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Ac-Arg-Asn-Lys-5-amino-2-nitrobenzoylamide + H2O
?
-
chromogenic substrate
-
-
?
Ac-Ile-Arg-Asn-Lys-5-amino-2-nitrobenzoylamide + H2O
?
-
chromogenic substrate
-
-
?
Ac-PANKAAC + H2O
Ac-PANK + Ala-Ala-Cys
-
betaI and betaII tryptase
-
?
Ac-PRNKAAC + H2O
Ac-PRNK + Ala-Ala-Cys
-
betaI and betaII tryptase
-
?
Ac-PRNRAAC + H2O
Ac-PRNR + Ala-Ala-Cys
-
betaI and betaII tryptase
-
?
Ac-Pro-Ile-Arg-Asn-Lys-5-amino-2-nitrobenzoylamide + H2O
?
-
chromogenic substrate, best peptide substrate
-
-
?
Ac-PRTKAAC + H2O
Ac-PRTK + Ala-Ala-Cys
-
betaI and betaII tryptase
-
?
Ac-Ser-Ile-Gln-Ser-Arg-4-methyl-coumarin 7-amide + H2O
?
-
synthetic substrate, relative activity 51.2%
-
?
Ala-Ala-Pro-Ile-Arg-Asn-Lys-5-amino-2-nitrobenzoylamide + H2O
?
-
chromogenic substrate, high activity
-
-
?
Ala-Pro-Ile-Arg-Asn-Lys-5-amino-2-nitrobenzoylamide + H2O
?
-
chromogenic substrate
-
-
?
alpha2-antiplasmin + H2O
?
-
substrate binding and interaction with the enzyme, overview
-
-
?
Arg-Asn-Lys-5-amino-2-nitrobenzoylamide + H2O
?
-
chromogenic substrate
-
-
?
benzoyl-Arg 4-nitroanilide + H2O
benzoyl-Arg + 4-nitroaniline
-
-
-
-
?
Benzoyl-L-Lys-Gly-L-Arg 4-nitroanilide + H2O
Benzoyl-L-Lys-Gly-L-Arg + 4-nitroaniline
benzoyl-L-Phe-L-Val-L-Arg-4-nitroanilide + H2O
benzoyl-L-Phe-L-Val-L-Arg + 4-nitroaniline
-
-
-
-
?
Benzyloxycarbonyl-Ala-Ala-Lys 4-methoxy-2-naphthylamide + H2O
?
-
-
-
-
?
Benzyloxycarbonyl-Ala-Arg-Arg 4-methylcoumarin 7-amide + H2O
Benzyloxycarbonyl-Ala-Arg-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
Benzyloxycarbonyl-Arg 4-methylcoumarin 7-amide + H2O
Benzyloxycarbonyl-Arg + 7-amino-4-methylcoumarine
-
-
-
-
?
Benzyloxycarbonyl-Arg 4-nitroanilide + H2O
Benzyloxycarbonyl-Arg + 4-nitroaniline
-
-
-
?
Benzyloxycarbonyl-Glu-Phe-Arg 4-nitroanilide + H2O
Benzyloxycarbonyl-Glu-Phe-Arg + 4-nitroaniline
-
best substrate for lung enzyme
-
-
?
Benzyloxycarbonyl-Gly-Arg 4-trifluoromethylcoumarin 7-amide + H2O
Benzyloxycarbonyl-Gly-Arg + 7-amino-4-trifluoromethylcoumarin
-
-
-
-
?
Benzyloxycarbonyl-Gly-Pro-Arg 4-nitroanilide + H2O
Benzyloxycarbonyl-Gly-Pro-Arg + 4-nitroaniline
-
-
-
-
?
Benzyloxycarbonyl-L-Ala-L-Arg-L-Arg 4-methylcoumarin 7-amide + H2O
Benzyloxycarbonyl-L-Ala-L-Arg-L-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
benzyloxycarbonyl-L-Ala-L-Leu-L-Lys-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-L-Ala-L-Leu-L-Lys + 7-amino-4-methylcoumarin
-
-
-
-
?
Benzyloxycarbonyl-L-Ala-L-Lys-L-Arg 4-methylcoumarin 7-amide + H2O
Benzyloxycarbonyl-L-Ala-L-Lys-L-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
Benzyloxycarbonyl-L-Ala-L-Lys-L-Lys 4-methylcoumarin 7-amide + H2O
Benzyloxycarbonyl-L-Ala-L-Lys-L-Lys + 7-amino-4-methylcoumarin
-
-
-
-
?
Benzyloxycarbonyl-Lys-Arg 4-trifluoromethylcoumarin 7-amide + H2O
Benzyloxycarbonyl-Lys-Arg + 7-amino-4-trifluoromethylcoumarin
-
-
-
-
?
Benzyloxycarbonyl-Lys-Arg-S-CH2(CH3)2 + H2O
Benzyloxycarbonyl-Lys-Arg + S-CH2(CH3)2
-
best substrate for skin enzyme
-
-
?
Boc-Phe-Ser-Arg-methyl-coumarin + H2O
?
-
synthetic substrate
-
?
bovine prothrombin + H2O
?
-
-
-
-
?
Bz-Arg-p-nitroanilide + H2O
?
-
-
-
?
complement component 3 + H2O
?
-
digestion
-
-
?
D-Ile-Pro-Arg-4-nitroanilide + H2O
D-Ile-Pro-Arg + 4-nitroaniline
-
-
-
-
?
D-Ile-Pro-Arg-p-nitroanilide + H2O
?
-
-
-
?
D-Phe-Pip-Arg-p-nitroanilide + H2O
?
-
-
-
?
D-Phe-piperocolyl-L-Arg 4-nitroanilide + H2O
D-Phe-piperocolyl-L-Arg + 4-nitroaniline
-
-
-
-
?
D-phenylalanyl-pipecolyl-L-arginine-4-nitroanilide + H2O
D-phenylalanyl-pipecolyl-L-arginine + 4-nitroaniline
D-Pro-Phe-Arg-p-nitroanilide + H2O
?
-
-
-
?
D-Val-Leu-Arg 4-methoxy-2-naphthylamide + H2O
?
-
-
-
-
?
D-Val-Leu-Arg-p-nitroanilide + H2O
?
-
-
-
?
fibrinogen + H2O
fibrin + ?
fibrinogen + H2O
fibrinogen fragments
Gelatinase + H2O
?
-
digestion of the 72000 MW form to a 62000 MW form
-
-
?
Glu-Gly-Arg-p-nitroanilide + H2O
?
-
-
-
?
Glu-Pro-Arg-p-nitroanilide + H2O
?
-
-
-
?
High-molecular mass kininogen + H2O
?
-
-
-
-
?
high-molecular-weight kininogen + H2O
?
-
-
-
-
?
histone 2B + H2O
?
-
-
-
-
?
histone 3 + H2O
?
-
-
-
-
?
human influenza virus HA + H2O
HA1 + HA2
-
-
-
?
Ile-Arg-Asn-Lys-5-amino-2-nitrobenzoylamide + H2O
?
-
chromogenic substrate
-
-
?
kininogen + H2O
?
-
-
-
-
?
L-pyroGlu-Gly-Arg 4-nitroanilide + H2O
L-pyroGlu-Gly-Arg + 4-nitroaniline
-
-
-
-
?
LL-37 + H2O
LL-37 fragments
-
the platelet-derived chemokine CXCL4 protects LL-37 from cleavage by beta-tryptase
-
-
?
MeOCO-Nle-Gly-Arg-p-nitroanilide + H2O
?
-
-
-
?
N-(p-tosyl)-Gly-Pro-Arg-4-nitroanilide + H2O
N-(p-tosyl)-Gly-Pro-Arg + 4-nitroaniline
-
-
-
?
N-(p-tosyl)-Gly-Pro-Lys-4-nitroanilide + H2O
N-(p-tosyl)-Gly-Pro-Lys + 4-nitroaniline
-
-
-
?
N-Benzoyl-Arg ethyl ester + H2O
?
-
-
-
-
?
N-benzoyl-DL-Arg-4-nitroanilide + H2O
N-benzoyl-DL-Arg + 4-nitroaniline
-
-
-
?
N-benzoyl-DL-Arg-p-nitroanilide + H2O
N-benzoyl-DL-Arg + p-nitroaniline
-
measurements of tryptase activity in sputum of chronic obstructive pulmonary disease patiens
-
-
?
N-benzoyl-DL-arginine-4-nitroanilide + H2O
N-benzoyl-DL-arginine + 4-nitroaniline
-
-
-
-
?
N-benzyloxycarbonyl-Gly-Pro-Arg-p-nitroanilide + H2O
?
-
-
-
-
?
N-Carbobenzoxy-Arg-Arg 4-methylcoumarin 7-amide + H2O
N-Carbobenzoxy-Arg-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
N-carbobenzoxy-GPR-4-nitroanilide + H2O
?
-
-
-
?
N-Carbobenzoxy-Phe-Arg 4-methylcoumarin 7-amide + H2O
N-Carbobenzoxy-Phe-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
N-p-tosyl-Gly-Pro-Arg-p-nitroanilide + H2O
?
N-p-tosyl-Gly-Pro-Arg-p-nitroanilide + H2O
N-p-tosyl-Gly-Pro-Arg + p-nitroaniline
-
-
-
-
?
N-p-tosyl-Gly-Pro-Lys-p-nitroanilide + H2O
?
N-tert-Butyloxycarbonyl-Ile-Glu-Gly-Arg 4-methylcoumarin 7-amide + H2O
N-tert-Butyloxycarbonyl-Ile-Glu-Gly-Arg + 7-amino-4-methylcoumarin
-
rapid hydrolysis by free enzyme, scarcely hydrolyzed by the enzyme associated with trypstatin
-
-
?
N-tert-Butyloxycarbonyl-Phe-Ser-Arg 4-methylcoumarin 7-amide + H2O
N-tert-Butyloxycarbonyl-Phe-Ser-Arg + 7-amino-4-methylcoumarin
N-tert-Butyloxycarbonyl-Val-Pro-Arg 4-methylcoumarin 7-amide + H2O
N-tert-Butyloxycarbonyl-Val-Pro-Arg + 7-amino-4-methylcoumarin
Nalpha-benzoyl-DL-arginine-4-nitroanilide + H2O
?
-
-
-
?
Nalpha-benzoyl-L-arginine-p-nitroanilide + H2O
?
-
-
-
?
neurotensin + H2O
?
-
-
-
-
?
Oxidized B-chain of insulin + H2O
?
-
cleavage at Arg8-Gly9-NH2, Arg8-Arg9- and Arg22-Gly23-bonds
-
-
?
plasminogen + H2O
plasmin + ?
Precursor of matrix metalloproteinase 1 + H2O
?
-
conversion of the 52000 MW precursor into a 41000 MW protein, generation of new N-termini, namely Gln80 and Val82
-
-
?
Precursor of matrix metalloproteinase 3 + H2O
?
-
conversion of the 57000 MW precursor to a 45000 MW polypeptide, N-terminal amino acid is Phe83
-
-
?
Pro-Ile-Arg-Asn-Lys-5-amino-2-nitrobenzoylamide + H2O
?
-
chromogenic substrate, best peptide substrate
-
-
?
pro-interleukin-6 + H2O
interleukin-6 + ?
-
-
-
-
?
pro-matrix metalloprotease-3 + H2O
?
-
digestion
-
-
?
pro-matrix metalloproteinase-1 + H2O
matrix metalloproteinase-1 + ?
-
-
-
-
?
pro-matrix metalloproteinase-13 + H2O
matrix metalloproteinase-13 + ?
-
-
-
-
?
pro-matrix metalloproteinase-2 + H2O
matrix metalloproteinase-2 + ?
-
-
-
-
?
pro-matrix metalloproteinase-3 + H2O
matrix metalloproteinase-3 + ?
-
-
-
-
?
pro-matrix metalloproteinase-9 + H2O
matrix metalloproteinase-9 + ?
-
-
-
-
?
pro-nerve growth factor + H2O
mature nerve growth factor and smaller fragments
-
-
analyzed by MS/MS
-
?
pro-nuclear factor-kappa B + H2O
nuclear factor-kappa B + ?
-
-
-
-
?
Pro-Phe-Arg-4-methyl-coumarin 7-amide + H2O
?
-
synthetic substrate, relative activity 3.9%
-
?
pro-proteinase-activated receptor 2 + H2O
proteinase-activated receptor 2 + ?
-
-
-
-
?
pro-tissue necrosis factor + H2O
tissue necrosis factor + ?
-
-
-
-
?
Pro-urokinase + H2O
?
-
digestion
-
-
?
protease activated receptor-2 + H2O
?
protease-activated receptor 2 + H2O
fibrin + ?
-
-
-
-
?
protease-activated receptor-2 + H2O
?
-
digestion
-
-
?
proteinase-activated receptor 2 + H2O
?
-
-
-
-
?
proteinase-activated receptor-2 + H2O
?
-
tryptase may contribute to cyclooxygenase-2 upregulation by epithelial proteinase-activated receptor-2 activation during early lip carcinogenesis
-
-
?
prothrombin + H2O
thrombin + ?
S-2288 + H2O
D-Ile-L-Pro-L-Arg + 4-nitroaniline
-
-
-
?
t-butyloxycarbonyl-Gln-Ala-Arg-4-methyl-coumarin 7-amide + H2O
?
-
synthetic substrate, relative activity 100%
-
?
t-butyloxycarbonyl-Gln-Arg-Arg-4-methyl-coumarin 7-amide + H2O
?
-
synthetic substrate, relative activity 26.0%
-
?
t-butyloxycarbonyl-Gln-Gly-Arg-4-methyl-coumarin 7-amide + H2O
?
-
synthetic substrate, relative activity 63.3%
-
?
t-butyloxycarbonyl-Glu(OBzl)-Ala-Arg-4-methyl-coumarin 7-amide + H2O
?
