Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

1.16.3.4: cuproxidase

This is an abbreviated version!
For detailed information about cuproxidase, go to the full flat file.

Word Map on EC 1.16.3.4

Reaction

4 Cu+ + 4 H+ +

O2
= 4 Cu2+ + 2 H2O

Synonyms

ceruloplasmin, copper efflux oxidase, Cu(I) oxidase, CueO, CuiD, cuprous oxidase, DA2_0547, fet3p, More, multicopper oxidase, multicopper oxidase CueO, YacK

ECTree

     1 Oxidoreductases
         1.16 Oxidizing metal ions
             1.16.3 With oxygen as acceptor
                1.16.3.4 cuproxidase

Reference

topprint

Reference on EC 1.16.3.4 - cuproxidase

Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Classen, T.; Pietruszka, J.; Schuback, S.M.
A new multicopper oxidase from Gram-positive bacterium Rhodococcus erythropolis with activity modulating methionine rich tail
Protein Expr. Purif.
89
97-108
2013
Rhodococcus erythropolis
Manually annotated by BRENDA team
Komori, H.; Kataoka, K.; Tanaka, S.; Matsuda, N.; Higuchi, Y.; Sakurai, T.
Exogenous acetate ion reaches the type II copper centre in CueO through the water-excretion channel and potentially affects the enzymatic activity
Acta Crystallogr. Sect. F
72
558-563
2016
Escherichia coli (P36649)
Manually annotated by BRENDA team
Grass, G.; Rensing, C.
CueO is a multi-copper oxidase that confers copper tolerance in Escherichia coli
Biochem. Biophys. Res. Commun.
286
902-908
2001
Escherichia coli (P36649)
Manually annotated by BRENDA team
Kajikawa, T.; Kataoka, K.; Sakurai, T.
Modifications on the hydrogen bond network by mutations of Escherichia coli copper efflux oxidase affect the process of proton transfer to dioxygen leading to alterations of enzymatic activities
Biochem. Biophys. Res. Commun.
422
152-156
2012
Escherichia coli (P36649), Escherichia coli
Manually annotated by BRENDA team
Kataoka, K.; Kogi, H.; Tsujimura, S.; Sakurai, T.
Modifications of laccase activities of copper efflux oxidase, CueO by synergistic mutations in the first and second coordination spheres of the type I copper center
Biochem. Biophys. Res. Commun.
431
393-397
2013
Escherichia coli (P36649), Escherichia coli
Manually annotated by BRENDA team
Kataoka, K.; Hirota, S.; Maeda, Y.; Kogi, H.; Shinohara, N.; Sekimoto, M.; Sakurai, T.
Enhancement of laccase activity through the construction and breakdown of a hydrogen bond at the type I copper center in Escherichia coli CueO and the deletion mutant Deltaalpha5-7 CueO
Biochemistry
50
558-565
2011
Escherichia coli (P36649), Escherichia coli
Manually annotated by BRENDA team
Clement, R.; Wang, X.; Biaso, F.; Ilbert, M.; Mazurenko, I.; Lojou, E.
Mutations in the coordination spheres of T1 Cu affect Cu2+-activation of the laccase from Thermus thermophilus
Biochimie
182
228-237
2021
Thermus thermophilus (Q72HW2), Thermus thermophilus
Manually annotated by BRENDA team
Roulling, F.; Godin, A.; Feller, G.
Function and versatile location of Met-rich inserts in blue oxidases involved in bacterial copper resistance
Biochimie
194
118-126
2022
Pseudoalteromonas haloplanktis, Pseudoalteromonas haloplanktis TAC125
Manually annotated by BRENDA team
Stoj, C.; Kosman, D.J.
Cuprous oxidase activity of yeast Fet3p and human ceruloplasmin implication for function
FEBS Lett.
554
422-426
2003
Homo sapiens (P00450), Homo sapiens, Saccharomyces cerevisiae (P38993), Saccharomyces cerevisiae, Saccharomyces cerevisiae ATCC 204508 (P38993)
Manually annotated by BRENDA team
Achard, M.E.; Tree, J.J.; Holden, J.A.; Simpfendorfer, K.R.; Wijburg, O.L.; Strugnell, R.A.; Schembri, M.A.; Sweet, M.J.; Jennings, M.P.; McEwan, A.G.
The multi-copper-ion oxidase CueO of Salmonella enterica serovar typhimurium is required for systemic virulence
Infect. Immun.
78
2312-2319
2010
Salmonella enterica subsp. enterica serovar Typhimurium (Q8ZRS2), Salmonella enterica subsp. enterica serovar Typhimurium, Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720 (Q8ZRS2)
