1.14.19.58: tryptophan 5-halogenase
This is an abbreviated version!
For detailed information about tryptophan 5-halogenase, go to the full flat file.
Word Map on EC 1.14.19.58
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1.14.19.58
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halogenases
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flavin-dependent
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regioselective
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7-halogenase
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chlorinate
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indole
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synthesis
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albogriseolus
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biocatalysts
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brominate
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cl
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flavin
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pharmacology
- 1.14.19.58
- halogenases
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flavin-dependent
-
regioselective
-
7-halogenase
-
chlorinate
- indole
- synthesis
- albogriseolus
-
biocatalysts
-
brominate
- cl
- flavin
- pharmacology
Reaction
Synonyms
halogenase, mibH, pyrH, sttH, trp-5-halogenase
ECTree
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General Information
General Information on EC 1.14.19.58 - tryptophan 5-halogenase
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evolution
malfunction
physiological function
structure comparisons reveal subtle amino acid differences within the MibH substrate binding site generates a solvent exposed crevice presumably involved in determining the substrate specificity of this unusual peptide halogenase
evolution
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structure comparisons reveal subtle amino acid differences within the MibH substrate binding site generates a solvent exposed crevice presumably involved in determining the substrate specificity of this unusual peptide halogenase
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a gene disruption mutant in the tryptophan 5-halogenase gene no longer produces the pyrroindomycin B, but still produces pyrroindomycin A, the nonhalogenated derivative
malfunction
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a gene disruption mutant in the tryptophan 5-halogenase gene no longer produces the pyrroindomycin B, but still produces pyrroindomycin A, the nonhalogenated derivative
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the enzyme is involved in the biosynthesis of the antibiotic pyrroindomycin B that contains an indole ring chlorinated in the 5 position
physiological function
expression in Arabidopsis thaliana leads to the formation of 5-chlorotryptophan, 5-chloroindole-3-acetonitrile and 5-chloro-3-indole acetic acid
physiological function
MibH is an FADH2-dependent Trp halogenase, that is only active when Trp is embedded within its cognate peptide substrate deschloro NAI-107
physiological function
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the enzyme is involved in the biosynthesis of the antibiotic pyrroindomycin B that contains an indole ring chlorinated in the 5 position
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physiological function
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MibH is an FADH2-dependent Trp halogenase, that is only active when Trp is embedded within its cognate peptide substrate deschloro NAI-107
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