-
synthetic substrate, relative activity 67.3%
-
?
t-butyloxycarbonyl-Glu(OBzl)-Gly-Arg-4-methyl-coumarin 7-amide + H2O
?
-
synthetic substrate, relative activity 26.3%
-
?
t-butyloxycarbonyl-Glu-Lys-Lys-4-methyl-coumarin 7-amide + H2O
?
-
synthetic substrate, relative activity 1.6%
-
?
t-butyloxycarbonyl-Gly-Lys-Arg-4-methyl-coumarin 7-amide + H2O
?
-
synthetic substrate, relative activity 10.9%
-
?
t-butyloxycarbonyl-Ile-Glu-Gly-Arg-4-methyl-coumarin 7-amide + H2O
?
-
synthetic substrate, relative activity 3.5%
-
?
t-butyloxycarbonyl-Leu-Arg-Arg-4-methyl-coumarin 7-amide + H2O
?
-
synthetic substrate, relative activity 5.9%
-
?
t-butyloxycarbonyl-Leu-Gly-Arg-4-methyl-coumarin 7-amide + H2O
?
-
synthetic substrate, relative activity 30.0%
-
?
t-butyloxycarbonyl-Leu-Lys-Arg-4-methyl-coumarin 7-amide + H2O
?
-
synthetic substrate, relative activity 14.4%
-
?
t-butyloxycarbonyl-Phe-Ser-Arg-4-methyl-coumarin 7-amide + H2O
?
t-butyloxycarbonyl-Val-Pro-Arg-4-methyl-coumarin 7-amide + H2O
?
-
synthetic substrate, relative activity 6.1%
-
?
tert-butyloxycarbonyl-Gly-Lys-Arg 4-methylcoumarin 7-amide + H2O
tert-butyloxycarbonyl-Gly-Lys-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
TGFbeta + H2O
activated TGFbeta + ?
Tos-Gly-Pro-Arg-7-amido-4-methylcoumarin + H2O
Tos-Gly-Pro-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
Tosyl-Arg methyl ester + H2O
?
-
-
-
-
?
Tosyl-Gly-L-Pro-Arg 4-nitroanilide + H2O
Tosyl-Gly-L-Pro-Arg + 4-nitroaniline
-
-
-
?
tosyl-Gly-L-Pro-L-Arg-7-amido-4-methylcoumarin + H2O
tosyl-Gly-L-Pro-L-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
tosyl-Gly-Pro-Arg-p-nitroanilide + H2O
tosyl-Gly-Pro-Arg + p-nitroaniline
-
-
-
?
Tosyl-Gly-Pro-Lys 4-nitroanilide + H2O
Tosyl-Gly-Pro-Lys + 4-nitroaniline
-
-
-
-
?
tosyl-Gly-Pro-Lys-4-nitroanilide + H2O
tosyl-Gly-Pro-Lys + 4-nitroaniline
-
-
-
-
?
tosyl-Gly-Pro-Lys-p-nitroanilide + H2O
?
-
-
-
?
tosyl-glycine-L-proline-L-arginine-4-nitroanilide + H2O
tosyl-glycine-L-proline-L-arginine + 4-nitroaniline
-
-
-
-
?
tosyl-GPK-4-nitroanilide + H2O
?
-
-
-
?
tosyl-GPR-4-nitroanilide + H2O
?
-
-
-
?
Type IV collagen + H2O
?
-
-
-
-
?
urokinase plasminogen activator + H2O
?
-
-
-
-
?
Vasoactive intestinal peptide + H2O
?
-
-
-
-
?
Z-D-Arg-Gly-Arg-p-nitroanilide + H2O
?
-
-
-
?
[Arg8]vasopressin + H2O
?
-
-
-
-
?
additional information
?
-
Benzoyl-L-Lys-Gly-L-Arg 4-nitroanilide + H2O
Benzoyl-L-Lys-Gly-L-Arg + 4-nitroaniline
-
best of the substrates screened
-
-
?
Benzoyl-L-Lys-Gly-L-Arg 4-nitroanilide + H2O
Benzoyl-L-Lys-Gly-L-Arg + 4-nitroaniline
-
best of the substrates screened
-
-
?
D-phenylalanyl-pipecolyl-L-arginine-4-nitroanilide + H2O
D-phenylalanyl-pipecolyl-L-arginine + 4-nitroaniline
-
-
-
-
?
D-phenylalanyl-pipecolyl-L-arginine-4-nitroanilide + H2O
D-phenylalanyl-pipecolyl-L-arginine + 4-nitroaniline
-
-
-
-
?
Fibrinogen + H2O
?
-
-
-
-
?
Fibrinogen + H2O
?
-
digestion
-
-
?
fibrinogen + H2O
fibrin + ?
-
-
-
?
fibrinogen + H2O
fibrin + ?
-
-
-
-
?
fibrinogen + H2O
fibrin + ?
-
-
-
?
fibrinogen + H2O
fibrin + ?
-
-
-
-
?
fibrinogen + H2O
fibrinogen fragments
-
-
-
?
fibrinogen + H2O
fibrinogen fragments
-
-
-
?
fibrinogen + H2O
fibrinogen fragments
-
-
-
?
Fibronectin + H2O
?
-
-
-
-
?
Fibronectin + H2O
?
-
digestion
-
-
?
N-p-tosyl-Gly-Pro-Arg-p-nitroanilide + H2O
?
-
-
-
?
N-p-tosyl-Gly-Pro-Arg-p-nitroanilide + H2O
?
-
synthetic peptide substrate, mutant enzyme, expressed in insect cells
-
?
N-p-tosyl-Gly-Pro-Lys-p-nitroanilide + H2O
?
-
-
-
?
N-p-tosyl-Gly-Pro-Lys-p-nitroanilide + H2O
?
-
-
-
?
N-p-tosyl-Gly-Pro-Lys-p-nitroanilide + H2O
?
-
synthetic peptide substrate
-
?
N-p-tosyl-Gly-Pro-Lys-p-nitroanilide + H2O
?
-
-
-
?
N-tert-Butyloxycarbonyl-Phe-Ser-Arg 4-methylcoumarin 7-amide + H2O
N-tert-Butyloxycarbonyl-Phe-Ser-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
N-tert-Butyloxycarbonyl-Phe-Ser-Arg 4-methylcoumarin 7-amide + H2O
N-tert-Butyloxycarbonyl-Phe-Ser-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
N-tert-Butyloxycarbonyl-Val-Pro-Arg 4-methylcoumarin 7-amide + H2O
N-tert-Butyloxycarbonyl-Val-Pro-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
N-tert-Butyloxycarbonyl-Val-Pro-Arg 4-methylcoumarin 7-amide + H2O
N-tert-Butyloxycarbonyl-Val-Pro-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
plasminogen + H2O
plasmin + ?
-
-
-
-
?
plasminogen + H2O
plasmin + ?
-
-
-
-
?
protease activated receptor-2 + H2O
?
-
-
-
-
?
protease activated receptor-2 + H2O
?
-
-
-
-
?
prothrombin + H2O
thrombin + ?
-
-
-
?
prothrombin + H2O
thrombin + ?
-
-
-
-
?
t-butyloxycarbonyl-Phe-Ser-Arg-4-methyl-coumarin 7-amide + H2O
?
-
-
-
?
t-butyloxycarbonyl-Phe-Ser-Arg-4-methyl-coumarin 7-amide + H2O
?
-
synthetic substrate, relative activity 36.3%
-
?
TGFbeta + H2O
activated TGFbeta + ?
-
activation
-
-
?
TGFbeta + H2O
activated TGFbeta + ?
-
tryptase activates TGFbeta, a key remodelling factor in asthma, in human airway smooth muscle cells via direct proteolysis in a PAR2-independent manner, TGFbeta is produced as a latent complex and the main limiting step in TGFb bioavailability is its activation, overview
-
-
?
additional information
?
-
-
biological functions and true roles of tryptase has not yet been demonstrated
-
?
additional information
?
-
equine tryptase has alanine at residue 216, rather than glycine, which confers increased arginine substrate specificity in vitro and may restrict fibrinogenolysis in vivo
-
-
?
additional information
?
-
-
equine tryptase has alanine at residue 216, rather than glycine, which confers increased arginine substrate specificity in vitro and may restrict fibrinogenolysis in vivo
-
-
?
additional information
?
-
-
pituitary enzyme has a preference for cleaving COOH-terminal to arginine or lysine residues which are preceded by a proline residue 4 or 6 residues NH2-terminal to the site of cleavage
-
-
?
additional information
?
-
-
kininogenase activity
-
-
?
additional information
?
-
-
the enzyme inactivates fibrinogen and high-molecular weight kininogen and converts C3 to C3a
-
-
?
additional information
?
-
-
the enzyme inactivates fibrinogen and high-molecular weight kininogen and converts C3 to C3a
-
-
?
additional information
?
-
-
skin and lung enzymes have both extended substrate-binding sites and proline residues at P3 substantially decrease kcat/Km, both enzymes prefer the tripeptide 4-nitroanilides with a P2 Gly residue over Phe, both favour the substrate benzyloxycarbonyl-Lys-Gly-Arg 4-nitroanilide over similar substrates containing six other representive amino acid residues at P3
-
-
?
additional information
?
-
-
4 closely related isoenzymes, tryptase alpha, I tryptase, tryptase II/beta and III tryptase, preferentially cleaves peptide substrates carboxy-terminal to arginine and lysine residues, hydrolyses bronchodilatatory neuropeptides, vasoactive intestinal peptide and peptide histidine methionine in vitro, cleaves fibrinogen and fibronectin inactivating, and activating the zymogens of stromelysin-1 and urokinase-type plasminogen activator
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?
additional information
?
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-
Ile-Phe-Lys-p-nitroanilide, N-acetyl-Ile-Glu-Ala-Arg-p-nitroanilide, N-benzoyl-Arg-p-nitroanilide, N-benzoyl-Ile-Glu-Gly-Arg-p-nitroanilide, N-benzoyl-Phe-Val-Arg-p-nitroanilide, or N-benzoyl-Pro-Phe-Arg-p-nitroanilide are no substrates
-
?
additional information
?
-
-
little or no reaction with Suc-Ala-Ala-Pro-Phe-p-nitroanilide and MeO-Suc-Arg-Pro-Tyr-p-nitroanilide
-
?
additional information
?
-
-
tryptases betaI and betaII have a strict preference for cleavage after the basic amino acids, lysine and arginine, with only a slight preference for lysine over arginine, prefernce for proline at P4, preference for arginine or lysine at P3 and P2, these enzymes are not controlled by blood plasma proteinase inhibitors and only cleave a few physiological substrates in vitro
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?
additional information
?
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-
unlike beta-tryptases, alpha-tryptases apparently are proteolytically inactive
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?
additional information
?
-
-
tryptase may have kallikrein-like activity under physiological conditions, tryptase could be of importance in the generation of kinnins subsequent to mast cell activation
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-
?
additional information
?
-
-
potential biological activities of human enzyme: 1. fibrinogenolysis, prevents clotting at local sites of mast cell activation
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-
?
additional information
?
-
-
the preference of the skin tryptase for substrates with 2 terminal basic residues indicates that this enzyme could process prohormones and proproteins which contain this structural feature at the cleavage site
-
-
?
additional information
?
-
-
2. augmentation of histamine-mediated contractility of airway smooth, increases airway hyperreactivity to histamine and allergens, 3. degradation of vasoactive intestinal peptide, decreases endogenous bronchodilatory activity in lung 4. activation of prostromelysin, facilitates activation of procollagenase and tissue remodeling, 5. degradation of fibronectin, tissue remodeling, 6. stimulation of fibroblast proliferation, enhances fibrogenesis or wound repair
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-
?
additional information
?
-
-
currently unknown whether tryptases perform redundant or unique functions in vivo
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?
additional information
?
-
-
tryptase activates PKB in inflammatory reaction in ECV304 cells, tryptase can activate phosphoinositol-3-kinase/protein kinase B pathway and enhance IL-8 expression
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?
additional information
?
-
-
beta-tryptase is involved in the pathogenesis of airway inflammation, the enzyme accounts for more than 25% or total protein in human mast cells, activated cells release the enzyme along with histamine and heparin proteoflycans, overview
-
-
?
additional information
?
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-
the enzyme is an inflammation mediator
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-
?
additional information
?
-
-
the enzyme is involved in allergic inflammation, mechanism, overview
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-
?
additional information
?
-
-
the lack of eosinophils in asthmatic airway smooth muscle bundles in contrast to the large number of mast cells is a key feature of asthma and is caused by beta-tryptase abrogating the eosinophil chemotactic activities of ASM cell-derived eosinophil chemoattractants such as eotaxin and RANTES, overview
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-
?
additional information
?
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beta-tryptase is a tetramer that has enzymatic activity, but requires heparin binding to maintain functional and structural stability, alpha-tryptase has little, if any, enzymatic activity but is a stable tetramer in the absence of heparin, both forms are in a two-state equilibrium, which is influenced by the residues in the vicinity of the active site and by inhibitor/substrate binding, substrate binding structure, overview, Asp216 and Lys192 are the main determinants of tryptase activity
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-
?
additional information
?
-
-
the enzyme is a serine protease that is a major and selective component of the secretory granules of all human mast cells, active monomers of human beta-tryptase have expanded substrate specificities, overview
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-
?
additional information
?
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-
the unique structure of the proteinase comprises four almost identical monomer subunits arranged in a square flat ring with its substrate pockets faced inside, forming a tetramer with a central pore that can be penetrated by a short peptide, the optimal length of the tryptase substrate is a pentasaccharide, substrate specificity and cleavage pattern, screening of a peptide library, overview
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-
?
additional information
?
-
-
beta-tryptase enhances release of vascular endothelial growth factor from human osteoarthritic chondrocytes
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-
?
additional information
?
-
-
the enzyme cleaves preferentially after Lys/Arg residues
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-
?
additional information
?
-
-
the enzyme is an inflammation mediator, mMCP-6 is a major storage component of connective tissue-type mast cells, and is not normally released into the environment
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-
?
additional information
?
