2.1.1.229: tRNA (carboxymethyluridine34-5-O)-methyltransferase

This is an abbreviated version!
For detailed information about tRNA (carboxymethyluridine34-5-O)-methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.229

2.1.1.229

wobble

methyltransferases

5-methoxycarbonylmethyluridine

ribonucleotide

anticodon

gene-specific

trnagluuuc

translationally

medicine

Reaction

5-(2-methoxy-2-oxoethyl)uridine34 in tRNA

Synonyms

ABH8, ALKBH8, CmoA, MnmC, Trm9, Trm9-Trm112, Trm9p, TrmC, tRNA methyltransferase 9, YfcK, YML014w

ECTree

2 Transferases

2.1 Transferring one-carbon groups

2.1.1 Methyltransferases

2.1.1.229 tRNA (carboxymethyluridine34-5-O)-methyltransferase

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Results	in table
3	Activating Compound
929	AA Sequence
1	Application
8	Cloned(Commentary)
7	Cofactor
4	Crystallization (Commentary)
1	Expression
27	General Information
1	Metals/Ions
1	Molecular Weight [Da]
20	Natural Substrates/ Products (Substrates)
14	Organism
2	Pathway
2	pH Optimum
1	Protein Variants
8	Purification (Commentary)
5	Reaction
14	Reference
1	Source Tissue
27	Substrates and Products (Substrate)
8	Subunits
23	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]

Cofactor

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Cofactor on EC 2.1.1.229 - tRNA (carboxymethyluridine34-5-O)-methyltransferase

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FAD

2 entries

S-adenosyl-L-methionine

4 entries

S-adenosyl-S-carboxymethyl-L-homocysteine

Escherichia coli

P76290

i.e. [(3S)-3-amino-3-carboxypropyl]{[(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl}(carboxymethyl)sulfanium, the enzyme contains a cofactor, S-adenosyl-S-carboxymethyl-L-homocysteine (SCM-SAH), in which the donor methyl group is substituted by a carboxymethyl group. The carboxyl moiety forms a salt-bridge interaction with Arg199 that is conserved in a large group of CmoA-related proteins but is not conserved in other S-adenosyl-L-methionine-containing enzymes. The active site contains one molecule cofactor S-adenosyl-S-carboxymethyl-L-homocysteine per monomer, and not S-adenosyl-L-methionine

735357