2.3.1.194: acetoacetyl-CoA synthase
This is an abbreviated version!
For detailed information about acetoacetyl-CoA synthase, go to the full flat file.
Word Map on EC 2.3.1.194
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2.3.1.194
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polyester
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mevalonate
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synthases
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synthesis
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polyhydroxyalkanoates
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biomass
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biotechnology
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feedstock
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medicine
- 2.3.1.194
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polyester
- mevalonate
- synthases
- synthesis
- polyhydroxyalkanoates
- biomass
- biotechnology
-
feedstock
- medicine
Reaction
Synonyms
AACS, Acetoacetyl-CoA synthase, Acetoacetyl-CoA synthetase, acetoacetyl-coenzyme A synthase, acetoacetyl-coenzyme A synthesizing enzyme, More, NphT7, nphT7SCL, thiolase superfamily acetoacetyl-CoA synthase
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Application on EC 2.3.1.194 - acetoacetyl-CoA synthase
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biotechnology
medicine
histological changes, decreased steroid hormone concentrations and decreased cholesterol supply are observed in nicotine-treated fetal adrenals. The expression of genes regulating ketone metabolic process decreases in nicotine-treated fetal adrenals. Acetoacetyl-CoA synthetase (AACS), the enzyme utilizing ketones for cholesterol supply, displays decreased expression and increased DNA methylation in the proximal promoter of AACS
synthesis
the enzyme represents a potential target to increase the flux through the mevalonate pathway
biotechnology
the enzyme represents a potential target to increase the flux through the mevalonate pathway
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nphT7 can be used to significantly increase the concentration of acetoacetyl-CoA in cells, eventually leading to the production of useful terpenoids and poly-3-hydroxybutyrate
synthesis
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usage of the enzyme for recombinant high-level production of poly(3-hydroxybutyrate), P(3HB), in Escherichia coli and Corynebacterium glutamicum. P(3HB) is the natural aliphatic polyester that can be processed into a wide variety of consumer products, including plastics, films and fibers