-
-
the enzyme is involved in allergic inflammation, mechanism, overview
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-
?
additional information
?
-
-
mast cell secretion of the tryptase MCP-6 contributes to eosinophil recruitment to the site of Trichinella spiralis larval infection
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-
?
additional information
?
-
-
mast cell-derived tryptase-heparin complexes play important roles in mouse bovine serum albumin/interleukin-1beta-induced arthritis
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-
?
additional information
?
-
-
ferritin is not a substrate for tryptase
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-
?
additional information
?
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-
the enzyme cleaves preferentially after Lys/Arg residues
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-
?
additional information
?
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-
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?
additional information
?
-
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specificity overview: peptide 4-nitroanilides
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?
additional information
?
-
-
specificity overview: peptide 4-nitroanilides
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?
additional information
?
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-
specificity overview: peptide 4-nitroanilides
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?
additional information
?
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not: casein, hemoglobin, azocoll
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?
additional information
?
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-
no activation of the precursor of matrix metalloproteinase 2
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-
?
additional information
?
-
-
enzyme plays a crucial role in the process of degranulation
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-
?
additional information
?
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activity only toward substrates with Arg at the P1 position, only 0.3% and 0.1% activity with t-butyloxycarbonyl-Val-Leu-Lys-4-methylcoumarin 7-amide and Arg-4-methylcoumarin 7-amide, Suc-Ala-Pro-Ala-4-methylcoumarin 7-amide and Suc-Leu-Leu-Val-Leu-4-methylcoumarin 7-amide are no substrates
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?
additional information
?
-
-
post-translational proteolytic cleavage of the precursors of the fusion glycoproteins of enveloped RNA viruses is indispensable for their fusion activity and infectivity, enzyme triggers infection by pneumotropic Sendai and influenza A viruses by processing
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?
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(2S)-1-acetyl-N-[4-[(aminoiminomethyl)amino]-1-(2-benzothiazolylcarbonyl)butyl]-2,5-dihydro-1H-pyrrole-2-carboxamide
-
-
(2S)-1-acetyl-N-[4-[(aminoiminomethyl)amino]-1-(2-benzothiazolylcarbonyl)butyl]-2-azetidinearboxamide
-
-
(2S)-1-acetyl-N-[4-[(aminoiminomethyl)amino]-1-(2-benzothiazolylcarbonyl)butyl]-2-pyrrolidinecarboxamide
-
-
(2S)-2-acetylamino-N-[4-[(aminoiminomethyl)amino]-1-(2-benzothiazolylcarbonyl)butyl]-4-methylpentanamide
-
-
(Arg-Trp-Lys-Gly)4(Lys)2Lys-NH2
-
noncompetitive
(Lys-Lys-Phe-Gly)4(Lys)2Lys-NH2
-
noncompetitive
1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl-methyl 4-[[(phenylmethoxy)carbonyl]amino]-benzoate
-
-
1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl-methyl 5-[[(phenylmethoxy)carbonyl]amino]-pentanoate
-
-
1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl-methyl N-[(phenylmethoxy)carbonyl]-beta-alanate
-
-
1,2,5-thiadiazolidin-3-one 1,1-dioxide
-
1,2,5-zhiadiazolidin-3-one 1,1-dioxide-based heterocyclic sulfides are potent inhibitors
1,2-benzisothiazol-3-one 1,1-dioxide
-
-
1-acetyl-N-[(1S)-1-([5-[4-(2,3-dihydro-1H-inden-2-ylcarbamoyl)benzyl]-1,2,4-oxadiazol-3-yl]carbonyl)-3-pyrrolidin-3-ylpropyl]prolinamide
-
-
1-methylethyl [5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]carbamate
-
-
2-methoxyethyl [5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]carbamate
-
-
3-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]-1,1-diethylurea
-
-
3-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]-1,1-dimethylurea
-
-
4',6-Diamidino-2-phenylindole
-
-
4'-[[5-(phenylethynyl)furan-2-yl]carbonyl]spiro[1-benzofuran-3,1'-cyclohexane]-5-carboxamide
-
-
4'-[[5-(phenylethynyl)furan-2-yl]carbonyl]spiro[1-benzofuran-3,1'-cyclohexane]-5-carboximidamide
-
-
4-Amidinophenylpyruvic acid
-
-
4-amino-N-[(9S,12R,16R)-16-(4-aminobutyl)-12-[(2S)-butan-2-yl]-9-(4-hydroxybenzyl)-2,6,11,14,18-pentaoxo-1,5,10,13,17-pentaazabicyclo[17.2.1]docos-7-en-3-yl]butanamide
-
-
4-Methylumbelliferyl 4-guanidinobenzoate
-
-
4-nitrophenyl 4-guanidinobenzoate
-
-
5-amino-N-[(9S,12R,16R)-16-(4-aminobutyl)-12-[(2S)-butan-2-yl]-9-(4-hydroxybenzyl)-2,6,11,14,18-pentaoxo-1,5,10,13,17-pentaazabicyclo[17.2.1]docos-7-en-3-yl]pentanamide
-
-
6-amidino-2-naphthyl p-guanidinobenzoate dimethane sulfonate
-
nafamostat mesilate
6-amino-N-[(9S,12R,16R)-12-[(2S)-butan-2-yl]-16-(3-carbamimidamidopropyl)-9-(4-hydroxybenzyl)-2,6,11,14,18-pentaoxo-1,5,10,13,17-pentaazabicyclo[17.2.1]docos-7-en-3-yl]hexanamide
-
-
6-amino-N-[(9S,12R,16R)-16-(4-aminobutyl)-12-[(2S)-butan-2-yl]-9-(4-hydroxybenzyl)-2,6,11,14,18-pentaoxo-1,5,10,13,17-pentaazabicyclo[17.2.1]docos-7-en-3-yl]hexanamide
-
-
7-amino-N-[(9S,12R,16R)-16-(4-aminobutyl)-12-[(2S)-butan-2-yl]-9-(4-hydroxybenzyl)-2,6,11,14,18-pentaoxo-1,5,10,13,17-pentaazabicyclo[17.2.1]docos-7-en-3-yl]heptanamide
-
-
acetyl [(1S)-5-amino-1-([5-[4-(2,3-dihydro-1H-inden-2-ylcarbamoyl)benzyl]-1,2,4-oxadiazol-3-yl]carbonyl)pentyl]carbamate
-
-
acetyl-PRNK-chloromethylketone
-
-
Arg-Trp-Lys-Gly-NH2
-
noncompetitive
benzyl 4-[(3-[N2-[(benzyloxy)carbonyl]-L-lysyl]-1,2,4-oxadiazol-5-yl)methyl]piperazine-1-carboxylate
-
-
benzyl [(1S)-2-(1,3-benzothiazol-2-yl)-1-(1H-indol-2-ylmethyl)-2-oxoethyl]carbamate
-
-
benzyl [(1S)-2-(1,3-benzothiazol-2-yl)-2-oxo-1-(1H-pyrrolo[2,3-c]pyridin-2-ylmethyl)ethyl]carbamate
-
-
benzyl [(1S)-5-amino-1-(1,3-benzothiazol-2-ylcarbonyl)pentyl]carbamate
-
-
benzyl [(1S)-5-amino-1-([5-[4-(2,3-dihydro-1H-inden-2-ylcarbamoyl)benzyl]-1,2,4-oxadiazol-3-yl]carbonyl)pentyl]carbamate
-
-
benzyl [(1S)-5-amino-1-([5-[4-(benzylcarbamoyl)benzyl]-1,2,4-oxadiazol-3-yl]carbonyl)pentyl]carbamate
-
-
benzyl [(1S)-5-amino-1-([5-[4-(benzyloxy)benzyl]-1,2,4-oxadiazol-3-yl]carbonyl)pentyl]carbamate
-
-
benzyl [(1S)-5-amino-1-([5-[4-([2-[3-(trifluoromethyl)phenyl]ethyl]carbamoyl)benzyl]-1,2,4-oxadiazol-3-yl]carbonyl)pentyl]carbamate
-
-
benzyl [(1S)-5-amino-1-([5-[4-([2-[4-(trifluoromethyl)phenyl]ethyl]carbamoyl)benzyl]-1,2,4-oxadiazol-3-yl]carbonyl)pentyl]carbamate
-
-
benzyl [(1S)-5-amino-1-[(5-[4-[(2-thiophen-2-ylethyl)carbamoyl]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]carbamate
-
-
benzyl [(1S)-5-amino-1-[(5-[4-[(3,4-dimethylbenzyl)carbamoyl]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]carbamate
-
-
benzyl [(1S)-5-amino-1-[(5-[4-[(3-methylbutyl)carbamoyl]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]carbamate
-
-
benzyl [(1S)-5-amino-1-[(5-[4-[(3-phenylpropyl)carbamoyl]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]carbamate
-
-
benzyl [(1S)-5-amino-1-[(5-[4-[(4-phenylbutyl)carbamoyl]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]carbamate
-
-
benzyl [(1S)-5-amino-1-[(5-[4-[(naphthalen-1-ylmethyl)carbamoyl]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]carbamate
-
-
benzyl [(1S)-5-amino-1-[(5-[4-[(naphthalen-2-ylmethyl)carbamoyl]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]carbamate
-
-
benzyl [(1S)-5-amino-1-[(5-[[4-(3-phenylpropanoyl)piperazin-1-yl]methyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]carbamate
-
-
benzyl [(1S)-5-amino-1-[(5-[[4-(3-phenylpropyl)piperazin-1-yl]methyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]carbamate
-
-
benzyl [(1S)-5-amino-1-[(5-[[4-(4-phenylbutanoyl)piperazin-1-yl]methyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]carbamate
-
-
benzyl [(1S)-5-amino-1-[(5-[[4-(4-phenylbutyl)piperazin-1-yl]methyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]carbamate
-
-
benzyl [(1S)-5-amino-1-[[5-(4-methoxybenzyl)-1,2,4-oxadiazol-3-yl]carbonyl]pentyl]carbamate
-
-
benzyl [(1S)-5-amino-1-[[5-(4-[[(2E)-3-phenylprop-2-en-1-yl]carbamoyl]benzyl)-1,2,4-oxadiazol-3-yl]carbonyl]pentyl]carbamate
-
-
benzyl [(1S)-5-amino-1-[[5-(4-[[2-(3,4-dichlorophenyl)ethyl]carbamoyl]benzyl)-1,2,4-oxadiazol-3-yl]carbonyl]pentyl]carbamate10n
-
-
benzyl [(1S)-5-amino-1-[[5-(4-[[2-(3,5-difluorophenyl)ethyl]carbamoyl]benzyl)-1,2,4-oxadiazol-3-yl]carbonyl]pentyl]carbamate
-
-
benzyl [(1S)-5-amino-1-[[5-(4-[[2-(3-chlorophenyl)ethyl]carbamoyl]benzyl)-1,2,4-oxadiazol-3-yl]carbonyl]pentyl]carbamate
-
-
benzyl [(1S)-5-amino-1-[[5-(4-[[2-(4-fluorophenoxy)ethyl]carbamoyl]benzyl)-1,2,4-oxadiazol-3-yl]carbonyl]pentyl]carbamate
-
-
benzyl [(1S)-5-amino-1-[[5-(4-[[4-(2-fluorobenzyl)piperazin-1-yl]carbonyl]benzyl)-1,2,4-oxadiazol-3-yl]carbonyl]pentyl]carbamate
