1.16.98.B1: mitochondrial amidoxime reducing component

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For detailed information about mitochondrial amidoxime reducing component, go to the full flat file.

Word Map on EC 1.16.98.B1

1.16.98.B1

marc

molybdenum

n-reductive

n-hydroxylated

prodrugs

xanthine

sulfite

molybdenum-containing

n-oxygenated

molybdopterin

biobank

three-component

pnpla3

benzamidoxime

flavin-containing

Reaction

2 [Fe(II)-cytochrome b5] + 2 H+ +

= 2 [Fe(III)-cytochrome b5] +

Synonyms

B4114_1419, mARC1, mARC2, mitochondrial amidoxime reducing component 2, mitochondrial amidoxime-reducing component 1, Moco sulfurase C-terminal domain protein, MOSC domain-containing protein, MTARC1, MTARC2, YiiM

ECTree

1 Oxidoreductases

1.16 Oxidizing metal ions

1.16.98 With other, known, physiological acceptors

1.16.98.B1 mitochondrial amidoxime reducing component

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Results	in table
3	AA Sequence
3	Cloned(Commentary)
4	Cofactor
3	Crystallization (Commentary)
31	Disease/ Diagnostics
3	General Information
14	KM Value [mM]
3	Localization
4	Metals/Ions
3	Molecular Weight [Da]
1	Natural Substrates/ Products (Substrates)
10	Organism
1	Reaction
10	Reference
5	Source Tissue
21	Specific Activity [micromol/min/mg]
19	Substrates and Products (Substrate)
5	Subunits
13	Synonyms
1	Systematic Name

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Reference on EC 1.16.98.B1 - mitochondrial amidoxime reducing component

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760519

Kotthaus, J.; Wahl, B.; Havemeyer, A.; Kotthaus, J.; Schade, D.; Garbe-Sch�nberg, D.; Mendel, R.; Bittner, F.; Clement, B.

Reduction of N(omega)-hydroxy-L-arginine by the mitochondrial amidoxime reducing component (mARC)

Biochem. J.

433

383-391

2011

Homo sapiens (Q5VT66), Homo sapiens (Q969Z3), Homo sapiens

21029045

760877

Krompholz, N.; Krischkowski, C.; Reichmann, D.; Garbe-Sch�nberg, D.; Mendel, R.R.; Bittner, F.; Clement, B.; Havemeyer, A.

The mitochondrial amidoxime reducing component (mARC) is involved in detoxification of N-hydroxylated base analogues

Chem. Res. Toxicol.

2443-2450

2012

Homo sapiens (Q5VT66), Homo sapiens (Q969Z3)

22924387

761442

Wahl, B.; Reichmann, D.; Niks, D.; Krompholz, N.; Havemeyer, A.; Clement, B.; Messerschmidt, T.; Rothkegel, M.; Biester, H.; Hille, R.; Mendel, R.R.; Bittner, F.

Biochemical and spectroscopic characterization of the human mitochondrial amidoxime reducing components hmARC-1 and hmARC-2 suggests the existence of a new molybdenum enzyme family in eukaryotes

J. Biol. Chem.

285

37847-37859

2010

Homo sapiens (Q5VT66), Homo sapiens (Q969Z3), Homo sapiens

20861021

761666

Gruenewald, S.; Wahl, B.; Bittner, F.; Hungeling, H.; Kanzow, S.; Kotthaus, J.; Schwering, U.; Mendel, R.R.; Clement, B.

The fourth molybdenum containing enzyme mARC cloning and involvement in the activation of N-hydroxylated prodrugs

J. Med. Chem.

8173-8177

2008

Homo sapiens (Q5VT66)

19053771

762276

Kubitza, C.; Bittner, F.; Ginsel, C.; Havemeyer, A.; Clement, B.; Scheidig, A.J.

Crystal structure of human mARC1 reveals its exceptional position among eukaryotic molybdenum enzymes

Proc. Natl. Acad. Sci. USA

115

11958-11963

2018

Homo sapiens (Q5VT66)

30397129

762452

Namgung, B.; Kim, J.H.; Song, W.S.; Yoon, S.I.

Crystal structure of the hydroxylaminopurine resistance protein, YiiM, and its putative molybdenum cofactor-binding catalytic site

Sci. Rep.

3304

2018

Escherichia coli, Geobacillus stearothermophilus (A0A150NEL9)

29459651