2.1.1.364: [histone H3]-lysine4 N-methyltransferase
This is an abbreviated version!
For detailed information about [histone H3]-lysine4 N-methyltransferase, go to the full flat file.
Word Map on EC 2.1.1.364
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2.1.1.364
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pkmts
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non-histone
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monomethylation
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adomet
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monomethyltransferase
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set-domain
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sinefungin
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h3k4me1
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adohcy
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trithorax
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cyproheptadine
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trimethyltransferase
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carbon-oxygen
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analysis
- 2.1.1.364
-
pkmts
-
non-histone
-
monomethylation
- adomet
-
monomethyltransferase
-
set-domain
- sinefungin
-
h3k4me1
-
adohcy
-
trithorax
- cyproheptadine
-
trimethyltransferase
-
carbon-oxygen
- analysis
Reaction
Synonyms
chromatin histone H3-lysine 4 methyltransferase, H3-K4 HMT, histone lysine methyltransferase, histone lysine methyltransferase SET7/9, HKMT, KIAA1717, KMT7, PKMT, protein lysine methyltransferase, SET-domain protein lysine methyltransferase, SET7, SET7/9, SET9, SetD7
ECTree
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Application
Application on EC 2.1.1.364 - [histone H3]-lysine4 N-methyltransferase
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analysis
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ab initio quantum mechanical/molecular mechanical molecular dynamics simulations with the umbrella sampling method to determine free energy profiles for histone lysine methylation catalyzed by SET7/9 and its corresponding uncatalyzed reaction in aqueous solution, activation free energy barrier for the methyl transfer reaction catalyzed by SET7/9 is 22.5 kcal/mol, which agrees with the experimental value of 20.9 kcal/mol very well, SET7/9 lowers the barrier for the methyl-transfer reaction step by 8.4 kcal/mol compared with the uncatalyzed reaction
analysis
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multiple ab initio quantum mechanical/molecular mechanical free energy calculations and molecular dynamics simulations for the investigation of the methyl-transfer reaction catalyzed by SET7/9
analysis
development of a simple reliable label-free MALDI-TOF MS-based assay for the detection and quantification of peptide methylation, using SET7/9 as a model enzyme. The use of expensive internal standard often required in mass spectrometry quantitative analysis is not necessary in this assay