Manually annotated by BRENDA team
Djoko, K.Y.; Chong, L.X.; Wedd, A.G.; Xiao, Z.
Reaction mechanisms of the multicopper oxidase CueO from Escherichia coli support its functional role as a cuprous oxidase
J. Am. Chem. Soc.
132
2005-2015
2010
Escherichia coli (P36649), Escherichia coli
Manually annotated by BRENDA team
Kim, C.; Lorenz, W.; Hoopes, J.; Dean, J.
Oxidation of phenolate siderophores by the multicopper oxidase encoded by the Escherichia coli yacK gene
J. Bacteriol.
183
4866-4875
2001
Escherichia coli (P36649)
Manually annotated by BRENDA team
Singh, S.K.; Grass, G.; Rensing, C.; Montfort, W.R.
Cuprous oxidase activity of CueO from Escherichia coli
J. Bacteriol.
186
7815-7817
2004
Escherichia coli (P36649), Escherichia coli
Manually annotated by BRENDA team
Outten, F.; Huffman, D.; Hale, J.; OHalloran, T.
The Independent cue and cus systems confer copper tolerance during aerobic and anaerobic growth in Escherichia coli
J. Biol. Chem.
276
30670-30677
2001
Escherichia coli (P36649)
Manually annotated by BRENDA team
Roberts, S.; Wildner, G.; Grass, G.; Weichsel, A.; Ambrus, A.; Rensing, C.; Montfort, W.
A labile regulatory copper ion lies near the T1 copper site in the multicopper oxidase CueO
J. Biol. Chem.
278
31958-31963
2003
Escherichia coli (P36649)
Manually annotated by BRENDA team
Singh, S.K.; Roberts, S.A.; McDevitt, S.F.; Weichsel, A.; Wildner, G.F.; Grass, G.B.; Rensing, C.; Montfort, W.R.
Crystal structures of multicopper oxidase CueO bound to copper(I) and silver(I) functional role of a methionine-rich sequence
J. Biol. Chem.
286
37849-3757
2011
Escherichia coli (P36649), Escherichia coli K12 (P36649)
Manually annotated by BRENDA team
Singh, S.K.; Roberts, S.A.; McDevitt, S.F.; Weichsel, A.; Wildner, G.F.; Grass, G.B.; Rensing, C.; Montfort, W.R.
Crystal structures of multicopper oxidase CueO bound to copper(I) and silver(I) functional role of a methionine-rich sequence
J. Biol. Chem.
286
37849-37857
2011
Escherichia coli (P36649)
Manually annotated by BRENDA team
Galli, I.; Musci, G.; Bonaccorsi Di Patti, M.
Sequential reconstitution of copper sites in the multicopper oxidase CueO
J. Biol. Inorg. Chem.
9
90-95
2004
Escherichia coli (P36649)
Manually annotated by BRENDA team
Kataoka, K.; Komori, H.; Ueki, Y.; Konno, Y.; Kamitaka, Y.; Kurose, S.; Tsujimura, S.; Higuchi, Y.; Kano, K.; Seo, D.; Sakurai, T.
Structure and function of the engineered multicopper oxidase CueO from Escherichia coli - deletion of the methionine-rich helical region covering the substrate-binding site
J. Mol. Biol.
373
141-152
2007
Escherichia coli (P36649), Escherichia coli
Manually annotated by BRENDA team
Cortes, L.; Wedd, A.G.; Xiao, Z.
The functional roles of the three copper sites associated with the methionine-rich insert in the multicopper oxidase CueO from E. coli
Metallomics
7
776-785
2015
Escherichia coli (P36649), Escherichia coli
Manually annotated by BRENDA team
Mancini, S.; Kumar, R.; Mishra, V.; Solioz, M.
Desulfovibrio DA2_CueO is a novel multicopper oxidase with cuprous, ferrous and phenol oxidase activity
Microbiology
163
1229-1236
2017
Desulfovibrio sp. A2 (G2H480)
Manually annotated by BRENDA team
Roberts, S.; Weichsel, A.; Grass, G.; Thakali, K.; Hazzard, J.; Tollin, G.; Rensing, C.; Montfort, W.
Crystal structure and electron transfer kinetics of CueO, a multicopper oxidase required for copper homeostasis in Escherichia coli
Proc. Natl. Acad. Sci. USA
99
2766-2771
2002
Escherichia coli (P36649)
Manually annotated by BRENDA team
Wang, H.; Liu, X.; Zhao, J.; Yue, Q.; Yan, Y.; Gao, Z.; Dong, Y.; Zhang, Z.; Fan, Y.; Tian, J.; Wu, N.; Gong, Y.
Crystal structures of multicopper oxidase CueO G304K mutant structural basis of the increased laccase activity
Sci. Rep.
8
14252
2018
Escherichia coli (P36649), Escherichia coli
Manually annotated by BRENDA team