-
-
benzyl [(1S,3E)-5-amino-1-(1,3-benzothiazol-2-ylcarbonyl)pent-3-en-1-yl]carbamate
-
-
benzyl((1S)-5-amino-1-[(5-(4-[(2,4-dichlorobenzyl)oxy]benzyl)-1,2,4-oxadiazol-3-yl)carbonyl]pentyl)carbamate
-
-
benzyl((1S)-5-amino-1-[(5-(4-[(3,4-dichlorobenzyl)oxy]benzyl)-1,2,4-oxadiazol-3-yl)carbonyl]pentyl)carbamate
-
-
benzyl((1S)-5-amino-1-[(5-(4-[(3,4-dimethoxybenzyl)oxy]benzyl)-1,2,4-oxadiazol-3-yl)carbonyl]pentyl)carbamate
-
-
benzyl((1S)-5-amino-1-[(5-(4-[(3-chlorobenzyl)oxy]benzyl)-1,2,4-oxadiazol-3-yl)carbonyl]pentyl)carbamate
-
-
benzyl((1S)-5-amino-1-[(5-(4-[(3-methoxybenzyl)oxy]benzyl)-1,2,4-oxadiazol-3-yl)carbonyl]pentyl)carbamate
-
-
benzyl((1S)-5-amino-1-[(5-(4-[(4-chlorobenzyl)oxy]benzyl)-1,2,4-oxadiazol-3-yl)carbonyl]pentyl)carbamate
-
-
benzyl((1S)-5-amino-1-[(5-(4-[(4-fluorobenzyl)oxy]benzyl)-1,2,4-oxadiazol-3-yl)carbonyl]pentyl)carbamate
-
-
benzyl((1S)-5-amino-1-[(5-(4-[(4-methoxybenzyl)oxy]benzyl)-1,2,4-oxadiazol-3-yl)carbonyl]pentyl)carbamate
-
-
benzyl((1S)-5-amino-1-[(5-benzyl-1,2,4-oxadiazol-3-yl)carbonyl]pentyl)carbamate
-
-
benzyl((benzyl ((1S)-5-amino-1-[(5-(4-[(3,4-dimethoxybenzyl)oxy]benzyl)-1,2,4-oxadiazol-3-yl)carbonyl]pentyl)carbamate1S)-5-amino-1-[(5-(4-[(3-methoxybenzyl)oxy]benzyl)-1,2,4-oxadiazol-3-yl)carbonyl]pentyl)carbamate
-
-
benzyl[(1S)-5-amino-1-((5-[3-(2-phenylethoxy)benzyl]-1,2,4-oxadiazol-3-yl)carbonyl)pentyl]carbamate
-
-
benzyl[(1S)-5-amino-1-((5-[3-(3-phenylpropoxy)benzyl]-1,2,4-oxadiazol-3-yl)carbonyl)pentyl]carbamate
-
-
benzyl[(1S)-5-amino-1-((5-[4-(2-phenylethoxy)benzyl]-1,2,4-oxadiazol-3-yl)carbonyl)pentyl]carbamate
-
-
benzyl[(1S)-5-amino-1-((5-[4-(3-phenylpropoxy)benzyl]-1,2,4-oxadiazol-3-yl)carbonyl)pentyl]carbamate
-
-
benzyl[(1S)-5-amino-1-((5-[4-(benzyloxy)benzyl]-1,2,4-oxadiazol-3-yl)carbonyl)pentyl]carbamate
-
-
benzyl[(1S)-5-amino-1-((5-[4-(cyclohexylmethoxy)benzyl]-1,2,4-oxadiazol-3-yl)carbonyl)pentyl]carbamate
-
-
benzyl[(1S)-5-amino-1-((5-[4-(naphthalen-1-ylmethoxy)benzyl]-1,2,4-oxadiazol-3-yl)carbonyl)pentyl]carbamate
-
-
benzyl[(1S)-5-amino-1-((5-[4-(naphthalen-2-ylmethoxy)benzyl]-1,2,4-oxadiazol-3-yl)carbonyl)pentyl]carbamate
-
-
Bovine pancreatic trypsin inhibitor
-
Calcium
-
5 mM is needed to cause an irreversible 50% loss of activity after 60 min at room temperature
c[-Pro-beta3hArg(3-H2N-CH2)-D-allo-Ile-vTyr-NH-CH2-CH(NHAc)-CO-]
-
-
c[-Pro-beta3hArg(3-H2N-CH2)-D-allo-Ile-vTyr-NH-CH2-CH(NHCO-(CH2)5-NH2)-CO-]
-
-
c[-Pro-beta3hPhe(3-H2N-CH2)-D-allo-Ile-vTyr-NH-CH2-CH(NHCO-(CH2)5-NH2)-CO-]
-
-
c[-Pro-beta3Lys(3-H2N-CH2)-D-allo-Ile-vTyr-NH-CH2-CH(NHAc)-CO-]
-
-
D-Tyr-Glu-Phe-Lys-Arg-CH2Cl
-
-
Dansyl-L-glutamyl-glycyl-L-arginine chloromethyl ketone
-
-
diisopropyl fluorophosphate
diisopropylfluorophosphate
ethyl [(1S)-5-amino-1-([5-[4-(2,3-dihydro-1H-inden-2-ylcarbamoyl)benzyl]-1,2,4-oxadiazol-3-yl]carbonyl)pentyl]carbamate
-
-
ethyl [(1S)-5-amino-1-[[5-(4-[[2-(3-chlorophenyl)ethyl]carbamoyl]benzyl)-1,2,4-oxadiazol-3-yl]carbonyl]pentyl]carbamate
-
-
ethyl [5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]carbamate
-
-
ethyl[(1S)-5-amino-1-((5-[4-(2-phenylethoxy)benzyl]-1,2,4-oxadiazol-3-yl)carbonyl)pentyl]carbamate
-
-
ferritin
-
ferritin can retard the cleavage of both native oxidized high-molecular-weight kininogen by tryptase, initial rates of cleavage are reduced 45-75% in the presence of ferritin
-
FUT175
-
a selective tryptase inhibitor
Glu-Gly-Arg chloromethyl ketone
-
leech-derived tryptase inhibitor
-
nanomolar inhibitor
-
Lys-Lys-Phe-Gly-NH2
-
noncompetitive
M58539
-
i.e. N-[3-[4-(aminomethyl)phenyl]propyl]-N'-[(1-chloronaphthalen-2-yl)sulfanyl]ethane-1,2-diamine, a highly selective inhibitor
MCoTI-II derived miniprotein
-
nanomolar inhibitor
-
MCoTI-II-DELTA[GSDGV]
-
-
-
MCoTI-II-DELTA[SDGGV]
-
-
-
MCoTI-II-DELTA[SDGG]
-
-
-
MCoTI-II-DELTA[SDGG][K10R]
-
-
-
MCoTI-II[K10V]-[I11P]
-
-
-
MCoTI-II[PKI]-[AVP]
-
-
-
methyl 4'-[3-([(6-chloronaphthalen-2-yl)sulfonyl][2-[(2-hydroxyethyl)(methyl)amino]-2-oxoethyl]amino)-2-oxopiperidin-1-yl]-3'-fluorobiphenyl-2-sulfinate
-
-
methyl [(1S)-1-([5-[4-(2,3-dihydro-1H-inden-2-ylcarbamoyl)benzyl]-1,2,4-oxadiazol-3-yl]carbonyl)-3-pyrrolidin-3-ylpropyl]carbamate
-
-
methyl [5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]carbamate
-
-
MOL 6131
-
developed against mast cell beta-tryptase and studied in ovalbumin-induced allergic airway inflammation
mucus protease inhibitor
-
-
-
N-tosyl-L-Lys chloromethyl ketone
N-tosyl-L-Phe chloromethyl ketone
N-[(1S)-1-([5-[4-(2,3-dihydro-1H-inden-2-ylcarbamoyl)benzyl]-1,2,4-oxadiazol-3-yl]carbonyl)-3-piperidin-4-ylpropyl]-3,4-difluorobenzamide
-
-
N-[(1S)-1-([5-[4-(2,3-dihydro-1H-inden-2-ylcarbamoyl)benzyl]-1,2,4-oxadiazol-3-yl]carbonyl)-3-pyrrolidin-3-ylpropyl]-3,4-difluorobenzamide
-
-
N-[(1S)-3-azetidin-3-yl-1-([5-[4-(2,3-dihydro-1H-inden-2-ylcarbamoyl)benzyl]-1,2,4-oxadiazol-3-yl]carbonyl)propyl]-3,4-difluorobenzamide
-
-
N-[(1S)-5-amino-1-([5-[4-(2,3-dihydro-1H-inden-2-ylcarbamoyl)benzyl]-1,2,4-oxadiazol-3-yl]carbonyl)pentyl]-3,4-difluorobenzamide
-
-
N-[(1S)-5-amino-1-[[5-(4-[[2-(3-chlorophenyl)ethyl]carbamoyl]benzyl)-1,2,4-oxadiazol-3-yl]carbonyl]pentyl]-1,3-benzodioxole-5-carboxamide
-
-
N-[(1S)-5-amino-1-[[5-(4-[[2-(3-chlorophenyl)ethyl]carbamoyl]benzyl)-1,2,4-oxadiazol-3-yl]carbonyl]pentyl]-3,4-difluorobenzamide
-
-
N-[(1S)-5-amino-1-[[5-(4-[[2-(3-chlorophenyl)ethyl]carbamoyl]benzyl)-1,2,4-oxadiazol-3-yl]carbonyl]pentyl]-3,5-difluorobenzamide
-
-
N-[(1S)-5-amino-1-[[5-(4-[[2-(3-chlorophenyl)ethyl]carbamoyl]benzyl)-1,2,4-oxadiazol-3-yl]carbonyl]pentyl]-3-fluorobenzamide
-
-
N-[(1S)-5-amino-1-[[5-(4-[[2-(3-chlorophenyl)ethyl]carbamoyl]benzyl)-1,2,4-oxadiazol-3-yl]carbonyl]pentyl]-4-chlorobenzamide
-
-
N-[(1S)-5-amino-1-[[5-(4-[[2-(3-chlorophenyl)ethyl]carbamoyl]benzyl)-1,2,4-oxadiazol-3-yl]carbonyl]pentyl]-4-fluorobenzamide
-
-
N-[(9S,12R,16R)-12-[(2S)-butan-2-yl]-16-(3-carbamimidamidopropyl)-9-(4-hydroxybenzyl)-2,6,11,14,18-pentaoxo-1,5,10,13,17-pentaazabicyclo[17.2.1]docos-7-en-3-yl]acetamide
-
-
N-[(9S,12R,16R)-16-(4-aminobutyl)-12-[(2S)-butan-2-yl]-9-(4-hydroxybenzyl)-2,6,11,14,18-pentaoxo-1,5,10,13,17-pentaazabicyclo[17.2.1]docos-7-en-3-yl]acetamide
-
-
N-[2-(3-chlorophenyl)ethyl]-4-([3-[N2-(2,2-dimethylpropanoyl)-L-lysyl]-1,2,4-oxadiazol-5-yl]methyl)benzamide
-
-
N-[3-[4-(aminomethyl)phenyl]propyl]-N'-(1,2,3,4-tetrahydroisoquinolin-7-ylsulfanyl)ethane-1,2-diamine
-
-
N-[3-[4-(aminomethyl)phenyl]propyl]-N'-(1-benzothiophen-2-ylsulfanyl)ethane-1,2-diamine
-
-
N-[3-[4-(aminomethyl)phenyl]propyl]-N'-(1-benzothiophen-5-ylsulfanyl)ethane-1,2-diamine
-
-
N-[3-[4-(aminomethyl)phenyl]propyl]-N'-(2,3-dihydro-1H-inden-5-ylsulfanyl)ethane-1,2-diamine
-
-
N-[3-[4-(aminomethyl)phenyl]propyl]-N'-(naphthalen-2-ylsulfanyl)ethane-1,2-diamine
-
-
N-[3-[4-(aminomethyl)phenyl]propyl]-N'-(phenylsulfanyl)ethane-1,2-diamine
-
-
N-[3-[4-(aminomethyl)phenyl]propyl]-N'-[(2-methyl-1,3-benzothiazol-6-yl)sulfanyl]ethane-1,2-diamine
-
-
N-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]-2,2,2-trifluoroacetamide
-
-
N-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]-2,2-dimethylpropanamide
-
-
N-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]-2,4-difluorobenzamide
-
-
N-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]-2,5-dimethylfuran-3-carboxamide
-
-
N-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]-2-fluorobenzamide
-
-
N-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]-2-methoxyacetamide
-
-
N-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]-2-methylpropanamide
-
-
N-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]-3,4-difluorobenzamide
-
-
N-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]-3-fluorobenzamide
-
-
N-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]-4-chlorobenzamide
-
-
N-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]-4-fluorobenzamide
-
-
N-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]cyclopentanecarboxamide
-
-
N-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]cyclopropanecarboxamide
-
-
N-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]furan-2-carboxamide
-
-
N-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]hexanamide
-
-
N-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]morpholine-4-carboxamide
-
-
N-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]piperidine-1-carboxamide
-
-
N-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]pyrrolidine-1-carboxamide
-
-
N-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]tetrahydrofuran-3-carboxamide
-
-
Nafamostat
-
complete inhibition at 0.1 mM
neutrophil myeloperoxidase
-
important component of the neutrophil response to microbial infection, high concentrations of heparin can prevent the inhibition of tryptase by MPO
-
p-Aminophenylmethanesulfonyl fluoride
-
lung enzyme is inhibited over 3times faster than the skin enzyme
p-chloromercuribenzoate
-
-
Pentamidine
-
nonselective inhibitor
Peptide chloromethyl ketone inhibitors
-
-
-
prop-2-en-1-yl [(1S)-1-([5-[4-(2,3-dihydro-1H-inden-2-ylcarbamoyl)benzyl]-1,2,4-oxadiazol-3-yl]carbonyl)-3-pyrrolidin-3-ylpropyl]carbamate
-
-
rLDTI
-
recombinant leech-derived tryptase inhibitor
-
Soybean trypsin inhibitor
