2.1.1.374: 2-heptyl-1-hydroxyquinolin-4(1H)-one methyltransferase

This is an abbreviated version!
For detailed information about 2-heptyl-1-hydroxyquinolin-4(1H)-one methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.374

2.1.1.374

tuberculosis

salicylate

methyltransferases

menaquinone

rifampicin

multi-drug

antimycobacterial

mycobactericidal

bactericidal

s-adenosyl-l-methionine-dependent

n-methylated

isoquinolones

heterocyclic

2-heptyl-4-hydroxyquinoline

n-oxide

unamenable

para-aminosalicylic

benzoquinone

ubiquinone

plumbagin

Reaction

Synonyms

HQNO O-methyltransferase, htm, MAB_2834c, rv0560c

ECTree

2 Transferases

2.1 Transferring one-carbon groups

2.1.1 Methyltransferases

2.1.1.374 2-heptyl-1-hydroxyquinolin-4(1H)-one methyltransferase

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Results	in table
5	AA Sequence
1	Expression
9	General Information
1	Inhibitors
4	kcat/KM [mM/s]
4	KM Value [mM]
5	Natural Substrates/ Products (Substrates)
5	Organism
1	PDB ID
3	pH Optimum
1	Protein Variants
1	Reaction
5	Reference
25	Substrates and Products (Substrate)
10	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
4	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 2.1.1.374 - 2-heptyl-1-hydroxyquinolin-4(1H)-one methyltransferase

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S-adenosyl-L-methionine:2-heptyl-1-hydroxyquinolin-4(1H)-one methyltransferase

The enzyme, found in mycobacteria, is a member of a family of heterocyclic toxin methyltransferases. It is involved in defense against several antimicrobial natural compounds and drugs. 4-Hydroxyquinolin-2(1H)-one, 2-heptylquinolin-4(1H)-one, 2-heptyl-3-hydroxyquinolin-4(1H)-one (the "Pseudomonas quinolone signal", PQS) and the flavonol quercetin are also O-methylated, albeit with lower activity [2]. The enzyme also N-methylates the bactericidal compound 3-methyl-1-oxo-2-[3-oxo-3-(pyrrolidin-1-yl)propyl]-1,5-dihydrobenzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile [1].