1.16.3.4: cuproxidase

This is an abbreviated version!
For detailed information about cuproxidase, go to the full flat file.

Reaction

4 Cu+ + 4 H+ +

Synonyms

ceruloplasmin, copper efflux oxidase, Cu(I) oxidase, CueO, CuiD, cuprous oxidase, DA2_0547, fet3p, More, multicopper oxidase, multicopper oxidase CueO, YacK

ECTree

     1 Oxidoreductases

         1.16 Oxidizing metal ions

             1.16.3 With oxygen as acceptor

                1.16.3.4 cuproxidase

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Results	in table
1	Activating Compound
6	AA Sequence
9	Cloned(Commentary)
7	Crystallization (Commentary)
3	Expression
11	General Information
3	Inhibitors
6	kcat/KM [mM/s]
2	Ki Value [mM]
23	KM Value [mM]
5	Localization
10	Metals/Ions
2	Molecular Weight [Da]
6	Natural Substrates/ Products (Substrates)
28	Organism
5	pH Optimum
1	pH Range
41	Protein Variants
2	Purification (Commentary)
1	Reaction
28	Reference
2	Renatured (Commentary)
8	Specific Activity [micromol/min/mg]
34	Substrates and Products (Substrate)
1	Subunits
36	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
3	Temperature Stability [°C]
17	Turnover Number [1/s]

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RENATURED/Commentary

ORGANISM

UNIPROT

LITERATURE

incubation of apo-CueO with excess CuSO4 (10 equiv) in Mops buffer (pH 7) in the presence of GSH (1 mM) at 4 °C leads to incorporation of copper ions

Escherichia coli

P36649

763183

the isolated enzyme does not exhibit any enzymatic activity and lacks the blue colour typical of multicopper oxidase. Supplementation of purified CueO with CuSO4 activates the enzyme and renders it blue

Desulfovibrio sp. A2

G2H480

763449