-
Sulfonyl fluoride inhibitors
-
-
trans-4-(Guanidinomethyl)cyclohexanecarboxylic acid esters
-
most effective: trans-4-(guanidinomethyl)cyclohexanecarboxylic acid butylphenyl ester
Tryptase inhibitor
-
derived from the medical leech Hirudo medicinalis
-
[1'-(acetyloxy)-5'-(aminomethyl)-1',2'-dihydrospiro[cyclohexane-1,3'-indol]-4-yl][5-(phenylethynyl)furan-2-yl]methanone
-
-
[5'-(aminomethyl)-1',2'-dihydrospiro[cyclohexane-1,3'-indol]-4-yl][5-(phenylethynyl)furan-2-yl]methanone
-
-
[5'-(aminomethyl)-1'-[(methylsulfinyl)oxy]-1',2'-dihydrospiro[cyclohexane-1,3'-indol]-4-yl][5-(phenylethynyl)furan-2-yl]methanone
-
-
[5'-(aminomethyl)-1'-[(phenylsulfinyl)oxy]-1',2'-dihydrospiro[cyclohexane-1,3'-indol]-4-yl][5-(phenylethynyl)furan-2-yl]methanone
-
-
[5-(aminomethyl)spiro[1-benzofuran-3,1'-cyclohexan]-4'-yl](5-benzylfuran-2-yl)methanone
-
-
[5-(aminomethyl)spiro[1-benzofuran-3,1'-cyclohexan]-4'-yl][5-(2-phenylethyl)furan-2-yl]methanone
-
-
[5-(aminomethyl)spiro[1-benzofuran-3,1'-cyclohexan]-4'-yl][5-(phenylethynyl)furan-2-yl]methanone
-
-
[5-(aminomethyl)spiro[1-benzofuran-3,1'-cyclohexan]-4'-yl][5-(phenylsulfanyl)furan-2-yl]methanone
-
-
[5-(aminomethyl)spiro[1-benzofuran-3,1'-cyclohexan]-4'-yl][5-[(2-chlorophenyl)ethynyl]furan-2-yl]methanone
-
-
[5-(aminomethyl)spiro[1-benzofuran-3,1'-cyclohexan]-4'-yl][5-[(2-fluorophenyl)ethynyl]furan-2-yl]methanone
-
-
[5-(aminomethyl)spiro[1-benzofuran-3,1'-cyclohexan]-4'-yl][5-[(2-methoxyphenyl)ethynyl]furan-2-yl]methanone
-
-
[5-(aminomethyl)spiro[1-benzofuran-3,1'-cyclohexan]-4'-yl][5-[(2-methylphenyl)ethynyl]furan-2-yl]methanone
-
-
[5-(aminomethyl)spiro[1-benzofuran-3,1'-cyclohexan]-4'-yl][5-[(4-hydroxyphenyl)ethynyl]furan-2-yl]methanone
-
-
[5-(aminomethyl)spiro[1-benzofuran-3,1'-cyclohexan]-4'-yl][5-[(4-methylphenyl)ethynyl]furan-2-yl]methanone
-
-
[5-(aminomethyl)spiro[1-benzofuran-3,1'-cyclohexan]-4'-yl][5-[(4-tert-butylphenyl)ethynyl]furan-2-yl]methanone
-
-
[5-[(1E)-1-aminoprop-1-en-1-yl]spiro[1-benzofuran-3,1'-cyclohexan]-4'-yl][5-(phenylethynyl)furan-2-yl]methanone
-
-
[6'-(aminomethyl)-2',3'-dihydrospiro[cyclohexane-1,1'-inden]-4-yl][5-(phenylethynyl)furan-2-yl]methanone
-
-
alpha1-antitrypsin
-
human and dog enzyme insensitive
-
alpha1-antitrypsin
-
human and dog enzyme insensitive
-
alpha1-antitrypsin
-
rat peritoneal mast cell enzyme, no inhibition of skin enzyme
-
alpha1-antitrypsin
-
not
-
antipain
-
-
APC-366
-
low molecular weight active site-directed competitive tryptase inhibitor
APC366
-
N-(1-hydroxy-2-naphthoyl)-L-arginyl-L-prolinamide, selective inhibitor of mast cell tryptase
Aprotinin
-
-
Aprotinin
-
weak inhibitor
benzamidine
-
-
benzamidine
-
and derivatives
Bovine pancreatic trypsin inhibitor
-
may play a physiological role in regulation of tryptase proteolytic activity
-
Bovine pancreatic trypsin inhibitor
-
pH-dependent
-
Bovine pancreatic trypsin inhibitor
-
the functional unit of bovine tryptase is formed of at least 4 binding sites for this inhibitor
-
Bovine pancreatic trypsin inhibitor
-
-
-
BPTI
-
irreversible complex formation between protease and serpin
-
CRA-2059
-
synthetic inhibitor
diisopropyl fluorophosphate
-
-
diisopropyl fluorophosphate
-
-
diisopropyl fluorophosphate
-
-
diisopropyl fluorophosphate
-
-
diisopropylfluorophosphate
-
-
diisopropylfluorophosphate
-
-
HgCl2
-
-
LDTI
-
non-competitive inhibitor, derived from Hirudo medicinalis
-
LDTI
-
only naturally occuring inhibitor, leech-derived tryptase inhibitor
-
leupeptin
-
-
leupeptin
-
binding structure with alpha- and beta-tryptase, overview
N-tosyl-L-Lys chloromethyl ketone
-
-
N-tosyl-L-Lys chloromethyl ketone
-
-
N-tosyl-L-Lys chloromethyl ketone
-
-
N-tosyl-L-Lys chloromethyl ketone
-
-
N-tosyl-L-Phe chloromethyl ketone
-
weak
N-tosyl-L-Phe chloromethyl ketone
-
-
NaCl
-
-
PMSF
-
-
polybrene
-
heparin antagonist, potent inhibitor, noncompetitive inhibition
polybrene
-
heparin antagonist, potent inhibitor, noncompetitive inhibition, recombinant tryptase
protamine
-
heparin antagonist, potent inhibitor, competitive inhibition
protamine
-
heparin antagonist, potent inhibitor, competitive inhibition, recombinant tryptase
Soybean trypsin inhibitor
-
not
-
Soybean trypsin inhibitor
-
-
-
Soybean trypsin inhibitor
-
inhibition of rat peritoneal mast cell enzyme, no inhibition of skin enzyme
-
Soybean trypsin inhibitor
-
not
-
Trypstatin
-
purification
-
Trypstatin
-
inhibition above pH 7.5
-
additional information
-
not: alpha1-proteinase inhibitor; plasma
-
additional information
-
alpha2-macroglobulin; not: alpha1-proteinase inhibitor
-
additional information
-
not affected by the protein inhibitors of serine proteinases normally present in human extracellular fluids
-
additional information
-
antileukoprotease; antithrombin III; hirudin; low-molecular weight elastase inhibitor from human lung; no specific physiologic inhibitor has yet been found for the protease
-
additional information
-
lima bean trypsin inhibitor; ovomucoid inhibitor; plasma (human)
-
additional information
-
unique tryptase inasmuch as it has no endogenous inhibitors
-
additional information
-
no inhibition of native or recombinant enzyme by soybean trypsin inhibitor SBTI
-
additional information
-
library screening and inhibitor design and synthesis, inhibition mechanism, overview
-
additional information
-
design of potent and selective enzyme inhibitors based on alpha-keto-[1,2,4]-oxadiazoles, overview
-
additional information
-
synthesis and inhibitory potency of spirocyclic piperidine amide derivatives as enzyme inhibitors, overview
-
additional information
-
CXCL4 does not act as a direct beta-tryptase inhibitor, but destabilizes active tetrameric enzyme by antagonizing the heparin component required for the integrity of the tetramer
-
additional information
aprotinin only inhibits monomeric beta-tryptase mutant
-
additional information
-
aprotinin only inhibits monomeric beta-tryptase mutant
-
additional information
-
tryptase-small-interfering RNA vector inhibits tryptase expression in P815 cells, reduced tryptase expression significantly inhibits the synthesis and release of interleukin-6 and tissue necrosis factor-alpha in vascular endothelial cells
-
additional information
-
lima bean trypsin inhibitor; ovomucoid
-
additional information
-
chymostatin, E64 and pestatin have no effect
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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0.05
Ac-Arg-Asn-Lys-5-amino-2-nitrobenzoylamide
-
-
0.062
Ac-Ile-Arg-Asn-Lys-5-amino-2-nitrobenzoylamide
-
-
0.1105 - 0.1333
Ac-PANK-AAC
0.0089 - 0.0145
Ac-PRNK-AAC
0.0165 - 0.0186
Ac-PRNR-AAC
0.071
Ac-Pro-Ile-Arg-Asn-Lys-5-amino-2-nitrobenzoylamide
-
-
0.0147 - 0.0234
Ac-PRTK-AAC
0.04
Ala-Ala-Pro-Ile-Arg-Asn-Lys-5-amino-2-nitrobenzoylamide
-
-
0.053
Ala-Pro-Ile-Arg-Asn-Lys-5-amino-2-nitrobenzoylamide
-
-
0.1
Arg-Asn-Lys-5-amino-2-nitrobenzoylamide
-
-
0.0002
Benzyloxycarbonyl-Ala-Arg-Arg 4-methylcoumarin 7-amide
-
-
0.0231
benzyloxycarbonyl-Arg 4-methylcoumarin 7-amide
-
-
0.0409
Benzyloxycarbonyl-L-Ala-L-Arg-L-Arg 4-methylcoumarin 7-amide
-
-
0.323
benzyloxycarbonyl-L-Ala-L-Leu-L-Lys-7-amido-4-methylcoumarin
-
-
-
0.0138
Benzyloxycarbonyl-L-Ala-L-Lys-L-Arg 4-methylcoumarin 7-amide
-
-
0.0148
Benzyloxycarbonyl-L-Ala-L-Lys-L-Lys 4-methylcoumarin 7-amide
-
-
0.0023
bovine prothrombin
-
-
-
0.3 - 5
Bz-Arg-p-nitroanilide
0.062 - 0.081
D-Ile-Pro-Arg-4-nitroanilide
0.4 - 8.2
D-Ile-Pro-Arg-p-nitroanilide
0.7 - 0.79
D-Phe-Pip-Arg-p-nitroanilide
1.64 - 13.5
D-Pro-Phe-Arg-p-nitroanilide
1.12 - 3.49
D-Val-Leu-Arg-p-nitroanilide
5.03 - 10.5
Glu-Gly-Arg-p-nitroanilide
0.37 - 0.64
Glu-Pro-Arg-p-nitroanilide
0.111
Ile-Arg-Asn-Lys-5-amino-2-nitrobenzoylamide
-
-
0.58 - 1.16
MeOCO-Nle-Gly-Arg-p-nitroanilide
0.922
N-(p-tosyl)-Gly-Pro-Arg-4-nitroanilide
pH 8.0, 22°C
2.849
N-(p-tosyl)-Gly-Pro-Lys-p-nitroanilide
pH 8.0, 22°C
0.049 - 0.12
N-p-tosyl-Gly-Pro-Arg-p-nitroanilide
0.19 - 4.2
N-p-tosyl-Gly-Pro-Lys-p-nitroanilide
0.044
Pro-Ile-Arg-Asn-Lys-5-amino-2-nitrobenzoylamide
-
-
0.043
t-butyloxycarbonyl-Phe-Ser-Arg-4-methyl-coumarin 7-amide
-
pH 8.0, 30°C
0.0046
Tert-Butyloxycarbonyl-Gly-Lys-Arg 4-methylcoumarin 7-amide
-
-
0.029
tert-butyloxycarbonyl-Phe-Ser-Arg 4-methylcoumarin 7-amide
-
-
0.031
tert-butyloxycarbonyl-Val-Pro-Arg 4-methylcoumarin 7-amide
-
-
0.35 - 0.49
tosyl-Gly-Pro-Lys-p-nitroanilide
0.04 - 0.36
Z-D-Arg-Gly-Arg-p-nitroanilide
additional information
additional information
-
0.1105
Ac-PANK-AAC
-
pH 7.5, 30°C, betaII tryptase
0.1333
Ac-PANK-AAC
-
pH 7.5, 30°C, betaI tryptase
0.0089
Ac-PRNK-AAC
-
pH 7.5, 30°C, betaII tryptase
0.0145
Ac-PRNK-AAC
-
pH 7.5, 30°C, betaI tryptase
0.0165
Ac-PRNR-AAC
-
pH 7.5, 30°C, betaII tryptase
0.0186
Ac-PRNR-AAC
-
pH 7.5, 30°C, betaI tryptase
0.0147
Ac-PRTK-AAC
-
pH 7.5, 30°C, betaII tryptase
0.0234
Ac-PRTK-AAC
-
pH 7.5, 30°C, betaI tryptase
0.3
Bz-Arg-p-nitroanilide
-
pH 7.6, 20°C, isoform L1
1.19
Bz-Arg-p-nitroanilide
-
pH 7.6, 20°C, isoform L2
2.36
Bz-Arg-p-nitroanilide
-
pH 7.6, 20°C, isoform S2
4.8 - 5
Bz-Arg-p-nitroanilide
-
pH 7.6, 20°C, isoform S1
0.062
D-Ile-Pro-Arg-4-nitroanilide
-
pH 8.0, 25°C, active enzyme tetramer, in presence of heparin and Na+
