Disease on EC 2.1.1.364 - [histone H3]-lysine4 N-methyltransferase
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Breast Neoplasms
Identification of Cyproheptadine as an Inhibitor of SET Domain Containing Lysine Methyltransferase 7/9 (Set7/9) That Regulates Estrogen-Dependent Transcription.
Breast Neoplasms
SET7/9 inhibits oncogenic activities through regulation of Gli-1 expression in breast cancer.
Breast Neoplasms
SET7/9 promotes multiple malignant processes in breast cancer development via RUNX2 activation and is negatively regulated by TRIM21.
Carcinogenesis
Identification of Cyproheptadine as an Inhibitor of SET Domain Containing Lysine Methyltransferase 7/9 (Set7/9) That Regulates Estrogen-Dependent Transcription.
Carcinogenesis
Opposite Effects of SET7/9 on Apoptosis of Human Acute Myeloid Leukemia Cells and Lung Cancer Cells.
Carcinogenesis
Reduced expression of SET7/9, a histone mono-methyltransferase, is associated with gastric cancer progression.
Carcinoma, Hepatocellular
SET7/9 promotes hepatocellular carcinoma progression through regulation of E2F1.
Diabetes Mellitus
Role of SET7/9 in the progression of ischemic renal injury in diabetic and non-diabetic rats.
Diabetes Mellitus, Type 1
Histone H2AK119 and H2BK120 Monoubiquitination Modulate SET7/9 and SUV39H1 in Type 1 Diabetes Induced Renal Fibrosis.
Diabetes Mellitus, Type 2
SET7/9 Enzyme Regulates Cytokine-induced Expression of Inducible Nitric-oxide Synthase through Methylation of Lysine 4 at Histone 3 in the Islet ? Cell.
Glioma
SET7/9 promotes H3K4me3 at lncRNA DRAIC promoter to modulate growth and metastasis of glioma.
Glomerulonephritis, IGA
Inhibition of SET Domain-Containing Lysine Methyltransferase 7/9 Ameliorates Renal Fibrosis.
Glomerulonephritis, Membranous
Inhibition of SET Domain-Containing Lysine Methyltransferase 7/9 Ameliorates Renal Fibrosis.
Infections
Trimethylation of histone H3 lysine 4 by Set1 in the lytic infection of human herpes simplex virus 1.
Insulinoma
Methyltransferase Set7/9 maintains transcription and euchromatin structure at islet-enriched genes.
Leukemia
SMYD2 lysine methyltransferase regulates leukemia cell growth and regeneration after genotoxic stress.
Leukemia, Myeloid, Acute
Opposite Effects of SET7/9 on Apoptosis of Human Acute Myeloid Leukemia Cells and Lung Cancer Cells.
Lung Neoplasms
Opposite Effects of SET7/9 on Apoptosis of Human Acute Myeloid Leukemia Cells and Lung Cancer Cells.
Metabolic Diseases
Set7/9, a methyltransferase, regulates the thermogenic program during brown adipocyte differentiation through the modulation of p53 acetylation.
Neoplasm Metastasis
SET7/9 promotes H3K4me3 at lncRNA DRAIC promoter to modulate growth and metastasis of glioma.
Neoplasms
Methylation of SUV39H1 by SET7/9 results in heterochromatin relaxation and genome instability.
Neoplasms
Opposite Effects of SET7/9 on Apoptosis of Human Acute Myeloid Leukemia Cells and Lung Cancer Cells.
Neoplasms
Reduced expression of SET7/9, a histone mono-methyltransferase, is associated with gastric cancer progression.
Neoplasms
SET7/9 promotes multiple malignant processes in breast cancer development via RUNX2 activation and is negatively regulated by TRIM21.
Neoplasms
Small-Molecule Inhibitors of the Protein Methyltransferase SET7/9 Identified in a High-Throughput Screen.
Obesity
Set7/9, a methyltransferase, regulates the thermogenic program during brown adipocyte differentiation through the modulation of p53 acetylation.
Peritoneal Fibrosis
Inhibition of the H3K4 methyltransferase SET7/9 ameliorates peritoneal fibrosis.
Renal Insufficiency, Chronic
Histone Lysine Methylation in TGF-?1 Mediated p21 Gene Expression in Rat Mesangial Cells.
Stomach Neoplasms
Reduced expression of SET7/9, a histone mono-methyltransferase, is associated with gastric cancer progression.
Triple Negative Breast Neoplasms
Histone H3K4 Methyltransferases as Targets for Drug-Resistant Cancers.
Ureteral Obstruction
Inhibition of SET Domain-Containing Lysine Methyltransferase 7/9 Ameliorates Renal Fibrosis.
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