2.1.1.246: [methyl-Co(III) methanol-specific corrinoid protein]:coenzyme M methyltransferase

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For detailed information about [methyl-Co(III) methanol-specific corrinoid protein]:coenzyme M methyltransferase, go to the full flat file.

Reaction

Synonyms

Co-methyl-5-hydroxybenzimidazolylcobamide:2-mercapto-ethanesulphonic acid methyltransferase, methanol-specific methyltransferase 2, methanol:cob(I)alamin methyltransferase, methanol:coenzyme M methyltransferase, methylcobalamin:coenzyme M methyltransferase, methylcobamide:coenzyme M methyltransferase, methylcobamide:CoM methyltransferase, methyltransferase 2, MT2, MT2-A, MT2-M, mtaA

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.246 [methyl-Co(III) methanol-specific corrinoid protein]:coenzyme M methyltransferase

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Results	in table
4	Activating Compound
47	AA Sequence
2	Application
1	CAS Registry Number
8	Cloned(Commentary)
4	Expression
13	General Information
3	Inhibitors
3	KM Value [mM]
9	Metals/Ions
3	Molecular Weight [Da]
11	Natural Substrates/ Products (Substrates)
30	Organism
3	Pathway
8	pH Optimum
6	Protein Variants
6	Purification (Commentary)
2	Reaction
14	Reference
7	Source Tissue
14	Specific Activity [micromol/min/mg]
17	Substrates and Products (Substrate)
4	Subunits
32	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]

Systematic Name

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Systematic Name on EC 2.1.1.246 - [methyl-Co(III) methanol-specific corrinoid protein]:coenzyme M methyltransferase

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SYSTEMATIC NAME

IUBMB Comments

methylated methanol-specific corrinoid protein:coenzyme M methyltransferase

The enzyme, which is involved in methanogenesis from methanol, catalyses the transfer of a methyl group from a corrinoid protein (see EC 2.1.1.90, methanol---corrinoid protein Co-methyltransferase), where it is bound to the cobalt cofactor, to CoM, forming the substrate for EC 2.8.4.1, coenzyme-B sulfoethylthiotransferase, the enzyme that catalyses the final step in methanogenesis. Free methylcob(I)alamin can substitute for the corrinoid protein in vitro [5].