0.081
D-Ile-Pro-Arg-4-nitroanilide
-
pH 6.8, 25°C, active enzyme tetramer, in presence of heparin and Na+
0.4
D-Ile-Pro-Arg-p-nitroanilide
-
pH 6.0, 25°C, 60 ng polybrene
0.43
D-Ile-Pro-Arg-p-nitroanilide
-
pH 6.0, 25°C, 80 ng polybrene
0.44
D-Ile-Pro-Arg-p-nitroanilide
-
pH 6.0, 25°C, 100 ng polybrene
0.46
D-Ile-Pro-Arg-p-nitroanilide
-
pH 6.0, 25°C
1.7
D-Ile-Pro-Arg-p-nitroanilide
-
pH 6.0, 25°C, 100 ng protamine
6.7
D-Ile-Pro-Arg-p-nitroanilide
-
pH 6.0, 25°C, 800 ng protamine
7.4
D-Ile-Pro-Arg-p-nitroanilide
-
pH 6.0, 25°C, 400 ng protamine
8.2
D-Ile-Pro-Arg-p-nitroanilide
-
pH 6.0, 25°C, 200 ng protamine
0.7
D-Phe-Pip-Arg-p-nitroanilide
-
pH 7.6, 20°C, isoform S1
0.78
D-Phe-Pip-Arg-p-nitroanilide
-
pH 7.6, 20°C, isoform L1 and S2
0.79
D-Phe-Pip-Arg-p-nitroanilide
-
pH 7.6, 20°C, isoform L2
1.64
D-Pro-Phe-Arg-p-nitroanilide
-
pH 7.6, 20°C, isoform L2
1.75
D-Pro-Phe-Arg-p-nitroanilide
-
pH 7.6, 20°C, isoform S2
2.59
D-Pro-Phe-Arg-p-nitroanilide
-
pH 7.6, 20°C, isoform S1
13.5
D-Pro-Phe-Arg-p-nitroanilide
-
pH 7.6, 20°C, isoform L1
1.12
D-Val-Leu-Arg-p-nitroanilide
-
pH 7.6, 20°C, isoform L2
1.41
D-Val-Leu-Arg-p-nitroanilide
-
pH 7.6, 20°C, isoform S2
3.11
D-Val-Leu-Arg-p-nitroanilide
-
pH 7.6, 20°C, isoform S1
3.49
D-Val-Leu-Arg-p-nitroanilide
-
pH 7.6, 20°C, isoform L1
5.03
Glu-Gly-Arg-p-nitroanilide
-
pH 7.6, 20°C, isoform L1
10.5
Glu-Gly-Arg-p-nitroanilide
-
pH 7.6, 20°C, isoform S1
0.37
Glu-Pro-Arg-p-nitroanilide
-
pH 7.6, 20°C, isoform L1
0.42
Glu-Pro-Arg-p-nitroanilide
-
pH 7.6, 20°C, isoforms S1 and S2
0.64
Glu-Pro-Arg-p-nitroanilide
-
pH 7.6, 20°C, isoform L2
0.58
MeOCO-Nle-Gly-Arg-p-nitroanilide
-
pH 7.6, 20°C, isoform L1
0.83
MeOCO-Nle-Gly-Arg-p-nitroanilide
-
pH 7.6, 20°C, isoform S1
1.04
MeOCO-Nle-Gly-Arg-p-nitroanilide
-
pH 7.6, 20°C, isoform L2
1.16
MeOCO-Nle-Gly-Arg-p-nitroanilide
-
pH 7.6, 20°C, isoform S2
0.049
N-p-tosyl-Gly-Pro-Arg-p-nitroanilide
-
pH 7.4, 37°C, tryptase beta/II
0.12
N-p-tosyl-Gly-Pro-Arg-p-nitroanilide
-
pH 7.4, 37°C, D215G mutant
0.19
N-p-tosyl-Gly-Pro-Lys-p-nitroanilide
-
pH 6.0, 25°C, 1200 ng polybrene
0.2
N-p-tosyl-Gly-Pro-Lys-p-nitroanilide
-
pH 6.0, 25°C, 600 ng polybrene
0.21
N-p-tosyl-Gly-Pro-Lys-p-nitroanilide
-
pH 6.0, 25°C, 800 ng or 1000 ng polybrene
0.27
N-p-tosyl-Gly-Pro-Lys-p-nitroanilide
-
pH 6.0, 25°C
0.41
N-p-tosyl-Gly-Pro-Lys-p-nitroanilide
-
pH 6.0, 25°C, 0.001 mg protamine
0.53
N-p-tosyl-Gly-Pro-Lys-p-nitroanilide
-
pH 6.0, 25°C, 0.0015 mg protamine
0.64
N-p-tosyl-Gly-Pro-Lys-p-nitroanilide
-
pH 6.0, 25°C, 0.002 mg protamine
3.5
N-p-tosyl-Gly-Pro-Lys-p-nitroanilide
-
pH 8.2, 22°C, recombinant tryptase
4.2
N-p-tosyl-Gly-Pro-Lys-p-nitroanilide
-
pH 8.2, 22°C, HMC-1 tryptase
0.32
S-2288
mutant enzyme Y75C, at pH 6.8 and 25°C
0.47
S-2288
wild type enzyme, at pH 6.8 and 25°C
0.82
S-2288
mutant enzyme I99C, at pH 6.8 and 25°C
1
S-2288
mutant enzyme I99C/Y75A/Y37bA, at pH 6.8 and 25°C
1.6
S-2288
mutant enzyme I99C*/Y75A/Y37bA, at pH 6.8 and 25°C
0.35
tosyl-Gly-Pro-Lys-p-nitroanilide
-
pH 7.6, 20°C, isoform L1
0.44
tosyl-Gly-Pro-Lys-p-nitroanilide
-
pH 7.6, 20°C, isoforms S1 and S2
0.49
tosyl-Gly-Pro-Lys-p-nitroanilide
-
pH 7.6, 20°C, isoform L2
0.04
Z-D-Arg-Gly-Arg-p-nitroanilide
-
pH 7.6, 20°C, isoform L1
0.15
Z-D-Arg-Gly-Arg-p-nitroanilide
-
pH 7.6, 20°C, isoform S2
0.23
Z-D-Arg-Gly-Arg-p-nitroanilide
-
pH 7.6, 20°C, isoform L2
0.36
Z-D-Arg-Gly-Arg-p-nitroanilide
-
pH 7.6, 20°C, isoform S1
additional information
additional information
-
-
-
additional information
additional information
kinetics
-
additional information
additional information
-
kinetics
-
additional information
additional information
-
effect of NaCl on Km
-
additional information
additional information
-
overview: Km values of peptide 4-nitroanilide substrates
-
additional information
additional information
-
overview: Km values of peptide 4-nitroanilide substrates
-
additional information
additional information
-
overview: kinetic constant for the hydrolysis of synthetic thioester substrates and 4-nitroanilide substrates by the lung and by the skin enzyme
-
additional information
additional information
-
kinetics and binding constants
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
141
Ac-Arg-Asn-Lys-5-amino-2-nitrobenzoylamide
-
-
367
Ac-Ile-Arg-Asn-Lys-5-amino-2-nitrobenzoylamide
-
-
378
Ac-Pro-Ile-Arg-Asn-Lys-5-amino-2-nitrobenzoylamide
-
-
187
Ala-Ala-Pro-Ile-Arg-Asn-Lys-5-amino-2-nitrobenzoylamide
-
-
233
Ala-Pro-Ile-Arg-Asn-Lys-5-amino-2-nitrobenzoylamide
-
-
159
Arg-Asn-Lys-5-amino-2-nitrobenzoylamide
-
-
0.8
Benzyloxycarbonyl-Ala-Arg-Arg 4-methylcoumarin 7-amide
-
-
0.05
benzyloxycarbonyl-Arg 4-methylcoumarin 7-amide
-
-
5.35 - 5.52
benzyloxycarbonyl-Arg 4-nitroanilide
104 - 107
Benzyloxycarbonyl-Gly-Arg 4-trifluoromethylcoumarin 7-amide
551 - 553
Benzyloxycarbonyl-Gly-Pro-Arg 4-nitroanilide
2040
Benzyloxycarbonyl-L-Ala-L-Arg-L-Arg 4-methylcoumarin 7-amide
-
-
1870
benzyloxycarbonyl-L-Ala-L-Leu-L-Lys-7-amido-4-methylcoumarin
-
-
-
3290
Benzyloxycarbonyl-L-Ala-L-Lys-L-Arg 4-methylcoumarin 7-amide
-
-
1520
Benzyloxycarbonyl-L-Ala-L-Lys-L-Lys 4-methylcoumarin 7-amide
-
-
45.7
Benzyloxycarbonyl-Lys-Arg 4-trifluoromethylcoumarin 7-amide
-
skin and lung enzyme
46.3
bovine prothrombin
-
-
-
0.03 - 8.9
Bz-Arg-p-nitroanilide
97 - 170
D-Ile-Pro-Arg-4-nitroanilide
3 - 40
D-Ile-Pro-Arg-p-nitroanilide
24.1 - 59.5
D-Phe-Pip-Arg-p-nitroanilide
2.8 - 5.3
D-Pro-Phe-Arg-p-nitroanilide
0.833 - 31
D-Val-Leu-Arg-p-nitroanilide
9 - 183
Glu-Gly-Arg-p-nitroanilide
1.5 - 56.9
Glu-Pro-Arg-p-nitroanilide
199
Ile-Arg-Asn-Lys-5-amino-2-nitrobenzoylamide
-
-
15.2 - 2630
MeOCO-Nle-Gly-Arg-p-nitroanilide
23.5
N-(p-tosyl)-Gly-Pro-Arg-4-nitroanilide
pH 8.0, 22°C
12
N-(p-tosyl)-Gly-Pro-Lys-p-nitroanilide
pH 8.0, 22°C
1.9 - 21
N-p-tosyl-Gly-Pro-Arg-p-nitroanilide
0.74 - 540
N-p-tosyl-Gly-Pro-Lys-p-nitroanilide
435
Pro-Ile-Arg-Asn-Lys-5-amino-2-nitrobenzoylamide
-
-
7
t-butyloxycarbonyl-Phe-Ser-Arg-4-methyl-coumarin 7-amide
-
pH 8.0, 30°C
0.5
Tert-Butyloxycarbonyl-Gly-Lys-Arg 4-methylcoumarin 7-amide
-
-
1.4
tert-butyloxycarbonyl-L-Val-L-Pro-L-Arg-4-methylcoumarin 7-amide
-
-
2.2
tert-butyloxycarbonyl-Phe-Ser-Arg 4-methylcoumarin 7-amide
-
-
27.9 - 75.5
tosyl-Gly-Pro-Lys-p-nitroanilide
1.9 - 10.3
Z-D-Arg-Gly-Arg-p-nitroanilide
additional information
additional information
-
1.1
Ac-PANK-AAC
-
pH 7.5, 30°C, betaI tryptase
3.5
Ac-PANK-AAC
-
pH 7.5, 30°C, betaII tryptase
0.97
Ac-PRNK-AAC
-
pH 7.5, 30°C, betaII tryptase
0.99
Ac-PRNK-AAC
-
pH 7.5, 30°C, betaI tryptase
3.8
Ac-PRNR-AAC
-
pH 7.5, 30°C, betaI tryptase
21.75
Ac-PRNR-AAC
-
pH 7.5, 30°C, betaII tryptase
21.8
Ac-PRNR-AAC
-
pH 7.5, 30°C, betaII tryptase
0.99
Ac-PRTK-AAC
-
pH 7.5, 30°C, betaI tryptase
1.1
Ac-PRTK-AAC
-
pH 7.5, 30°C, betaII tryptase
5.35
benzyloxycarbonyl-Arg 4-nitroanilide
-
skin enzyme
5.52
benzyloxycarbonyl-Arg 4-nitroanilide
-
lung enzyme
104
Benzyloxycarbonyl-Gly-Arg 4-trifluoromethylcoumarin 7-amide
-
skin enzyme
107
Benzyloxycarbonyl-Gly-Arg 4-trifluoromethylcoumarin 7-amide
-
lung enzyme
551
Benzyloxycarbonyl-Gly-Pro-Arg 4-nitroanilide
-
skin enzyme
553
Benzyloxycarbonyl-Gly-Pro-Arg 4-nitroanilide
-
lung enzyme
0.03 - 0.55
Bz-Arg-p-nitroanilide
-
pH 7.6, 20°C, isoform S2
1.66
Bz-Arg-p-nitroanilide
-
pH 7.6, 20°C, isoform L1
2.51
Bz-Arg-p-nitroanilide
-
pH 7.6, 20°C, isoform L2
2.94
Bz-Arg-p-nitroanilide
-
pH 7.6, 20°C, isoform L1
3 - 6
Bz-Arg-p-nitroanilide
-
pH 7.6, 20°C, isoform L2
6.51
Bz-Arg-p-nitroanilide
-
pH 7.6, 20°C, isoform S2
8.9
Bz-Arg-p-nitroanilide
-
pH 7.6, 20°C, isoform S1
97
D-Ile-Pro-Arg-4-nitroanilide
-
pH 6.8, 25°C, active enzyme tetramer, in presence of heparin and Na+
170
D-Ile-Pro-Arg-4-nitroanilide
-
pH 8.0, 25°C, active enzyme tetramer, in presence of heparin and Na+
3 - 6
D-Ile-Pro-Arg-p-nitroanilide
-
pH 6.0, 25°C, 200 ng protamine
5
D-Ile-Pro-Arg-p-nitroanilide
-
pH 6.0, 25°C, 150 ng polybrene
8
D-Ile-Pro-Arg-p-nitroanilide
-
pH 6.0, 25°C, 100 ng polybrene
9.9
D-Ile-Pro-Arg-p-nitroanilide
-
pH 6.0, 25°C, 80 ng polybrene
14
D-Ile-Pro-Arg-p-nitroanilide
-
pH 6.0, 25°C
16
D-Ile-Pro-Arg-p-nitroanilide
-
pH 6.0, 25°C, 100 ng protamine
17
D-Ile-Pro-Arg-p-nitroanilide
-
pH 6.0, 25°C, 60 ng polybrene
26
D-Ile-Pro-Arg-p-nitroanilide
-
pH 6.0, 25°C, 800 ng protamine
40
D-Ile-Pro-Arg-p-nitroanilide
-
pH 6.0, 25°C, 400 ng protamine
24.1
D-Phe-Pip-Arg-p-nitroanilide
-
pH 7.6, 20°C, isoform L2
27.1
D-Phe-Pip-Arg-p-nitroanilide
-
pH 7.6, 20°C, isoform S2
51
D-Phe-Pip-Arg-p-nitroanilide
-
pH 7.6, 20°C, isoform L1
59.5
D-Phe-Pip-Arg-p-nitroanilide
-
pH 7.6, 20°C, isoform S1
2.8
D-Pro-Phe-Arg-p-nitroanilide
-
pH 7.6, 20°C, isoform L2
5
D-Pro-Phe-Arg-p-nitroanilide
-
pH 7.6, 20°C, isoform L1
5.2
D-Pro-Phe-Arg-p-nitroanilide
-
pH 7.6, 20°C, isoform S2
5.3
D-Pro-Phe-Arg-p-nitroanilide
-
pH 7.6, 20°C, isoform S1
0.833
D-Val-Leu-Arg-p-nitroanilide
-
pH 7.6, 20°C, isoform S2
7.1
D-Val-Leu-Arg-p-nitroanilide
-
pH 7.6, 20°C, isoform L2
16.3
D-Val-Leu-Arg-p-nitroanilide
-
pH 7.6, 20°C, isoform S2
21.1
D-Val-Leu-Arg-p-nitroanilide
-
pH 7.6, 20°C, isoform L1
31
D-Val-Leu-Arg-p-nitroanilide
-
pH 7.6, 20°C, isoform S1
9
Glu-Gly-Arg-p-nitroanilide
-
