2.1.1.374: 2-heptyl-1-hydroxyquinolin-4(1H)-one methyltransferase

This is an abbreviated version!
For detailed information about 2-heptyl-1-hydroxyquinolin-4(1H)-one methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.374

2.1.1.374

tuberculosis

salicylate

methyltransferases

menaquinone

rifampicin

multi-drug

antimycobacterial

mycobactericidal

bactericidal

s-adenosyl-l-methionine-dependent

n-methylated

isoquinolones

heterocyclic

2-heptyl-4-hydroxyquinoline

n-oxide

unamenable

para-aminosalicylic

benzoquinone

ubiquinone

plumbagin

Reaction

Synonyms

HQNO O-methyltransferase, htm, MAB_2834c, rv0560c

ECTree

2 Transferases

2.1 Transferring one-carbon groups

2.1.1 Methyltransferases

2.1.1.374 2-heptyl-1-hydroxyquinolin-4(1H)-one methyltransferase

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Results	in table
5	AA Sequence
1	Expression
9	General Information
1	Inhibitors
4	kcat/KM [mM/s]
4	KM Value [mM]
5	Natural Substrates/ Products (Substrates)
5	Organism
1	PDB ID
3	pH Optimum
1	Protein Variants
1	Reaction
5	Reference
25	Substrates and Products (Substrate)
10	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
4	Turnover Number [1/s]

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Reference on EC 2.1.1.374 - 2-heptyl-1-hydroxyquinolin-4(1H)-one methyltransferase

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759185

Sartor, P.; Bock, J.; Hennecke, U.; Thierbach, S.; Fetzner, S.

Modification of the Pseudomonasxa0aeruginosa toxin 2-heptyl-1-hydroxyquinolin-4(1H)-one and other secondary metabolites by methyltransferases from mycobacteria

FEBS J.

288

2360-2376

2020

Mycobacteroides abscessus (B1MCE2), Mycobacterium tuberculosis (P9WKL5), Mycobacteroides abscessus ATCC 19977 (B1MCE2), Mycobacterium tuberculosis ATCC 25618 (P9WKL5)

33064871

760066

Warrier, T.; Kapilashrami, K.; Argyrou, A.; Ioerger, T.; Little, D.; Murphye, K.; Nandakumar, M.; Park, S.; Gold, B.; Mi, J.; Zhang, T.; Meiler, E.; Rees, M.; Somersan-Karakaya, S.; Francisco, E.; Martinez-Hoyos, M.; Burns-Huang, K.; Roberts, J.; Ling, Y.

N-Methylation of a bactericidal compound as a resistance mechanism in Mycobacterium tuberculosis

Proc. Natl. Acad. Sci. USA

113

E4523-E4530

2016

Mycobacterium tuberculosis

27432954