enzyme is applied in an efficient one-pot multienzyme fucosylation system for high-yield synthesis of human blood group H antigens containing beta1-3-linked galactosides and an important human milk oligosaccharide lacto-N-fucopentaose I in preparative and gram scales
FUT1 transcript is expressed in some of tumor cell lines. The FUT1 transcript has several forms generated by two distinct transcription start sites and alternative splicing. Two transcription initiation sites of the FUT1 have been identified in gastric cancer cells and in ovarian cancer cells. Only exon 1A is a transcription start site in one more gastric cancer cell line, two colonic cancer cell lines, and in K562 cells, whereas only exon 2A has been identified in HEL cells and in bone marrow cells
transcript level for beta-D-galactoside alpha-2-L-fucosyltransferase is 40- and 340fold increased in all adenocarcinomas and tumor cell lines, respectively, compared to normal colon mucosa where a low level of mRNA transcript is detected. A variable increase in mRNA transcript levels is observed in 50% of adenomatous polyps. There are no tumor-associated allelic variations found within the H beta-D-galactoside alpha-2-Lfucosyltransferase cDNA
FUT2 SNPs rs601338 and rs602662 are associated with the risks of respiratory and diarrheal illnesses, as well as vomiting and nocturnal cough, from birth to 24 months of age in infants. The risk of diarrheal infections is significantly higher among infants possessing the G allele as compared to those with the A alleles in FUT2 SNPs. Longer breastfeeding duration predicted a lower risk of diarrhea, independent of infant FUT2 genotype
2.4.1.344 type 2 galactoside alpha-(1,2)-fucosyltransferase
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