pH 7.6, 20°C, isoform L1
60.6
Glu-Gly-Arg-p-nitroanilide
-
pH 7.6, 20°C, isoform L1
183
Glu-Gly-Arg-p-nitroanilide
-
pH 7.6, 20°C, isoform S1
1.5
Glu-Pro-Arg-p-nitroanilide
-
pH 7.6, 20°C, isoform L1
1.7
Glu-Pro-Arg-p-nitroanilide
-
pH 7.6, 20°C, isoform S2
2.6
Glu-Pro-Arg-p-nitroanilide
-
pH 7.6, 20°C, isoform L2
56.4
Glu-Pro-Arg-p-nitroanilide
-
pH 7.6, 20°C, isoform L1
56.9
Glu-Pro-Arg-p-nitroanilide
-
pH 7.6, 20°C, isoform L2
15.2
MeOCO-Nle-Gly-Arg-p-nitroanilide
-
pH 7.6, 20°C, isoform L2
22.9
MeOCO-Nle-Gly-Arg-p-nitroanilide
-
pH 7.6, 20°C, isoform L1
30.5
MeOCO-Nle-Gly-Arg-p-nitroanilide
-
pH 7.6, 20°C, isoform S2
2628
MeOCO-Nle-Gly-Arg-p-nitroanilide
-
pH 7.6, 20°C, isoform S1
2630
MeOCO-Nle-Gly-Arg-p-nitroanilide
-
pH 7.6, 20°C, isoform S1
1.9
N-p-tosyl-Gly-Pro-Arg-p-nitroanilide
-
pH 7.4, 37°C, D215G mutant
21
N-p-tosyl-Gly-Pro-Arg-p-nitroanilide
-
pH 7.4, 37°C, tryptase beta/II
0.74
N-p-tosyl-Gly-Pro-Lys-p-nitroanilide
-
pH 6.0, 25°C, 1200 ng polybrene
1.5
N-p-tosyl-Gly-Pro-Lys-p-nitroanilide
-
pH 6.0, 25°C, 1000 ng polybrene
2.6
N-p-tosyl-Gly-Pro-Lys-p-nitroanilide
-
pH 6.0, 25°C, 800 ng polybrene
3.6
N-p-tosyl-Gly-Pro-Lys-p-nitroanilide
-
pH 6.0, 25°C, 600 ng polybrene
3.9
N-p-tosyl-Gly-Pro-Lys-p-nitroanilide
-
pH 6.0, 25°C, 0.002 mg protamine
4.3
N-p-tosyl-Gly-Pro-Lys-p-nitroanilide
-
pH 6.0, 25°C
5.1
N-p-tosyl-Gly-Pro-Lys-p-nitroanilide
-
pH 6.0, 25°C, 0.0015 mg protamine
5.8
N-p-tosyl-Gly-Pro-Lys-p-nitroanilide
-
pH 6.0, 25°C, 0.001 mg protamine
6.08
N-p-tosyl-Gly-Pro-Lys-p-nitroanilide
-
pH 6.0, 25°C, 1200 ng polybrene
490
N-p-tosyl-Gly-Pro-Lys-p-nitroanilide
-
pH 8.2, 22°C, recombinant tryptase
540
N-p-tosyl-Gly-Pro-Lys-p-nitroanilide
-
pH 8.2, 22°C, HMC-1 tryptase
5.8
S-2288
mutant enzyme I99C/Y75A/Y37bA, at pH 6.8 and 25°C
6.7
S-2288
mutant enzyme I99C*/Y75A/Y37bA, at pH 6.8 and 25°C
37
S-2288
mutant enzyme Y75C, at pH 6.8 and 25°C
50
S-2288
mutant enzyme I99C, at pH 6.8 and 25°C
87
S-2288
wild type enzyme, at pH 6.8 and 25°C
27.9
tosyl-Gly-Pro-Lys-p-nitroanilide
-
pH 7.6, 20°C, isoform L2
40
tosyl-Gly-Pro-Lys-p-nitroanilide
-
pH 7.6, 20°C, isoform L1
45.9
tosyl-Gly-Pro-Lys-p-nitroanilide
-
pH 7.6, 20°C, isoform S2
75.5
tosyl-Gly-Pro-Lys-p-nitroanilide
-
pH 7.6, 20°C, isoform S1
1.9
Z-D-Arg-Gly-Arg-p-nitroanilide
-
pH 7.6, 20°C, isoform L1
3
Z-D-Arg-Gly-Arg-p-nitroanilide
-
pH 7.6, 20°C, isoform L2
5.4
Z-D-Arg-Gly-Arg-p-nitroanilide
-
pH 7.6, 20°C, isoform S2
10.3
Z-D-Arg-Gly-Arg-p-nitroanilide
-
pH 7.6, 20°C, isoform S1
additional information
additional information
-
overview: kinetic constant for the hydrolysis of synthetic thioester substrates and 4-nitroanilide substrates by the lung and by the skin enzyme
-
additional information
additional information
-
effect of NaCl on turnover number
-
additional information
additional information
-
of peptide 4-nitroanilide substrates
-
additional information
additional information
-
of peptide 4-nitroanilide substrates
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.00017
(Arg-Trp-Lys-Gly)4(Lys)2Lys-NH2
-
22°C, pH not specified in the publication
0.000323 - 0.00063
(Lys-Lys-Phe-Gly)4(Lys)2Lys-NH2
0.000006
1-acetyl-N-[(1S)-1-([5-[4-(2,3-dihydro-1H-inden-2-ylcarbamoyl)benzyl]-1,2,4-oxadiazol-3-yl]carbonyl)-3-pyrrolidin-3-ylpropyl]prolinamide
-
-
0.000005
1-methylethyl [5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]carbamate
-
-
0.000005
2-methoxyethyl [5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]carbamate
-
-
0.000018
3-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]-1,1-diethylurea
-
-
0.0000096
3-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]-1,1-dimethylurea
-
-
0.001
4-amino-N-[(9S,12R,16R)-16-(4-aminobutyl)-12-[(2S)-butan-2-yl]-9-(4-hydroxybenzyl)-2,6,11,14,18-pentaoxo-1,5,10,13,17-pentaazabicyclo[17.2.1]docos-7-en-3-yl]butanamide
-
-
0.05697
4-aminobenzamidine
-
22°C, pH not specified in the publication
0.000012
5-amino-N-[(9S,12R,16R)-16-(4-aminobutyl)-12-[(2S)-butan-2-yl]-9-(4-hydroxybenzyl)-2,6,11,14,18-pentaoxo-1,5,10,13,17-pentaazabicyclo[17.2.1]docos-7-en-3-yl]pentanamide
-
-
0.0000000953
6-amidino-2-naphthyl p-guanidinobenzoate dimethane sulfonate
-
pH 7.8, 37°C
0.000007
6-amino-N-[(9S,12R,16R)-12-[(2S)-butan-2-yl]-16-(3-carbamimidamidopropyl)-9-(4-hydroxybenzyl)-2,6,11,14,18-pentaoxo-1,5,10,13,17-pentaazabicyclo[17.2.1]docos-7-en-3-yl]hexanamide
-
-
0.000016
6-amino-N-[(9S,12R,16R)-16-(4-aminobutyl)-12-[(2S)-butan-2-yl]-9-(4-hydroxybenzyl)-2,6,11,14,18-pentaoxo-1,5,10,13,17-pentaazabicyclo[17.2.1]docos-7-en-3-yl]hexanamide
-
-
0.000023
7-amino-N-[(9S,12R,16R)-16-(4-aminobutyl)-12-[(2S)-butan-2-yl]-9-(4-hydroxybenzyl)-2,6,11,14,18-pentaoxo-1,5,10,13,17-pentaazabicyclo[17.2.1]docos-7-en-3-yl]heptanamide
-
-
0.000003
acetyl [(1S)-5-amino-1-([5-[4-(2,3-dihydro-1H-inden-2-ylcarbamoyl)benzyl]-1,2,4-oxadiazol-3-yl]carbonyl)pentyl]carbamate
-
-
0.3058
Arg-Trp-Lys-Gly-NH2
-
22°C, pH not specified in the publication
0.00047
benzyl 4-[(3-[N2-[(benzyloxy)carbonyl]-L-lysyl]-1,2,4-oxadiazol-5-yl)methyl]piperazine-1-carboxylate
-
-
0.012
benzyl [(1S)-2-(1,3-benzothiazol-2-yl)-1-(1H-indol-2-ylmethyl)-2-oxoethyl]carbamate
-
-
0.045
benzyl [(1S)-2-(1,3-benzothiazol-2-yl)-2-oxo-1-(1H-pyrrolo[2,3-c]pyridin-2-ylmethyl)ethyl]carbamate
-
-
0.0073
benzyl [(1S)-5-amino-1-(1,3-benzothiazol-2-ylcarbonyl)pentyl]carbamate
-
-
0.0000037
benzyl [(1S)-5-amino-1-([5-[4-(2,3-dihydro-1H-inden-2-ylcarbamoyl)benzyl]-1,2,4-oxadiazol-3-yl]carbonyl)pentyl]carbamate
-
-
0.000037
benzyl [(1S)-5-amino-1-([5-[4-(benzylcarbamoyl)benzyl]-1,2,4-oxadiazol-3-yl]carbonyl)pentyl]carbamate
-
-
0.000012
benzyl [(1S)-5-amino-1-([5-[4-(benzyloxy)benzyl]-1,2,4-oxadiazol-3-yl]carbonyl)pentyl]carbamate
-
-
0.0000082
benzyl [(1S)-5-amino-1-([5-[4-([2-[3-(trifluoromethyl)phenyl]ethyl]carbamoyl)benzyl]-1,2,4-oxadiazol-3-yl]carbonyl)pentyl]carbamate
-
-
0.00022
benzyl [(1S)-5-amino-1-([5-[4-([2-[4-(trifluoromethyl)phenyl]ethyl]carbamoyl)benzyl]-1,2,4-oxadiazol-3-yl]carbonyl)pentyl]carbamate
-
-
0.0000024
benzyl [(1S)-5-amino-1-[(5-[4-[(2-thiophen-2-ylethyl)carbamoyl]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]carbamate
-
-
0.000039
benzyl [(1S)-5-amino-1-[(5-[4-[(3,4-dimethylbenzyl)carbamoyl]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]carbamate
-
-
0.0000099
benzyl [(1S)-5-amino-1-[(5-[4-[(3-methylbutyl)carbamoyl]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]carbamate
-
-
0.000003 - 0.0000032
benzyl [(1S)-5-amino-1-[(5-[4-[(3-phenylpropyl)carbamoyl]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]carbamate
0.00006
benzyl [(1S)-5-amino-1-[(5-[4-[(4-phenylbutyl)carbamoyl]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]carbamate
-
-
0.000013
benzyl [(1S)-5-amino-1-[(5-[4-[(naphthalen-1-ylmethyl)carbamoyl]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]carbamate
-
-
0.000011
benzyl [(1S)-5-amino-1-[(5-[4-[(naphthalen-2-ylmethyl)carbamoyl]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]carbamate
-
-
0.00023
benzyl [(1S)-5-amino-1-[(5-[[4-(3-phenylpropanoyl)piperazin-1-yl]methyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]carbamate
-
-
0.000011
benzyl [(1S)-5-amino-1-[(5-[[4-(3-phenylpropyl)piperazin-1-yl]methyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]carbamate
-
-
0.000034
benzyl [(1S)-5-amino-1-[(5-[[4-(4-phenylbutanoyl)piperazin-1-yl]methyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]carbamate
-
-
0.0000058
benzyl [(1S)-5-amino-1-[(5-[[4-(4-phenylbutyl)piperazin-1-yl]methyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]carbamate
-
-
0.00077
benzyl [(1S)-5-amino-1-[[5-(4-methoxybenzyl)-1,2,4-oxadiazol-3-yl]carbonyl]pentyl]carbamate
-
-
0.0000036
benzyl [(1S)-5-amino-1-[[5-(4-[[(2E)-3-phenylprop-2-en-1-yl]carbamoyl]benzyl)-1,2,4-oxadiazol-3-yl]carbonyl]pentyl]carbamate
-
-
0.000016
benzyl [(1S)-5-amino-1-[[5-(4-[[2-(3,4-dichlorophenyl)ethyl]carbamoyl]benzyl)-1,2,4-oxadiazol-3-yl]carbonyl]pentyl]carbamate
-
-
0.0000035
benzyl [(1S)-5-amino-1-[[5-(4-[[2-(3,5-difluorophenyl)ethyl]carbamoyl]benzyl)-1,2,4-oxadiazol-3-yl]carbonyl]pentyl]carbamate
-
-
0.0000018
benzyl [(1S)-5-amino-1-[[5-(4-[[2-(3-chlorophenyl)ethyl]carbamoyl]benzyl)-1,2,4-oxadiazol-3-yl]carbonyl]pentyl]carbamate
-
-
0.0000029
benzyl [(1S)-5-amino-1-[[5-(4-[[2-(4-fluorophenoxy)ethyl]carbamoyl]benzyl)-1,2,4-oxadiazol-3-yl]carbonyl]pentyl]carbamate
-
-
0.00014
benzyl [(1S)-5-amino-1-[[5-(4-[[4-(2-fluorobenzyl)piperazin-1-yl]carbonyl]benzyl)-1,2,4-oxadiazol-3-yl]carbonyl]pentyl]carbamate
-
-
0.025
benzyl [(1S,3E)-5-amino-1-(1,3-benzothiazol-2-ylcarbonyl)pent-3-en-1-yl]carbamate
-
-
0.000096
benzyl((1S)-5-amino-1-[(5-(4-[(2,4-dichlorobenzyl)oxy]benzyl)-1,2,4-oxadiazol-3-yl)carbonyl]pentyl)carbamate
-
-
0.00001
benzyl((1S)-5-amino-1-[(5-(4-[(3,4-dichlorobenzyl)oxy]benzyl)-1,2,4-oxadiazol-3-yl)carbonyl]pentyl)carbamate
-
-
0.000024
benzyl((1S)-5-amino-1-[(5-(4-[(3,4-dimethoxybenzyl)oxy]benzyl)-1,2,4-oxadiazol-3-yl)carbonyl]pentyl)carbamate
-
-
0.000013
benzyl((1S)-5-amino-1-[(5-(4-[(3-chlorobenzyl)oxy]benzyl)-1,2,4-oxadiazol-3-yl)carbonyl]pentyl)carbamate
-
-
0.000041
benzyl((1S)-5-amino-1-[(5-(4-[(3-methoxybenzyl)oxy]benzyl)-1,2,4-oxadiazol-3-yl)carbonyl]pentyl)carbamate
-
-
0.000014
