kinase-nuclear factor kappa B signaling pathway, which will contribute to the development of microglia-mediated inflammation in brain |
731629 |
| 3.4.21.59 | physiological function |
mast cell-derived tryptase potentiates cancer-associated fibroblast-induced morphology changes of prostate epithelia indirectly via the tumour microenvironment |
752908 |
| 3.4.21.59 | physiological function |
the enzyme is an important mediator of the allergic inflammatory responses in asthma |
754178 |
| 3.4.21.59 | physiological function |
the enzyme is involved in angiogenesis after its release from activated mast cell granules. The enzyme is released with histamine from human skin mast cells in acute and chronic in vivo responses to allergens. The enzyme is a potent activator of fibroblast migration and proliferation, and collagen synthesis, stimulating tissue repair in wound healing and fibrosis. The enzyme tryptase plays an important role in host defense, linking adaptive and innate immunity |
753506 |