benzyl((1S)-5-amino-1-[(5-(4-[(4-chlorobenzyl)oxy]benzyl)-1,2,4-oxadiazol-3-yl)carbonyl]pentyl)carbamate
-
-
0.000016
benzyl((1S)-5-amino-1-[(5-(4-[(4-fluorobenzyl)oxy]benzyl)-1,2,4-oxadiazol-3-yl)carbonyl]pentyl)carbamate
-
-
0.000019
benzyl((1S)-5-amino-1-[(5-(4-[(4-methoxybenzyl)oxy]benzyl)-1,2,4-oxadiazol-3-yl)carbonyl]pentyl)carbamate
-
-
0.0027
benzyl((1S)-5-amino-1-[(5-benzyl-1,2,4-oxadiazol-3-yl)carbonyl]pentyl)carbamate
-
-
0.00036
benzyl[(1S)-5-amino-1-((5-[3-(2-phenylethoxy)benzyl]-1,2,4-oxadiazol-3-yl)carbonyl)pentyl]carbamate
-
-
0.00012
benzyl[(1S)-5-amino-1-((5-[3-(3-phenylpropoxy)benzyl]-1,2,4-oxadiazol-3-yl)carbonyl)pentyl]carbamate
-
-
0.000012
benzyl[(1S)-5-amino-1-((5-[4-(2-phenylethoxy)benzyl]-1,2,4-oxadiazol-3-yl)carbonyl)pentyl]carbamate
-
-
0.000025
benzyl[(1S)-5-amino-1-((5-[4-(3-phenylpropoxy)benzyl]-1,2,4-oxadiazol-3-yl)carbonyl)pentyl]carbamate
-
-
0.00018
benzyl[(1S)-5-amino-1-((5-[4-(benzyloxy)benzyl]-1,2,4-oxadiazol-3-yl)carbonyl)pentyl]carbamate
-
-
0.0011
benzyl[(1S)-5-amino-1-((5-[4-(cyclohexylmethoxy)benzyl]-1,2,4-oxadiazol-3-yl)carbonyl)pentyl]carbamate
-
-
0.000078
benzyl[(1S)-5-amino-1-((5-[4-(naphthalen-1-ylmethoxy)benzyl]-1,2,4-oxadiazol-3-yl)carbonyl)pentyl]carbamate
-
-
0.000027
benzyl[(1S)-5-amino-1-((5-[4-(naphthalen-2-ylmethoxy)benzyl]-1,2,4-oxadiazol-3-yl)carbonyl)pentyl]carbamate
-
-
0.00000062
CRA-2059
-
pH 8.0, 25°C, tryptase-beta
0.04
c[-Pro-beta3hArg(3-H2N-CH2)-D-allo-Ile-vTyr-NH-CH2-CH(NHAc)-CO-]
-
pH not specified in the publication, temperature not specified in the publication
0.000007
c[-Pro-beta3hArg(3-H2N-CH2)-D-allo-Ile-vTyr-NH-CH2-CH(NHCO-(CH2)5-NH2)-CO-]
-
pH not specified in the publication, temperature not specified in the publication
0.000025
c[-Pro-beta3hPhe(3-H2N-CH2)-D-allo-Ile-vTyr-NH-CH2-CH(NHCO-(CH2)5-NH2)-CO-]
-
pH not specified in the publication, temperature not specified in the publication
0.38
c[-Pro-beta3Lys(3-H2N-CH2)-D-allo-Ile-vTyr-NH-CH2-CH(NHAc)-CO-]
-
pH not specified in the publication, temperature not specified in the publication
0.0000028
ethyl [(1S)-5-amino-1-([5-[4-(2,3-dihydro-1H-inden-2-ylcarbamoyl)benzyl]-1,2,4-oxadiazol-3-yl]carbonyl)pentyl]carbamate
-
-
0.0000019
ethyl [(1S)-5-amino-1-[[5-(4-[[2-(3-chlorophenyl)ethyl]carbamoyl]benzyl)-1,2,4-oxadiazol-3-yl]carbonyl]pentyl]carbamate
-
-
0.0000047
ethyl [5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]carbamate
-
-
0.0000054
ethyl[(1S)-5-amino-1-((5-[4-(2-phenylethoxy)benzyl]-1,2,4-oxadiazol-3-yl)carbonyl)pentyl]carbamate
-
-
0.0000951
gabexate mesilate
-
pH 7.8, 37°C
0.4717
Lys-Lys-Phe-Gly-NH2
-
22°C, pH not specified in the publication
0.000028
MCoEeTI[K10R]
-
-
-
0.0006
MCoTI-II, MCoTI-II-DELTA[DG]
-
-
-
0.002
MCoTI-II-DELTA[GSDGV]
-
Ki above 0.002 mM
-
0.003
MCoTI-II-DELTA[SDGGV]
-
Ki above 0.003 mM
-
0.000009
MCoTI-II-DELTA[SDGG]
-
-
-
0.00001
MCoTI-II-DELTA[SDGG][K10R]
-
-
-
0.05
MCoTI-II[K10A], MCoTI-II[K10F], MCoTI-II[K10Q]
-
IC50 above 0.05 mM
-
0.085
MCoTI-II[K10R]
-
-
-
0.05
MCoTI-II[K10V], MCoTI-II[K10V]-[I11P], MCoTI-II[PKI]-[AVP]
-
IC50 above 0.05 mM
-
0.000011
methyl 4'-[3-([(6-chloronaphthalen-2-yl)sulfonyl][2-[(2-hydroxyethyl)(methyl)amino]-2-oxoethyl]amino)-2-oxopiperidin-1-yl]-3'-fluorobiphenyl-2-sulfinate
-
-
0.00013
methyl [(1S)-1-([5-[4-(2,3-dihydro-1H-inden-2-ylcarbamoyl)benzyl]-1,2,4-oxadiazol-3-yl]carbonyl)-3-pyrrolidin-3-ylpropyl]carbamate
-
-
0.000017
methyl [5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]carbamate
-
-
0.00045
N-[(1S)-1-([5-[4-(2,3-dihydro-1H-inden-2-ylcarbamoyl)benzyl]-1,2,4-oxadiazol-3-yl]carbonyl)-3-piperidin-4-ylpropyl]-3,4-difluorobenzamide
-
-
0.000021
N-[(1S)-1-([5-[4-(2,3-dihydro-1H-inden-2-ylcarbamoyl)benzyl]-1,2,4-oxadiazol-3-yl]carbonyl)-3-pyrrolidin-3-ylpropyl]-3,4-difluorobenzamide
-
-
0.00059
N-[(1S)-3-azetidin-3-yl-1-([5-[4-(2,3-dihydro-1H-inden-2-ylcarbamoyl)benzyl]-1,2,4-oxadiazol-3-yl]carbonyl)propyl]-3,4-difluorobenzamide
-
-
0.000004
N-[(1S)-5-amino-1-([5-[4-(2,3-dihydro-1H-inden-2-ylcarbamoyl)benzyl]-1,2,4-oxadiazol-3-yl]carbonyl)pentyl]-3,4-difluorobenzamide
-
-
0.0000021
N-[(1S)-5-amino-1-[[5-(4-[[2-(3-chlorophenyl)ethyl]carbamoyl]benzyl)-1,2,4-oxadiazol-3-yl]carbonyl]pentyl]-1,3-benzodioxole-5-carboxamide
-
-
0.0000017
N-[(1S)-5-amino-1-[[5-(4-[[2-(3-chlorophenyl)ethyl]carbamoyl]benzyl)-1,2,4-oxadiazol-3-yl]carbonyl]pentyl]-3,4-difluorobenzamide
-
-
0.0000015
N-[(1S)-5-amino-1-[[5-(4-[[2-(3-chlorophenyl)ethyl]carbamoyl]benzyl)-1,2,4-oxadiazol-3-yl]carbonyl]pentyl]-3,5-difluorobenzamide
-
-
0.0000017
N-[(1S)-5-amino-1-[[5-(4-[[2-(3-chlorophenyl)ethyl]carbamoyl]benzyl)-1,2,4-oxadiazol-3-yl]carbonyl]pentyl]-3-fluorobenzamide
-
-
0.0000019
N-[(1S)-5-amino-1-[[5-(4-[[2-(3-chlorophenyl)ethyl]carbamoyl]benzyl)-1,2,4-oxadiazol-3-yl]carbonyl]pentyl]-4-chlorobenzamide
-
-
0.0000018
N-[(1S)-5-amino-1-[[5-(4-[[2-(3-chlorophenyl)ethyl]carbamoyl]benzyl)-1,2,4-oxadiazol-3-yl]carbonyl]pentyl]-4-fluorobenzamide
-
-
0.04
N-[(9S,12R,16R)-12-[(2S)-butan-2-yl]-16-(3-carbamimidamidopropyl)-9-(4-hydroxybenzyl)-2,6,11,14,18-pentaoxo-1,5,10,13,17-pentaazabicyclo[17.2.1]docos-7-en-3-yl]acetamide
-
-
0.38
N-[(9S,12R,16R)-16-(4-aminobutyl)-12-[(2S)-butan-2-yl]-9-(4-hydroxybenzyl)-2,6,11,14,18-pentaoxo-1,5,10,13,17-pentaazabicyclo[17.2.1]docos-7-en-3-yl]acetamide
-
-
0.000002
N-[2-(3-chlorophenyl)ethyl]-4-([3-[N2-(2,2-dimethylpropanoyl)-L-lysyl]-1,2,4-oxadiazol-5-yl]methyl)benzamide
-
-
0.00019
N-[3-[4-(aminomethyl)phenyl]propyl]-N'-(1,2,3,4-tetrahydroisoquinolin-7-ylsulfanyl)ethane-1,2-diamine
-
-
0.00013
N-[3-[4-(aminomethyl)phenyl]propyl]-N'-(1-benzothiophen-2-ylsulfanyl)ethane-1,2-diamine
-
-
0.00021
N-[3-[4-(aminomethyl)phenyl]propyl]-N'-(1-benzothiophen-5-ylsulfanyl)ethane-1,2-diamine
-
-
0.0002
N-[3-[4-(aminomethyl)phenyl]propyl]-N'-(2,3-dihydro-1H-inden-5-ylsulfanyl)ethane-1,2-diamine
-
-
0.000073
N-[3-[4-(aminomethyl)phenyl]propyl]-N'-(naphthalen-2-ylsulfanyl)ethane-1,2-diamine
-
-
0.00076
N-[3-[4-(aminomethyl)phenyl]propyl]-N'-(phenylsulfanyl)ethane-1,2-diamine
-
-
0.00027
N-[3-[4-(aminomethyl)phenyl]propyl]-N'-[(2-methyl-1,3-benzothiazol-6-yl)sulfanyl]ethane-1,2-diamine
-
-
0.0000029
N-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]-2,2,2-trifluoroacetamide
-
-
0.0000038
N-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]-2,2-dimethylpropanamide
-
-
0.0000033
N-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]-2,4-difluorobenzamide
-
-
0.000046
N-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]-2,5-dimethylfuran-3-carboxamide
-
-
0.0000062
N-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]-2-fluorobenzamide
-
-
0.0000037
N-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]-2-methoxyacetamide
-
-
0.0000068
N-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]-2-methylpropanamide
-
-
0.0000076
N-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]-3,4-difluorobenzamide
-
-
0.0000058
N-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]-3-fluorobenzamide
-
-
0.0000066
N-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]-4-chlorobenzamide
-
-
0.0000025
N-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]-4-fluorobenzamide
-
-
0.0000065
N-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]cyclopentanecarboxamide
-
-
0.0000046
N-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]cyclopropanecarboxamide
-
-
0.0000023
N-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]furan-2-carboxamide
-
-
0.0000098
N-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]hexanamide
-
-
0.0000057
N-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]morpholine-4-carboxamide
-
-
0.0000092
N-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]piperidine-1-carboxamide
-
-
0.000032
N-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]pyrrolidine-1-carboxamide
-
-
0.000022
N-[5-amino-1-[(5-[4-[2-(3,4-dichlorophenyl)ethoxy]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]tetrahydrofuran-3-carboxamide
-
-
0.0023 - 0.0028
Pentamidine
0.000025
prop-2-en-1-yl [(1S)-1-([5-[4-(2,3-dihydro-1H-inden-2-ylcarbamoyl)benzyl]-1,2,4-oxadiazol-3-yl]carbonyl)-3-pyrrolidin-3-ylpropyl]carbamate
-
-
0.0000012
rLDT1
-
pH 7.6, 25°C
-
0.000001
RWJ-56423
-
pH 7.4, 37°C
0.000323
(Lys-Lys-Phe-Gly)4(Lys)2Lys-NH2
-
22°C, pH not specified in the publication
0.00063
(Lys-Lys-Phe-Gly)4(Lys)2Lys-NH2
-
22°C, pH not specified in the publication
0.0092
APC-1167
-
pH 8.2, 22°C, recombinant tryptase
0.0097
APC-1167
-
pH 8.2, 22°C
0.00053
APC-366
-
pH 6.0, 25°C, 4 h incubation
0.0017
APC-366
-
pH 8.2, 22°C, recombinant tryptase
0.0028
APC-366
-
pH 8.2, 22°C
0.25
APC-366
-
pH 6.0, 25°C, 40 min incubation
0.25
Aprotinin
-
pH 8.2, 22°C
0.369
Aprotinin
-
pH 8.2, 22°C, recombinant tryptase
0.0025
BABIM
-
pH 8.2, 22°C, recombinant tryptase
0.0046
BABIM
-
pH 8.2, 22°C
0.000003
benzyl [(1S)-5-amino-1-[(5-[4-[(3-phenylpropyl)carbamoyl]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]carbamate
-
-
0.0000032
benzyl [(1S)-5-amino-1-[(5-[4-[(3-phenylpropyl)carbamoyl]benzyl]-1,2,4-oxadiazol-3-yl)carbonyl]pentyl]carbamate
-
-
0.0023
Pentamidine
-
pH 8.2, 22°C, recombinant tryptase
0.0028
Pentamidine
-
pH 8.2, 22°C
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